| Full name: protein phosphatase 1 regulatory inhibitor subunit 14B | Alias Symbol: SOM172|PNG|PHI-1 | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 26472 | HGNC ID: HGNC:9057 | Ensembl Gene: ENSG00000173457 | OMIM ID: 601140 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PPP1R14B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R14B | 26472 | 212680_x_at | 0.7854 | 0.0955 | |
| GSE20347 | PPP1R14B | 26472 | 212680_x_at | 0.2462 | 0.2661 | |
| GSE23400 | PPP1R14B | 26472 | 212680_x_at | 0.4973 | 0.0000 | |
| GSE26886 | PPP1R14B | 26472 | 212680_x_at | 0.7463 | 0.0027 | |
| GSE29001 | PPP1R14B | 26472 | 212680_x_at | -0.0145 | 0.9727 | |
| GSE38129 | PPP1R14B | 26472 | 212680_x_at | 0.4732 | 0.0177 | |
| GSE45670 | PPP1R14B | 26472 | 212680_x_at | 0.5363 | 0.0019 | |
| GSE53622 | PPP1R14B | 26472 | 14508 | 0.5241 | 0.0000 | |
| GSE53624 | PPP1R14B | 26472 | 14508 | 0.6541 | 0.0000 | |
| GSE63941 | PPP1R14B | 26472 | 212680_x_at | -0.0956 | 0.8945 | |
| GSE77861 | PPP1R14B | 26472 | 212680_x_at | 0.3347 | 0.1036 | |
| GSE97050 | PPP1R14B | 26472 | A_23_P365817 | 0.7842 | 0.2110 | |
| SRP007169 | PPP1R14B | 26472 | RNAseq | -0.6386 | 0.0407 | |
| SRP008496 | PPP1R14B | 26472 | RNAseq | -0.4375 | 0.0294 | |
| SRP064894 | PPP1R14B | 26472 | RNAseq | 0.4060 | 0.1319 | |
| SRP133303 | PPP1R14B | 26472 | RNAseq | 0.4861 | 0.0564 | |
| SRP159526 | PPP1R14B | 26472 | RNAseq | 0.0230 | 0.9389 | |
| SRP193095 | PPP1R14B | 26472 | RNAseq | 0.0476 | 0.7914 | |
| SRP219564 | PPP1R14B | 26472 | RNAseq | 0.5219 | 0.3329 | |
| TCGA | PPP1R14B | 26472 | RNAseq | 0.4354 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPP1R14B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R14B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R14B | 26472 | 6 | 5 | 19 | |
| GSE20123 | PPP1R14B | 26472 | 6 | 5 | 19 | |
| GSE43470 | PPP1R14B | 26472 | 1 | 3 | 39 | |
| GSE46452 | PPP1R14B | 26472 | 8 | 4 | 47 | |
| GSE47630 | PPP1R14B | 26472 | 4 | 6 | 30 | |
| GSE54993 | PPP1R14B | 26472 | 3 | 0 | 67 | |
| GSE54994 | PPP1R14B | 26472 | 5 | 5 | 43 | |
| GSE60625 | PPP1R14B | 26472 | 0 | 4 | 7 | |
| GSE74703 | PPP1R14B | 26472 | 1 | 1 | 34 | |
| GSE74704 | PPP1R14B | 26472 | 4 | 3 | 13 | |
| TCGA | PPP1R14B | 26472 | 20 | 9 | 67 |
Total number of gains: 58; Total number of losses: 45; Total Number of normals: 385.
Somatic mutations of PPP1R14B:
Generating mutation plots.
Highly correlated genes for PPP1R14B:
Showing top 20/985 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R14B | ETNK1 | 0.718847 | 3 | 0 | 3 |
| PPP1R14B | LY6K | 0.712624 | 3 | 0 | 3 |
| PPP1R14B | NUDT22 | 0.705633 | 5 | 0 | 5 |
| PPP1R14B | DKC1 | 0.697764 | 3 | 0 | 3 |
| PPP1R14B | TOMM40 | 0.696932 | 7 | 0 | 7 |
| PPP1R14B | ZNF114 | 0.686032 | 4 | 0 | 4 |
| PPP1R14B | XPO5 | 0.685694 | 7 | 0 | 7 |
| PPP1R14B | DNAH14 | 0.681084 | 3 | 0 | 3 |
| PPP1R14B | ESPN | 0.678659 | 3 | 0 | 3 |
| PPP1R14B | KRT17 | 0.674913 | 3 | 0 | 3 |
| PPP1R14B | TMEM223 | 0.672927 | 9 | 0 | 9 |
| PPP1R14B | NOB1 | 0.670549 | 3 | 0 | 3 |
| PPP1R14B | CNNM4 | 0.667007 | 4 | 0 | 3 |
| PPP1R14B | RTKN | 0.666328 | 7 | 0 | 7 |
| PPP1R14B | LRP8 | 0.657139 | 8 | 0 | 7 |
| PPP1R14B | AMMECR1 | 0.655447 | 5 | 0 | 5 |
| PPP1R14B | TOP1MT | 0.654474 | 7 | 0 | 6 |
| PPP1R14B | WDR66 | 0.654162 | 7 | 0 | 7 |
| PPP1R14B | CDH3 | 0.654044 | 8 | 0 | 7 |
| PPP1R14B | FJX1 | 0.652507 | 9 | 0 | 7 |
For details and further investigation, click here
