| Full name: WD repeat domain 74 | Alias Symbol: FLJ10439|Nsa1 | ||
| Type: protein-coding gene | Cytoband: 11q12.3 | ||
| Entrez ID: 54663 | HGNC ID: HGNC:25529 | Ensembl Gene: ENSG00000133316 | OMIM ID: 617947 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of WDR74:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WDR74 | 54663 | 218278_at | 0.5032 | 0.0359 | |
| GSE20347 | WDR74 | 54663 | 218278_at | 0.5055 | 0.0000 | |
| GSE23400 | WDR74 | 54663 | 221712_s_at | 0.7194 | 0.0000 | |
| GSE26886 | WDR74 | 54663 | 218278_at | 0.4372 | 0.0208 | |
| GSE29001 | WDR74 | 54663 | 218278_at | 0.3977 | 0.0715 | |
| GSE38129 | WDR74 | 54663 | 218278_at | 0.4478 | 0.0000 | |
| GSE45670 | WDR74 | 54663 | 218278_at | 0.3625 | 0.0053 | |
| GSE53622 | WDR74 | 54663 | 61137 | 0.6021 | 0.0000 | |
| GSE53624 | WDR74 | 54663 | 61137 | 0.8763 | 0.0000 | |
| GSE63941 | WDR74 | 54663 | 218278_at | 1.2184 | 0.0013 | |
| GSE77861 | WDR74 | 54663 | 218278_at | 0.1414 | 0.1138 | |
| GSE97050 | WDR74 | 54663 | A_23_P36157 | 0.6326 | 0.2017 | |
| SRP007169 | WDR74 | 54663 | RNAseq | -0.6128 | 0.1408 | |
| SRP008496 | WDR74 | 54663 | RNAseq | -0.4839 | 0.3953 | |
| SRP064894 | WDR74 | 54663 | RNAseq | 0.6062 | 0.0157 | |
| SRP133303 | WDR74 | 54663 | RNAseq | -0.4086 | 0.0319 | |
| SRP159526 | WDR74 | 54663 | RNAseq | 0.5716 | 0.0022 | |
| SRP193095 | WDR74 | 54663 | RNAseq | -1.0923 | 0.0004 | |
| SRP219564 | WDR74 | 54663 | RNAseq | 0.5943 | 0.1114 | |
| TCGA | WDR74 | 54663 | RNAseq | 0.2545 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by WDR74 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WDR74:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WDR74 | 54663 | 6 | 5 | 19 | |
| GSE20123 | WDR74 | 54663 | 6 | 5 | 19 | |
| GSE43470 | WDR74 | 54663 | 1 | 6 | 36 | |
| GSE46452 | WDR74 | 54663 | 8 | 4 | 47 | |
| GSE47630 | WDR74 | 54663 | 3 | 7 | 30 | |
| GSE54993 | WDR74 | 54663 | 3 | 0 | 67 | |
| GSE54994 | WDR74 | 54663 | 5 | 5 | 43 | |
| GSE60625 | WDR74 | 54663 | 0 | 3 | 8 | |
| GSE74703 | WDR74 | 54663 | 1 | 3 | 32 | |
| GSE74704 | WDR74 | 54663 | 4 | 3 | 13 | |
| TCGA | WDR74 | 54663 | 13 | 11 | 72 |
Total number of gains: 50; Total number of losses: 52; Total Number of normals: 386.
Somatic mutations of WDR74:
Generating mutation plots.
Highly correlated genes for WDR74:
Showing top 20/725 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WDR74 | CCDC86 | 0.744721 | 8 | 0 | 8 |
| WDR74 | SAC3D1 | 0.730654 | 10 | 0 | 9 |
| WDR74 | LRWD1 | 0.719975 | 3 | 0 | 3 |
| WDR74 | EME1 | 0.717556 | 4 | 0 | 4 |
| WDR74 | UBE2C | 0.715242 | 10 | 0 | 10 |
| WDR74 | FEN1 | 0.710468 | 9 | 0 | 7 |
| WDR74 | CKAP2L | 0.709895 | 6 | 0 | 6 |
| WDR74 | CDC20 | 0.708275 | 11 | 0 | 10 |
| WDR74 | BOP1 | 0.707349 | 4 | 0 | 3 |
| WDR74 | CDCA5 | 0.705627 | 8 | 0 | 7 |
| WDR74 | BRMS1 | 0.703841 | 11 | 0 | 10 |
| WDR74 | POLR1A | 0.702961 | 4 | 0 | 4 |
| WDR74 | RFT1 | 0.702741 | 4 | 0 | 4 |
| WDR74 | POC1A | 0.702438 | 5 | 0 | 5 |
| WDR74 | RASSF6 | 0.69985 | 3 | 0 | 3 |
| WDR74 | HAUS8 | 0.699603 | 7 | 0 | 6 |
| WDR74 | SCYL1 | 0.6988 | 4 | 0 | 3 |
| WDR74 | TMEM223 | 0.697339 | 7 | 0 | 6 |
| WDR74 | STIP1 | 0.693745 | 11 | 0 | 9 |
| WDR74 | ZNF598 | 0.693646 | 5 | 0 | 5 |
For details and further investigation, click here
