| Full name: DNA topoisomerase III beta | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q11.22 | ||
| Entrez ID: 8940 | HGNC ID: HGNC:11993 | Ensembl Gene: ENSG00000100038 | OMIM ID: 603582 |
| Drug and gene relationship at DGIdb | |||
TOP3B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway |
Expression of TOP3B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TOP3B | 8940 | 213660_s_at | 0.1750 | 0.5862 | |
| GSE20347 | TOP3B | 8940 | 213660_s_at | -0.0074 | 0.9309 | |
| GSE23400 | TOP3B | 8940 | 213660_s_at | 0.0268 | 0.4386 | |
| GSE26886 | TOP3B | 8940 | 213660_s_at | 0.0624 | 0.7026 | |
| GSE29001 | TOP3B | 8940 | 213660_s_at | 0.1843 | 0.3378 | |
| GSE38129 | TOP3B | 8940 | 213660_s_at | 0.1033 | 0.2909 | |
| GSE45670 | TOP3B | 8940 | 213660_s_at | 0.2126 | 0.1508 | |
| GSE63941 | TOP3B | 8940 | 213660_s_at | 0.6742 | 0.0143 | |
| GSE77861 | TOP3B | 8940 | 213660_s_at | 0.0734 | 0.5834 | |
| GSE97050 | TOP3B | 8940 | A_33_P3364051 | 0.3027 | 0.2269 | |
| SRP007169 | TOP3B | 8940 | RNAseq | 0.3719 | 0.3238 | |
| SRP008496 | TOP3B | 8940 | RNAseq | 0.2377 | 0.4574 | |
| SRP064894 | TOP3B | 8940 | RNAseq | 1.0007 | 0.0000 | |
| SRP133303 | TOP3B | 8940 | RNAseq | 0.2031 | 0.1599 | |
| SRP159526 | TOP3B | 8940 | RNAseq | 0.3580 | 0.3208 | |
| SRP193095 | TOP3B | 8940 | RNAseq | 0.6266 | 0.0000 | |
| SRP219564 | TOP3B | 8940 | RNAseq | 0.6672 | 0.0770 | |
| TCGA | TOP3B | 8940 | RNAseq | 0.0884 | 0.1152 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TOP3B expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TOP3B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TOP3B | 8940 | 5 | 7 | 18 | |
| GSE20123 | TOP3B | 8940 | 5 | 6 | 19 | |
| GSE43470 | TOP3B | 8940 | 3 | 7 | 33 | |
| GSE46452 | TOP3B | 8940 | 33 | 1 | 25 | |
| GSE47630 | TOP3B | 8940 | 8 | 5 | 27 | |
| GSE54993 | TOP3B | 8940 | 3 | 6 | 61 | |
| GSE54994 | TOP3B | 8940 | 11 | 7 | 35 | |
| GSE60625 | TOP3B | 8940 | 5 | 0 | 6 | |
| GSE74703 | TOP3B | 8940 | 3 | 5 | 28 | |
| GSE74704 | TOP3B | 8940 | 2 | 3 | 15 | |
| TCGA | TOP3B | 8940 | 27 | 16 | 53 |
Total number of gains: 105; Total number of losses: 63; Total Number of normals: 320.
Somatic mutations of TOP3B:
Generating mutation plots.
Highly correlated genes for TOP3B:
Showing top 20/256 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TOP3B | TUBB | 0.752285 | 3 | 0 | 3 |
| TOP3B | RFXANK | 0.747612 | 4 | 0 | 4 |
| TOP3B | NR2C2AP | 0.711675 | 4 | 0 | 4 |
| TOP3B | MTCH1 | 0.698001 | 4 | 0 | 4 |
| TOP3B | UBE2J2 | 0.677062 | 3 | 0 | 3 |
| TOP3B | DHX16 | 0.669236 | 4 | 0 | 4 |
| TOP3B | GTF3C5 | 0.668899 | 3 | 0 | 3 |
| TOP3B | CLCN5 | 0.656828 | 3 | 0 | 3 |
| TOP3B | YIPF3 | 0.656204 | 3 | 0 | 3 |
| TOP3B | U2AF1 | 0.654817 | 3 | 0 | 3 |
| TOP3B | SLC27A5 | 0.654788 | 4 | 0 | 3 |
| TOP3B | ERCC2 | 0.65441 | 4 | 0 | 4 |
| TOP3B | DDOST | 0.653511 | 4 | 0 | 4 |
| TOP3B | ABCD4 | 0.653469 | 3 | 0 | 3 |
| TOP3B | STARD3 | 0.648598 | 5 | 0 | 4 |
| TOP3B | ZNF687 | 0.647182 | 3 | 0 | 3 |
| TOP3B | ATP6V0B | 0.646042 | 4 | 0 | 4 |
| TOP3B | KLHDC3 | 0.644284 | 5 | 0 | 4 |
| TOP3B | PRM1 | 0.640179 | 3 | 0 | 3 |
| TOP3B | MST1 | 0.639999 | 3 | 0 | 3 |
For details and further investigation, click here
