TUBB

 

Full name: tubulin beta class I Alias Symbol: OK/SW-cl.56|MGC16435|M40|Tubb5
Type: protein-coding gene Cytoband: 6p21.33
Entrez ID: 203068 HGNC ID: HGNC:20778 Ensembl Gene: ENSG00000196230 OMIM ID: 191130
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

TUBB involved pathways:

KEGG pathway Description View
hsa05130Pathogenic Escherichia coli infection

 

Expression of TUBB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TUBB 203068 211714_x_at 0.7561 0.0280
GSE20347 TUBB 203068 211714_x_at 0.8342 0.0001
GSE23400 TUBB 203068 211714_x_at 0.9555 0.0000
GSE26886 TUBB 203068 211714_x_at -0.1185 0.6565
GSE29001 TUBB 203068 211714_x_at 0.6724 0.0470
GSE38129 TUBB 203068 211714_x_at 0.9330 0.0000
GSE45670 TUBB 203068 211714_x_at 0.5278 0.0054
GSE53622 TUBB 203068 1835 0.9897 0.0000
GSE53624 TUBB 203068 1835 0.9217 0.0000
GSE63941 TUBB 203068 211714_x_at 0.8140 0.0774
GSE77861 TUBB 203068 211714_x_at 0.5635 0.0509
GSE97050 TUBB 203068 A_23_P387057 0.9110 0.0631
SRP007169 TUBB 203068 RNAseq 0.8891 0.0009
SRP008496 TUBB 203068 RNAseq 0.8347 0.0001
SRP064894 TUBB 203068 RNAseq 1.1973 0.0000
SRP133303 TUBB 203068 RNAseq 0.8066 0.0000
SRP159526 TUBB 203068 RNAseq 0.9566 0.0123
SRP193095 TUBB 203068 RNAseq 0.7699 0.0000
SRP219564 TUBB 203068 RNAseq 0.6917 0.0685
TCGA TUBB 203068 RNAseq 0.2976 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by TUBB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TUBB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TUBB 203068 5 1 24
GSE20123 TUBB 203068 5 1 24
GSE43470 TUBB 203068 5 1 37
GSE46452 TUBB 203068 1 10 48
GSE47630 TUBB 203068 7 3 30
GSE54993 TUBB 203068 2 1 67
GSE54994 TUBB 203068 11 4 38
GSE60625 TUBB 203068 0 1 10
GSE74703 TUBB 203068 5 0 31
GSE74704 TUBB 203068 2 0 18
TCGA TUBB 203068 18 16 62

Total number of gains: 61; Total number of losses: 38; Total Number of normals: 389.  

 

Somatic mutations of TUBB:

 

Generating mutation plots.

 

Highly correlated genes for TUBB:

 

Showing top 20/1567 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TUBBRANBP10.77157811011
TUBBTPX20.75697412011
TUBBILF20.75626812011
TUBBTOP3B0.752285303
TUBBTUBA1B0.7506961009
TUBBCOLGALT10.749198909
TUBBMSH60.74916210010
TUBBDNMT10.74750911010
TUBBUBE2C0.74657711010
TUBBFSCN10.74281610010
TUBBSSRP10.741377909
TUBBHSP90AB10.73855813012
TUBBNCAPH0.736928807
TUBBPFDN20.736883909
TUBBRNASEH2A0.73684713011
TUBBCDC200.73680911010
TUBBCDCA30.73431510010
TUBBMYBL20.73351111011
TUBBC1orf1120.732743808
TUBBMCM70.73011311010

For details and further investigation, click here