| Full name: tubulin polyglutamylase complex subunit 2 | Alias Symbol: DKFZP586M1523|HsT3006 | ||
| Type: protein-coding gene | Cytoband: 18q12.2 | ||
| Entrez ID: 25941 | HGNC ID: HGNC:24561 | Ensembl Gene: ENSG00000134779 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of TPGS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TPGS2 | 25941 | 212055_at | -0.5494 | 0.3289 | |
| GSE20347 | TPGS2 | 25941 | 212055_at | -0.2411 | 0.3216 | |
| GSE23400 | TPGS2 | 25941 | 213617_s_at | 0.3328 | 0.0007 | |
| GSE26886 | TPGS2 | 25941 | 212055_at | -0.1848 | 0.4924 | |
| GSE29001 | TPGS2 | 25941 | 212055_at | -0.4303 | 0.1990 | |
| GSE38129 | TPGS2 | 25941 | 212055_at | 0.0476 | 0.8453 | |
| GSE45670 | TPGS2 | 25941 | 213617_s_at | 0.0430 | 0.8737 | |
| GSE53622 | TPGS2 | 25941 | 14345 | -0.1636 | 0.0541 | |
| GSE53624 | TPGS2 | 25941 | 14345 | -0.2262 | 0.0006 | |
| GSE63941 | TPGS2 | 25941 | 213617_s_at | 0.1056 | 0.8730 | |
| GSE77861 | TPGS2 | 25941 | 212055_at | -0.5639 | 0.0691 | |
| SRP007169 | TPGS2 | 25941 | RNAseq | -0.3656 | 0.3143 | |
| SRP008496 | TPGS2 | 25941 | RNAseq | -0.1503 | 0.5796 | |
| SRP064894 | TPGS2 | 25941 | RNAseq | 0.1326 | 0.3827 | |
| SRP133303 | TPGS2 | 25941 | RNAseq | 0.2338 | 0.2830 | |
| SRP159526 | TPGS2 | 25941 | RNAseq | 0.3730 | 0.3764 | |
| SRP193095 | TPGS2 | 25941 | RNAseq | 0.1568 | 0.2427 | |
| SRP219564 | TPGS2 | 25941 | RNAseq | -0.1709 | 0.6750 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TPGS2 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of TPGS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TPGS2 | 25941 | 2 | 5 | 23 | |
| GSE20123 | TPGS2 | 25941 | 2 | 5 | 23 | |
| GSE43470 | TPGS2 | 25941 | 0 | 3 | 40 | |
| GSE46452 | TPGS2 | 25941 | 1 | 25 | 33 | |
| GSE47630 | TPGS2 | 25941 | 5 | 20 | 15 | |
| GSE54993 | TPGS2 | 25941 | 8 | 1 | 61 | |
| GSE54994 | TPGS2 | 25941 | 1 | 16 | 36 | |
| GSE60625 | TPGS2 | 25941 | 0 | 4 | 7 | |
| GSE74703 | TPGS2 | 25941 | 0 | 3 | 33 | |
| GSE74704 | TPGS2 | 25941 | 1 | 4 | 15 | |
| TCGA | TPGS2 | 25941 | 13 | 42 | 41 |
Total number of gains: 33; Total number of losses: 128; Total Number of normals: 327.
Somatic mutations of TPGS2:
Generating mutation plots.
Highly correlated genes for TPGS2:
Showing top 20/76 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TPGS2 | ARF4 | 0.675856 | 3 | 0 | 3 |
| TPGS2 | APIP | 0.672238 | 4 | 0 | 4 |
| TPGS2 | PLGRKT | 0.645645 | 4 | 0 | 3 |
| TPGS2 | CLINT1 | 0.641917 | 3 | 0 | 3 |
| TPGS2 | EHF | 0.635171 | 3 | 0 | 3 |
| TPGS2 | AKTIP | 0.628883 | 3 | 0 | 3 |
| TPGS2 | TLR5 | 0.624909 | 3 | 0 | 3 |
| TPGS2 | FBXO3 | 0.624123 | 4 | 0 | 3 |
| TPGS2 | RRAGA | 0.612872 | 4 | 0 | 3 |
| TPGS2 | ARL6IP5 | 0.612137 | 3 | 0 | 3 |
| TPGS2 | MFSD6 | 0.60512 | 4 | 0 | 3 |
| TPGS2 | CCNG1 | 0.595857 | 5 | 0 | 4 |
| TPGS2 | NDUFS4 | 0.585116 | 4 | 0 | 3 |
| TPGS2 | CCNC | 0.580038 | 5 | 0 | 4 |
| TPGS2 | UFC1 | 0.579969 | 3 | 0 | 3 |
| TPGS2 | SH3BGRL | 0.578911 | 4 | 0 | 3 |
| TPGS2 | GLCE | 0.574717 | 4 | 0 | 3 |
| TPGS2 | ASF1A | 0.572907 | 4 | 0 | 4 |
| TPGS2 | TMEM256 | 0.571896 | 3 | 0 | 3 |
| TPGS2 | PPIP5K2 | 0.57106 | 5 | 0 | 4 |
For details and further investigation, click here
