| Full name: dehydrogenase/reductase 1 | Alias Symbol: FLJ25430|MGC20204|SDR19C1 | ||
| Type: protein-coding gene | Cytoband: 14q12 | ||
| Entrez ID: 115817 | HGNC ID: HGNC:16445 | Ensembl Gene: ENSG00000157379 | OMIM ID: 610410 |
| Drug and gene relationship at DGIdb | |||
Expression of DHRS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHRS1 | 115817 | 213279_at | -1.9283 | 0.0724 | |
| GSE20347 | DHRS1 | 115817 | 213279_at | -2.3578 | 0.0000 | |
| GSE23400 | DHRS1 | 115817 | 213279_at | -1.3487 | 0.0000 | |
| GSE26886 | DHRS1 | 115817 | 213279_at | -2.8524 | 0.0000 | |
| GSE29001 | DHRS1 | 115817 | 213279_at | -2.0650 | 0.0000 | |
| GSE38129 | DHRS1 | 115817 | 213279_at | -1.8076 | 0.0000 | |
| GSE45670 | DHRS1 | 115817 | 213279_at | -0.8891 | 0.0103 | |
| GSE53622 | DHRS1 | 115817 | 31021 | -1.8208 | 0.0000 | |
| GSE53624 | DHRS1 | 115817 | 5063 | -2.1986 | 0.0000 | |
| GSE63941 | DHRS1 | 115817 | 213279_at | 0.3041 | 0.7275 | |
| GSE77861 | DHRS1 | 115817 | 213279_at | -1.6365 | 0.0017 | |
| GSE97050 | DHRS1 | 115817 | A_23_P48747 | -0.2296 | 0.5930 | |
| SRP007169 | DHRS1 | 115817 | RNAseq | -3.2330 | 0.0000 | |
| SRP008496 | DHRS1 | 115817 | RNAseq | -3.3509 | 0.0000 | |
| SRP064894 | DHRS1 | 115817 | RNAseq | -1.4374 | 0.0000 | |
| SRP133303 | DHRS1 | 115817 | RNAseq | -1.9688 | 0.0000 | |
| SRP159526 | DHRS1 | 115817 | RNAseq | -2.0858 | 0.0000 | |
| SRP193095 | DHRS1 | 115817 | RNAseq | -1.8489 | 0.0000 | |
| SRP219564 | DHRS1 | 115817 | RNAseq | -1.7282 | 0.0035 | |
| TCGA | DHRS1 | 115817 | RNAseq | -0.0055 | 0.9588 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by DHRS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DHRS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHRS1 | 115817 | 8 | 3 | 19 | |
| GSE20123 | DHRS1 | 115817 | 8 | 3 | 19 | |
| GSE43470 | DHRS1 | 115817 | 8 | 2 | 33 | |
| GSE46452 | DHRS1 | 115817 | 16 | 2 | 41 | |
| GSE47630 | DHRS1 | 115817 | 11 | 10 | 19 | |
| GSE54993 | DHRS1 | 115817 | 3 | 11 | 56 | |
| GSE54994 | DHRS1 | 115817 | 18 | 5 | 30 | |
| GSE60625 | DHRS1 | 115817 | 0 | 2 | 9 | |
| GSE74703 | DHRS1 | 115817 | 7 | 2 | 27 | |
| GSE74704 | DHRS1 | 115817 | 3 | 2 | 15 | |
| TCGA | DHRS1 | 115817 | 27 | 12 | 57 |
Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.
Somatic mutations of DHRS1:
Generating mutation plots.
Highly correlated genes for DHRS1:
Showing top 20/1747 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHRS1 | UPK3B | 0.875485 | 3 | 0 | 3 |
| DHRS1 | CWH43 | 0.866295 | 10 | 0 | 10 |
| DHRS1 | ENDOU | 0.860013 | 11 | 0 | 11 |
| DHRS1 | SCNN1B | 0.85263 | 11 | 0 | 11 |
| DHRS1 | CXCR2 | 0.844443 | 10 | 0 | 10 |
| DHRS1 | VSIG10L | 0.842239 | 7 | 0 | 7 |
| DHRS1 | EVPL | 0.834355 | 12 | 0 | 12 |
| DHRS1 | TGM1 | 0.831663 | 12 | 0 | 12 |
| DHRS1 | RMND5B | 0.831403 | 10 | 0 | 10 |
| DHRS1 | GDPD3 | 0.830402 | 12 | 0 | 12 |
| DHRS1 | MGLL | 0.829695 | 10 | 0 | 10 |
| DHRS1 | IL18 | 0.828492 | 11 | 0 | 11 |
| DHRS1 | RAET1E | 0.824236 | 7 | 0 | 7 |
| DHRS1 | CLIC3 | 0.823041 | 10 | 0 | 10 |
| DHRS1 | PADI1 | 0.821671 | 8 | 0 | 8 |
| DHRS1 | CYSRT1 | 0.820868 | 7 | 0 | 7 |
| DHRS1 | ECM1 | 0.819465 | 12 | 0 | 11 |
| DHRS1 | ACPP | 0.818541 | 11 | 0 | 11 |
| DHRS1 | LRRFIP2 | 0.818163 | 10 | 0 | 10 |
| DHRS1 | C18orf25 | 0.816532 | 10 | 0 | 10 |
For details and further investigation, click here
