| Full name: desumoylating isopeptidase 1 | Alias Symbol: D15Wsu75e | ||
| Type: protein-coding gene | Cytoband: 22q13.2 | ||
| Entrez ID: 27351 | HGNC ID: HGNC:24577 | Ensembl Gene: ENSG00000100418 | OMIM ID: 614637 |
| Drug and gene relationship at DGIdb | |||
Expression of DESI1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DESI1 | 27351 | 212528_at | -0.1599 | 0.7526 | |
| GSE20347 | DESI1 | 27351 | 212527_at | -1.0140 | 0.0002 | |
| GSE23400 | DESI1 | 27351 | 212527_at | -0.4387 | 0.0000 | |
| GSE26886 | DESI1 | 27351 | 212528_at | -0.9963 | 0.0001 | |
| GSE29001 | DESI1 | 27351 | 212527_at | -1.1214 | 0.0004 | |
| GSE38129 | DESI1 | 27351 | 212527_at | -0.5527 | 0.0689 | |
| GSE45670 | DESI1 | 27351 | 212527_at | -0.0969 | 0.6894 | |
| GSE53622 | DESI1 | 27351 | 8650 | -0.4892 | 0.0000 | |
| GSE53624 | DESI1 | 27351 | 8650 | -0.6072 | 0.0000 | |
| GSE63941 | DESI1 | 27351 | 212527_at | 0.6675 | 0.2250 | |
| GSE77861 | DESI1 | 27351 | 212527_at | -0.3691 | 0.2765 | |
| SRP007169 | DESI1 | 27351 | RNAseq | -1.3382 | 0.0008 | |
| SRP008496 | DESI1 | 27351 | RNAseq | -1.1447 | 0.0000 | |
| SRP064894 | DESI1 | 27351 | RNAseq | -0.3677 | 0.0581 | |
| SRP133303 | DESI1 | 27351 | RNAseq | -0.2971 | 0.0293 | |
| SRP159526 | DESI1 | 27351 | RNAseq | -0.3942 | 0.1659 | |
| SRP193095 | DESI1 | 27351 | RNAseq | -0.3369 | 0.0035 | |
| SRP219564 | DESI1 | 27351 | RNAseq | -0.2092 | 0.6839 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by DESI1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of DESI1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DESI1 | 27351 | 6 | 5 | 19 | |
| GSE20123 | DESI1 | 27351 | 6 | 4 | 20 | |
| GSE43470 | DESI1 | 27351 | 5 | 6 | 32 | |
| GSE46452 | DESI1 | 27351 | 31 | 2 | 26 | |
| GSE47630 | DESI1 | 27351 | 9 | 4 | 27 | |
| GSE54993 | DESI1 | 27351 | 3 | 6 | 61 | |
| GSE54994 | DESI1 | 27351 | 11 | 8 | 34 | |
| GSE60625 | DESI1 | 27351 | 5 | 0 | 6 | |
| GSE74703 | DESI1 | 27351 | 5 | 4 | 27 | |
| GSE74704 | DESI1 | 27351 | 3 | 2 | 15 | |
| TCGA | DESI1 | 27351 | 26 | 14 | 56 |
Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.
Somatic mutations of DESI1:
Generating mutation plots.
Highly correlated genes for DESI1:
Showing top 20/1014 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DESI1 | TMEM79 | 0.713665 | 4 | 0 | 4 |
| DESI1 | RASAL2 | 0.711725 | 6 | 0 | 6 |
| DESI1 | S100A16 | 0.705818 | 4 | 0 | 4 |
| DESI1 | PRDX5 | 0.696868 | 4 | 0 | 4 |
| DESI1 | TMEM40 | 0.693161 | 8 | 0 | 8 |
| DESI1 | LYPD3 | 0.686726 | 8 | 0 | 8 |
| DESI1 | GRHL3 | 0.684773 | 4 | 0 | 4 |
| DESI1 | SERPINB1 | 0.683188 | 8 | 0 | 8 |
| DESI1 | BNIPL | 0.676719 | 4 | 0 | 4 |
| DESI1 | RAB25 | 0.67632 | 8 | 0 | 8 |
| DESI1 | CLTB | 0.675273 | 9 | 0 | 9 |
| DESI1 | SLC35C1 | 0.673021 | 9 | 0 | 8 |
| DESI1 | TOM1 | 0.672687 | 11 | 0 | 9 |
| DESI1 | TMOD3 | 0.672439 | 8 | 0 | 8 |
| DESI1 | PMM1 | 0.672072 | 10 | 0 | 9 |
| DESI1 | TXN | 0.67178 | 10 | 0 | 8 |
| DESI1 | PTK6 | 0.668846 | 8 | 0 | 8 |
| DESI1 | ASCC2 | 0.667781 | 11 | 0 | 10 |
| DESI1 | OSTF1 | 0.667672 | 9 | 0 | 8 |
| DESI1 | CYSRT1 | 0.663156 | 4 | 0 | 4 |
For details and further investigation, click here
