| Full name: tubulin tyrosine ligase like 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q24.3 | ||
| Entrez ID: 23093 | HGNC ID: HGNC:19963 | Ensembl Gene: ENSG00000119685 | OMIM ID: 612268 |
| Drug and gene relationship at DGIdb | |||
Expression of TTLL5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTLL5 | 23093 | 214672_at | 0.2106 | 0.5271 | |
| GSE20347 | TTLL5 | 23093 | 214672_at | 0.1704 | 0.1841 | |
| GSE23400 | TTLL5 | 23093 | 214672_at | 0.4282 | 0.0000 | |
| GSE26886 | TTLL5 | 23093 | 214672_at | 0.8111 | 0.0001 | |
| GSE29001 | TTLL5 | 23093 | 214672_at | 0.4649 | 0.0262 | |
| GSE38129 | TTLL5 | 23093 | 214672_at | 0.1866 | 0.1088 | |
| GSE45670 | TTLL5 | 23093 | 214672_at | 0.3193 | 0.0095 | |
| GSE53622 | TTLL5 | 23093 | 60566 | 0.3754 | 0.0000 | |
| GSE53624 | TTLL5 | 23093 | 60566 | 0.3037 | 0.0000 | |
| GSE63941 | TTLL5 | 23093 | 214672_at | 1.0159 | 0.0115 | |
| GSE77861 | TTLL5 | 23093 | 214672_at | 0.0655 | 0.8827 | |
| GSE97050 | TTLL5 | 23093 | A_24_P321752 | 0.2233 | 0.4954 | |
| SRP007169 | TTLL5 | 23093 | RNAseq | -0.0446 | 0.9035 | |
| SRP008496 | TTLL5 | 23093 | RNAseq | 0.0393 | 0.8699 | |
| SRP064894 | TTLL5 | 23093 | RNAseq | 0.4726 | 0.0053 | |
| SRP133303 | TTLL5 | 23093 | RNAseq | 0.4434 | 0.0010 | |
| SRP159526 | TTLL5 | 23093 | RNAseq | 0.1222 | 0.6636 | |
| SRP193095 | TTLL5 | 23093 | RNAseq | 0.3301 | 0.0004 | |
| SRP219564 | TTLL5 | 23093 | RNAseq | 0.0772 | 0.8177 | |
| TCGA | TTLL5 | 23093 | RNAseq | 0.1534 | 0.0029 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TTLL5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTLL5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTLL5 | 23093 | 8 | 3 | 19 | |
| GSE20123 | TTLL5 | 23093 | 8 | 3 | 19 | |
| GSE43470 | TTLL5 | 23093 | 8 | 3 | 32 | |
| GSE46452 | TTLL5 | 23093 | 16 | 3 | 40 | |
| GSE47630 | TTLL5 | 23093 | 11 | 8 | 21 | |
| GSE54993 | TTLL5 | 23093 | 3 | 8 | 59 | |
| GSE54994 | TTLL5 | 23093 | 19 | 4 | 30 | |
| GSE60625 | TTLL5 | 23093 | 0 | 2 | 9 | |
| GSE74703 | TTLL5 | 23093 | 7 | 3 | 26 | |
| GSE74704 | TTLL5 | 23093 | 3 | 3 | 14 | |
| TCGA | TTLL5 | 23093 | 32 | 16 | 48 |
Total number of gains: 115; Total number of losses: 56; Total Number of normals: 317.
Somatic mutations of TTLL5:
Generating mutation plots.
Highly correlated genes for TTLL5:
Showing top 20/404 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTLL5 | TDRD5 | 0.653767 | 3 | 0 | 3 |
| TTLL5 | PRR12 | 0.639558 | 3 | 0 | 3 |
| TTLL5 | ALKBH1 | 0.638171 | 9 | 0 | 8 |
| TTLL5 | UBN1 | 0.637061 | 3 | 0 | 3 |
| TTLL5 | TRMT10C | 0.629436 | 3 | 0 | 3 |
| TTLL5 | ISCA2 | 0.628504 | 8 | 0 | 5 |
| TTLL5 | STARD10 | 0.622353 | 3 | 0 | 3 |
| TTLL5 | SLC5A12 | 0.619094 | 4 | 0 | 3 |
| TTLL5 | SNW1 | 0.617194 | 11 | 0 | 9 |
| TTLL5 | IFT43 | 0.61657 | 6 | 0 | 5 |
| TTLL5 | KIZ | 0.610667 | 3 | 0 | 3 |
| TTLL5 | SLC39A9 | 0.608514 | 7 | 0 | 6 |
| TTLL5 | PSMG3 | 0.608229 | 5 | 0 | 4 |
| TTLL5 | NPW | 0.607115 | 4 | 0 | 3 |
| TTLL5 | COQ6 | 0.606723 | 4 | 0 | 3 |
| TTLL5 | LZIC | 0.606673 | 4 | 0 | 3 |
| TTLL5 | JAG2 | 0.606445 | 8 | 0 | 6 |
| TTLL5 | WDR53 | 0.602319 | 5 | 0 | 4 |
| TTLL5 | PPP2R5E | 0.601872 | 7 | 0 | 5 |
| TTLL5 | ELMSAN1 | 0.601708 | 5 | 0 | 4 |
For details and further investigation, click here
