| Full name: jagged canonical Notch ligand 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q32.33 | ||
| Entrez ID: 3714 | HGNC ID: HGNC:6189 | Ensembl Gene: ENSG00000184916 | OMIM ID: 602570 |
| Drug and gene relationship at DGIdb | |||
JAG2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of JAG2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | JAG2 | 3714 | 32137_at | 1.1251 | 0.2130 | |
| GSE20347 | JAG2 | 3714 | 32137_at | 1.0398 | 0.0000 | |
| GSE23400 | JAG2 | 3714 | 209784_s_at | 1.1039 | 0.0000 | |
| GSE26886 | JAG2 | 3714 | 32137_at | 1.1657 | 0.0001 | |
| GSE29001 | JAG2 | 3714 | 32137_at | 0.9711 | 0.0384 | |
| GSE38129 | JAG2 | 3714 | 32137_at | 1.0976 | 0.0000 | |
| GSE45670 | JAG2 | 3714 | 32137_at | 0.7776 | 0.0010 | |
| GSE53622 | JAG2 | 3714 | 76669 | 0.9280 | 0.0000 | |
| GSE53624 | JAG2 | 3714 | 76669 | 0.8153 | 0.0000 | |
| GSE63941 | JAG2 | 3714 | 32137_at | 2.6445 | 0.0002 | |
| GSE77861 | JAG2 | 3714 | 209784_s_at | 0.5874 | 0.1059 | |
| GSE97050 | JAG2 | 3714 | A_23_P106024 | 0.5230 | 0.2248 | |
| SRP007169 | JAG2 | 3714 | RNAseq | 1.3396 | 0.0048 | |
| SRP008496 | JAG2 | 3714 | RNAseq | 1.8657 | 0.0000 | |
| SRP064894 | JAG2 | 3714 | RNAseq | 0.8151 | 0.0004 | |
| SRP133303 | JAG2 | 3714 | RNAseq | 0.9816 | 0.0000 | |
| SRP159526 | JAG2 | 3714 | RNAseq | 1.3997 | 0.0088 | |
| SRP193095 | JAG2 | 3714 | RNAseq | 1.2041 | 0.0000 | |
| SRP219564 | JAG2 | 3714 | RNAseq | 0.6221 | 0.1042 | |
| TCGA | JAG2 | 3714 | RNAseq | 0.4958 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by JAG2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of JAG2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | JAG2 | 3714 | 11 | 3 | 16 | |
| GSE20123 | JAG2 | 3714 | 10 | 2 | 18 | |
| GSE43470 | JAG2 | 3714 | 6 | 3 | 34 | |
| GSE46452 | JAG2 | 3714 | 18 | 4 | 37 | |
| GSE47630 | JAG2 | 3714 | 11 | 8 | 21 | |
| GSE54993 | JAG2 | 3714 | 5 | 10 | 55 | |
| GSE54994 | JAG2 | 3714 | 21 | 4 | 28 | |
| GSE60625 | JAG2 | 3714 | 0 | 2 | 9 | |
| GSE74703 | JAG2 | 3714 | 5 | 3 | 28 | |
| GSE74704 | JAG2 | 3714 | 5 | 2 | 13 | |
| TCGA | JAG2 | 3714 | 32 | 17 | 47 |
Total number of gains: 124; Total number of losses: 58; Total Number of normals: 306.
Somatic mutations of JAG2:
Generating mutation plots.
Highly correlated genes for JAG2:
Showing top 20/1169 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| JAG2 | PLEKHH1 | 0.769228 | 3 | 0 | 3 |
| JAG2 | ZFP90 | 0.75118 | 3 | 0 | 3 |
| JAG2 | KLHDC3 | 0.743285 | 3 | 0 | 3 |
| JAG2 | EMC3-AS1 | 0.718406 | 3 | 0 | 3 |
| JAG2 | PRKCZ | 0.714958 | 3 | 0 | 3 |
| JAG2 | RLIM | 0.707996 | 3 | 0 | 3 |
| JAG2 | USP21 | 0.706857 | 4 | 0 | 4 |
| JAG2 | DUS3L | 0.706749 | 3 | 0 | 3 |
| JAG2 | CMTM4 | 0.704821 | 5 | 0 | 4 |
| JAG2 | RNMT | 0.704186 | 3 | 0 | 3 |
| JAG2 | OSR2 | 0.70161 | 5 | 0 | 5 |
| JAG2 | LRRC58 | 0.697654 | 3 | 0 | 3 |
| JAG2 | ITGB4 | 0.694174 | 13 | 0 | 12 |
| JAG2 | APOBEC3G | 0.688989 | 3 | 0 | 3 |
| JAG2 | SLC39A3 | 0.688166 | 4 | 0 | 4 |
| JAG2 | AGRN | 0.685868 | 13 | 0 | 12 |
| JAG2 | COL7A1 | 0.685081 | 11 | 0 | 10 |
| JAG2 | TRAP1 | 0.678869 | 4 | 0 | 3 |
| JAG2 | NAP1L1 | 0.674801 | 4 | 0 | 4 |
| JAG2 | OTULIN | 0.673365 | 3 | 0 | 3 |
For details and further investigation, click here
