| Full name: thioredoxin | Alias Symbol: TRX | ||
| Type: protein-coding gene | Cytoband: 9q31.3 | ||
| Entrez ID: 7295 | HGNC ID: HGNC:12435 | Ensembl Gene: ENSG00000136810 | OMIM ID: 187700 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TXN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TXN | 7295 | 208864_s_at | -1.0593 | 0.0155 | |
| GSE20347 | TXN | 7295 | 208864_s_at | -1.0140 | 0.0000 | |
| GSE23400 | TXN | 7295 | 208864_s_at | -0.5996 | 0.0000 | |
| GSE26886 | TXN | 7295 | 208864_s_at | -1.0598 | 0.0002 | |
| GSE29001 | TXN | 7295 | 208864_s_at | -1.0535 | 0.0004 | |
| GSE38129 | TXN | 7295 | 208864_s_at | -0.4028 | 0.1755 | |
| GSE45670 | TXN | 7295 | 208864_s_at | -0.3246 | 0.0623 | |
| GSE53622 | TXN | 7295 | 63319 | -0.9096 | 0.0000 | |
| GSE53624 | TXN | 7295 | 63319 | -0.9261 | 0.0000 | |
| GSE63941 | TXN | 7295 | 208864_s_at | -0.3046 | 0.4781 | |
| GSE77861 | TXN | 7295 | 208864_s_at | -0.4974 | 0.0216 | |
| GSE97050 | TXN | 7295 | A_23_P60248 | -0.6445 | 0.3456 | |
| SRP007169 | TXN | 7295 | RNAseq | -1.7116 | 0.0011 | |
| SRP008496 | TXN | 7295 | RNAseq | -1.6128 | 0.0001 | |
| SRP064894 | TXN | 7295 | RNAseq | -1.4260 | 0.0000 | |
| SRP133303 | TXN | 7295 | RNAseq | -1.5941 | 0.0000 | |
| SRP159526 | TXN | 7295 | RNAseq | -1.4630 | 0.0002 | |
| SRP193095 | TXN | 7295 | RNAseq | -1.9108 | 0.0000 | |
| SRP219564 | TXN | 7295 | RNAseq | -1.6626 | 0.0059 | |
| TCGA | TXN | 7295 | RNAseq | 0.2633 | 0.0017 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by TXN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TXN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TXN | 7295 | 5 | 10 | 15 | |
| GSE20123 | TXN | 7295 | 5 | 9 | 16 | |
| GSE43470 | TXN | 7295 | 4 | 3 | 36 | |
| GSE46452 | TXN | 7295 | 6 | 13 | 40 | |
| GSE47630 | TXN | 7295 | 3 | 16 | 21 | |
| GSE54993 | TXN | 7295 | 3 | 3 | 64 | |
| GSE54994 | TXN | 7295 | 9 | 10 | 34 | |
| GSE60625 | TXN | 7295 | 0 | 0 | 11 | |
| GSE74703 | TXN | 7295 | 4 | 3 | 29 | |
| GSE74704 | TXN | 7295 | 2 | 6 | 12 | |
| TCGA | TXN | 7295 | 25 | 22 | 49 |
Total number of gains: 66; Total number of losses: 95; Total Number of normals: 327.
Somatic mutations of TXN:
Generating mutation plots.
Highly correlated genes for TXN:
Showing top 20/1114 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TXN | CYSRT1 | 0.757563 | 6 | 0 | 6 |
| TXN | EPGN | 0.752735 | 3 | 0 | 3 |
| TXN | KRT78 | 0.751348 | 7 | 0 | 7 |
| TXN | SH3PXD2A-AS1 | 0.737816 | 4 | 0 | 4 |
| TXN | BNIPL | 0.735469 | 7 | 0 | 7 |
| TXN | CLIC3 | 0.733532 | 9 | 0 | 9 |
| TXN | FAM3D | 0.733434 | 7 | 0 | 7 |
| TXN | LYPD3 | 0.73289 | 11 | 0 | 11 |
| TXN | SERPINB1 | 0.732295 | 11 | 0 | 11 |
| TXN | SPNS2 | 0.729765 | 5 | 0 | 5 |
| TXN | ENDOU | 0.724645 | 11 | 0 | 11 |
| TXN | TMEM154 | 0.723737 | 7 | 0 | 7 |
| TXN | FAM95B1 | 0.723179 | 3 | 0 | 3 |
| TXN | ZNF185 | 0.721968 | 11 | 0 | 11 |
| TXN | CYP4F22 | 0.718661 | 3 | 0 | 3 |
| TXN | OSTF1 | 0.715887 | 12 | 0 | 12 |
| TXN | KRT83 | 0.715552 | 3 | 0 | 3 |
| TXN | TMOD3 | 0.714642 | 11 | 0 | 11 |
| TXN | NDOR1 | 0.714272 | 4 | 0 | 4 |
| TXN | HOPX | 0.711874 | 11 | 0 | 11 |
For details and further investigation, click here
