| Full name: thymidylate synthetase | Alias Symbol: Tsase|TMS|HsT422 | ||
| Type: protein-coding gene | Cytoband: 18p11.32 | ||
| Entrez ID: 7298 | HGNC ID: HGNC:12441 | Ensembl Gene: ENSG00000176890 | OMIM ID: 188350 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TYMS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TYMS | 7298 | 202589_at | 1.1285 | 0.1259 | |
| GSE20347 | TYMS | 7298 | 202589_at | 1.0768 | 0.0001 | |
| GSE23400 | TYMS | 7298 | 202589_at | 1.3389 | 0.0000 | |
| GSE26886 | TYMS | 7298 | 202589_at | 0.9374 | 0.0187 | |
| GSE29001 | TYMS | 7298 | 202589_at | 1.3311 | 0.0003 | |
| GSE38129 | TYMS | 7298 | 202589_at | 1.3813 | 0.0000 | |
| GSE45670 | TYMS | 7298 | 202589_at | 0.8779 | 0.0003 | |
| GSE53622 | TYMS | 7298 | 83607 | 1.0663 | 0.0000 | |
| GSE53624 | TYMS | 7298 | 83607 | 1.3556 | 0.0000 | |
| GSE63941 | TYMS | 7298 | 202589_at | 1.5122 | 0.0560 | |
| GSE77861 | TYMS | 7298 | 202589_at | 0.5884 | 0.1362 | |
| GSE97050 | TYMS | 7298 | A_23_P50096 | 0.8065 | 0.1596 | |
| SRP007169 | TYMS | 7298 | RNAseq | 2.2719 | 0.0001 | |
| SRP008496 | TYMS | 7298 | RNAseq | 1.5746 | 0.0010 | |
| SRP064894 | TYMS | 7298 | RNAseq | 1.4803 | 0.0000 | |
| SRP133303 | TYMS | 7298 | RNAseq | 1.3333 | 0.0000 | |
| SRP159526 | TYMS | 7298 | RNAseq | 1.4973 | 0.0040 | |
| SRP193095 | TYMS | 7298 | RNAseq | 0.9061 | 0.0000 | |
| SRP219564 | TYMS | 7298 | RNAseq | 1.1891 | 0.0011 | |
| TCGA | TYMS | 7298 | RNAseq | 0.8141 | 0.0000 |
Upregulated datasets: 12; Downregulated datasets: 0.
Survival by TYMS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TYMS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TYMS | 7298 | 6 | 3 | 21 | |
| GSE20123 | TYMS | 7298 | 6 | 3 | 21 | |
| GSE43470 | TYMS | 7298 | 2 | 4 | 37 | |
| GSE46452 | TYMS | 7298 | 4 | 20 | 35 | |
| GSE47630 | TYMS | 7298 | 7 | 18 | 15 | |
| GSE54993 | TYMS | 7298 | 6 | 3 | 61 | |
| GSE54994 | TYMS | 7298 | 11 | 8 | 34 | |
| GSE60625 | TYMS | 7298 | 0 | 4 | 7 | |
| GSE74703 | TYMS | 7298 | 2 | 2 | 32 | |
| GSE74704 | TYMS | 7298 | 4 | 2 | 14 | |
| TCGA | TYMS | 7298 | 35 | 18 | 43 |
Total number of gains: 83; Total number of losses: 85; Total Number of normals: 320.
Somatic mutations of TYMS:
Generating mutation plots.
Highly correlated genes for TYMS:
Showing top 20/1919 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TYMS | NDC80 | 0.818747 | 13 | 0 | 13 |
| TYMS | MMS22L | 0.806604 | 3 | 0 | 3 |
| TYMS | GPR153 | 0.777679 | 4 | 0 | 4 |
| TYMS | UCK2 | 0.774233 | 3 | 0 | 3 |
| TYMS | LRRC58 | 0.766098 | 3 | 0 | 3 |
| TYMS | CCNB2 | 0.763892 | 11 | 0 | 10 |
| TYMS | MTBP | 0.76294 | 5 | 0 | 5 |
| TYMS | EBNA1BP2 | 0.75563 | 3 | 0 | 3 |
| TYMS | ASPM | 0.754028 | 12 | 0 | 12 |
| TYMS | MCM6 | 0.751065 | 13 | 0 | 12 |
| TYMS | CEP55 | 0.750441 | 12 | 0 | 12 |
| TYMS | MAGOH | 0.749151 | 3 | 0 | 3 |
| TYMS | KIF2C | 0.749022 | 12 | 0 | 11 |
| TYMS | C1orf112 | 0.748588 | 9 | 0 | 9 |
| TYMS | UBE2C | 0.748002 | 12 | 0 | 12 |
| TYMS | RAB11FIP5 | 0.745782 | 3 | 0 | 3 |
| TYMS | HJURP | 0.744675 | 12 | 0 | 12 |
| TYMS | DKC1 | 0.740172 | 3 | 0 | 3 |
| TYMS | C18orf54 | 0.739891 | 4 | 0 | 4 |
| TYMS | CENPF | 0.738829 | 13 | 0 | 12 |
For details and further investigation, click here
