| Full name: ribonuclease H2 subunit A | Alias Symbol: RNASEHI|RNHIA|RNHL|AGS4 | ||
| Type: protein-coding gene | Cytoband: 19p13.13 | ||
| Entrez ID: 10535 | HGNC ID: HGNC:18518 | Ensembl Gene: ENSG00000104889 | OMIM ID: 606034 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RNASEH2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RNASEH2A | 10535 | 203022_at | 1.2323 | 0.0911 | |
| GSE20347 | RNASEH2A | 10535 | 203022_at | 1.0278 | 0.0000 | |
| GSE23400 | RNASEH2A | 10535 | 203022_at | 0.8664 | 0.0000 | |
| GSE26886 | RNASEH2A | 10535 | 203022_at | 0.6404 | 0.0018 | |
| GSE29001 | RNASEH2A | 10535 | 203022_at | 1.1456 | 0.0364 | |
| GSE38129 | RNASEH2A | 10535 | 203022_at | 1.4258 | 0.0000 | |
| GSE45670 | RNASEH2A | 10535 | 203022_at | 1.2359 | 0.0001 | |
| GSE53622 | RNASEH2A | 10535 | 47504 | 1.1380 | 0.0000 | |
| GSE53624 | RNASEH2A | 10535 | 47504 | 1.5640 | 0.0000 | |
| GSE63941 | RNASEH2A | 10535 | 203022_at | 2.6274 | 0.0000 | |
| GSE77861 | RNASEH2A | 10535 | 203022_at | 0.7876 | 0.0119 | |
| GSE97050 | RNASEH2A | 10535 | A_23_P164826 | 0.9434 | 0.1349 | |
| SRP007169 | RNASEH2A | 10535 | RNAseq | 1.6630 | 0.0000 | |
| SRP008496 | RNASEH2A | 10535 | RNAseq | 1.2689 | 0.0000 | |
| SRP064894 | RNASEH2A | 10535 | RNAseq | 2.2024 | 0.0000 | |
| SRP133303 | RNASEH2A | 10535 | RNAseq | 1.3269 | 0.0000 | |
| SRP159526 | RNASEH2A | 10535 | RNAseq | 1.3830 | 0.0003 | |
| SRP193095 | RNASEH2A | 10535 | RNAseq | 0.8650 | 0.0000 | |
| SRP219564 | RNASEH2A | 10535 | RNAseq | 1.9286 | 0.0000 | |
| TCGA | RNASEH2A | 10535 | RNAseq | 0.8323 | 0.0000 |
Upregulated datasets: 13; Downregulated datasets: 0.
Survival by RNASEH2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RNASEH2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RNASEH2A | 10535 | 4 | 2 | 24 | |
| GSE20123 | RNASEH2A | 10535 | 3 | 1 | 26 | |
| GSE43470 | RNASEH2A | 10535 | 2 | 6 | 35 | |
| GSE46452 | RNASEH2A | 10535 | 47 | 1 | 11 | |
| GSE47630 | RNASEH2A | 10535 | 4 | 7 | 29 | |
| GSE54993 | RNASEH2A | 10535 | 16 | 3 | 51 | |
| GSE54994 | RNASEH2A | 10535 | 6 | 13 | 34 | |
| GSE60625 | RNASEH2A | 10535 | 9 | 0 | 2 | |
| GSE74703 | RNASEH2A | 10535 | 2 | 4 | 30 | |
| GSE74704 | RNASEH2A | 10535 | 0 | 1 | 19 | |
| TCGA | RNASEH2A | 10535 | 16 | 13 | 67 |
Total number of gains: 109; Total number of losses: 51; Total Number of normals: 328.
Somatic mutations of RNASEH2A:
Generating mutation plots.
Highly correlated genes for RNASEH2A:
Showing top 20/1990 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RNASEH2A | SPC24 | 0.850915 | 7 | 0 | 7 |
| RNASEH2A | AURKB | 0.832852 | 13 | 0 | 13 |
| RNASEH2A | TPX2 | 0.82066 | 13 | 0 | 12 |
| RNASEH2A | MYBL2 | 0.818738 | 12 | 0 | 12 |
| RNASEH2A | UBE2C | 0.814363 | 13 | 0 | 13 |
| RNASEH2A | CDC45 | 0.808932 | 12 | 0 | 12 |
| RNASEH2A | KIF22 | 0.807804 | 12 | 0 | 12 |
| RNASEH2A | MCM7 | 0.799919 | 13 | 0 | 12 |
| RNASEH2A | CKS1B | 0.799303 | 13 | 0 | 12 |
| RNASEH2A | KNSTRN | 0.798994 | 7 | 0 | 7 |
| RNASEH2A | PLK1 | 0.793925 | 11 | 0 | 11 |
| RNASEH2A | UBE2T | 0.790152 | 9 | 0 | 8 |
| RNASEH2A | DNMT1 | 0.789706 | 13 | 0 | 12 |
| RNASEH2A | ASF1B | 0.787839 | 13 | 0 | 12 |
| RNASEH2A | BIRC5 | 0.78726 | 12 | 0 | 11 |
| RNASEH2A | CDT1 | 0.786375 | 12 | 0 | 11 |
| RNASEH2A | MCM2 | 0.782769 | 13 | 0 | 12 |
| RNASEH2A | NUDT1 | 0.78271 | 13 | 0 | 12 |
| RNASEH2A | CENPF | 0.78181 | 13 | 0 | 12 |
| RNASEH2A | EXO1 | 0.781742 | 13 | 0 | 12 |
For details and further investigation, click here
