| Full name: mucolipin 3 | Alias Symbol: TRPML3|FLJ11006|TRP-ML3 | ||
| Type: protein-coding gene | Cytoband: 1p22.3 | ||
| Entrez ID: 55283 | HGNC ID: HGNC:13358 | Ensembl Gene: ENSG00000055732 | OMIM ID: 607400 |
| Drug and gene relationship at DGIdb | |||
Expression of MCOLN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MCOLN3 | 55283 | 229797_at | 0.2771 | 0.7767 | |
| GSE20347 | MCOLN3 | 55283 | 220484_at | 0.4924 | 0.0065 | |
| GSE23400 | MCOLN3 | 55283 | 220484_at | 0.3038 | 0.0000 | |
| GSE26886 | MCOLN3 | 55283 | 229797_at | 2.4515 | 0.0001 | |
| GSE29001 | MCOLN3 | 55283 | 220484_at | 0.5743 | 0.0052 | |
| GSE38129 | MCOLN3 | 55283 | 220484_at | 0.6138 | 0.0003 | |
| GSE45670 | MCOLN3 | 55283 | 229797_at | 0.4202 | 0.4407 | |
| GSE53622 | MCOLN3 | 55283 | 26815 | 0.8186 | 0.0001 | |
| GSE53624 | MCOLN3 | 55283 | 48423 | 0.7026 | 0.0002 | |
| GSE63941 | MCOLN3 | 55283 | 229797_at | -0.7650 | 0.6081 | |
| GSE77861 | MCOLN3 | 55283 | 242308_at | 0.1161 | 0.4673 | |
| GSE97050 | MCOLN3 | 55283 | A_33_P3238335 | -0.1674 | 0.5432 | |
| SRP064894 | MCOLN3 | 55283 | RNAseq | 1.6279 | 0.0002 | |
| SRP133303 | MCOLN3 | 55283 | RNAseq | 0.7993 | 0.0000 | |
| SRP159526 | MCOLN3 | 55283 | RNAseq | 2.4066 | 0.0002 | |
| SRP193095 | MCOLN3 | 55283 | RNAseq | 0.9253 | 0.0000 | |
| SRP219564 | MCOLN3 | 55283 | RNAseq | 1.3612 | 0.0452 | |
| TCGA | MCOLN3 | 55283 | RNAseq | -0.1153 | 0.6986 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by MCOLN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MCOLN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MCOLN3 | 55283 | 0 | 8 | 22 | |
| GSE20123 | MCOLN3 | 55283 | 0 | 8 | 22 | |
| GSE43470 | MCOLN3 | 55283 | 2 | 2 | 39 | |
| GSE46452 | MCOLN3 | 55283 | 0 | 1 | 58 | |
| GSE47630 | MCOLN3 | 55283 | 8 | 5 | 27 | |
| GSE54993 | MCOLN3 | 55283 | 0 | 0 | 70 | |
| GSE54994 | MCOLN3 | 55283 | 6 | 3 | 44 | |
| GSE60625 | MCOLN3 | 55283 | 0 | 0 | 11 | |
| GSE74703 | MCOLN3 | 55283 | 1 | 2 | 33 | |
| GSE74704 | MCOLN3 | 55283 | 0 | 5 | 15 | |
| TCGA | MCOLN3 | 55283 | 7 | 23 | 66 |
Total number of gains: 24; Total number of losses: 57; Total Number of normals: 407.
Somatic mutations of MCOLN3:
Generating mutation plots.
Highly correlated genes for MCOLN3:
Showing top 20/462 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MCOLN3 | DGKH | 0.749766 | 3 | 0 | 3 |
| MCOLN3 | BBS1 | 0.747293 | 3 | 0 | 3 |
| MCOLN3 | LANCL2 | 0.740454 | 4 | 0 | 4 |
| MCOLN3 | VEGFB | 0.733532 | 3 | 0 | 3 |
| MCOLN3 | MAP3K13 | 0.730612 | 3 | 0 | 3 |
| MCOLN3 | UCP2 | 0.727496 | 3 | 0 | 3 |
| MCOLN3 | FAM168A | 0.725047 | 3 | 0 | 3 |
| MCOLN3 | ERVW-1 | 0.724603 | 4 | 0 | 4 |
| MCOLN3 | ISM2 | 0.716265 | 3 | 0 | 3 |
| MCOLN3 | ZHX2 | 0.716134 | 4 | 0 | 4 |
| MCOLN3 | PHIP | 0.716083 | 4 | 0 | 3 |
| MCOLN3 | STARD3NL | 0.706155 | 3 | 0 | 3 |
| MCOLN3 | TGFB1I1 | 0.703597 | 3 | 0 | 3 |
| MCOLN3 | SGTB | 0.703206 | 3 | 0 | 3 |
| MCOLN3 | KIAA1257 | 0.702176 | 3 | 0 | 3 |
| MCOLN3 | PRR3 | 0.701971 | 3 | 0 | 3 |
| MCOLN3 | NLK | 0.691963 | 3 | 0 | 3 |
| MCOLN3 | C6orf141 | 0.687944 | 3 | 0 | 3 |
| MCOLN3 | PTPN2 | 0.68717 | 4 | 0 | 4 |
| MCOLN3 | TRPC1 | 0.682626 | 4 | 0 | 3 |
For details and further investigation, click here
