| Full name: uncoupling protein 3 | Alias Symbol: SLC25A9 | ||
| Type: protein-coding gene | Cytoband: 11q13.4 | ||
| Entrez ID: 7352 | HGNC ID: HGNC:12519 | Ensembl Gene: ENSG00000175564 | OMIM ID: 602044 |
| Drug and gene relationship at DGIdb | |||
Expression of UCP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UCP3 | 7352 | 219827_at | 0.0572 | 0.8664 | |
| GSE20347 | UCP3 | 7352 | 219827_at | -0.1405 | 0.0321 | |
| GSE23400 | UCP3 | 7352 | 219827_at | -0.1213 | 0.0005 | |
| GSE26886 | UCP3 | 7352 | 219827_at | 0.1576 | 0.1457 | |
| GSE29001 | UCP3 | 7352 | 219827_at | -0.3364 | 0.0124 | |
| GSE38129 | UCP3 | 7352 | 219827_at | -0.2617 | 0.0071 | |
| GSE45670 | UCP3 | 7352 | 219827_at | -0.0424 | 0.7413 | |
| GSE53622 | UCP3 | 7352 | 6895 | -1.2312 | 0.0000 | |
| GSE53624 | UCP3 | 7352 | 6895 | -1.8649 | 0.0000 | |
| GSE63941 | UCP3 | 7352 | 219827_at | 0.2354 | 0.1033 | |
| GSE77861 | UCP3 | 7352 | 219827_at | -0.1249 | 0.4058 | |
| GSE97050 | UCP3 | 7352 | A_24_P292470 | -0.3522 | 0.2240 | |
| SRP064894 | UCP3 | 7352 | RNAseq | 0.9438 | 0.0022 | |
| SRP133303 | UCP3 | 7352 | RNAseq | -0.2809 | 0.4162 | |
| SRP159526 | UCP3 | 7352 | RNAseq | 0.1502 | 0.7549 | |
| SRP219564 | UCP3 | 7352 | RNAseq | -0.1795 | 0.7039 | |
| TCGA | UCP3 | 7352 | RNAseq | -0.1589 | 0.4967 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by UCP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UCP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UCP3 | 7352 | 5 | 9 | 16 | |
| GSE20123 | UCP3 | 7352 | 5 | 8 | 17 | |
| GSE43470 | UCP3 | 7352 | 6 | 4 | 33 | |
| GSE46452 | UCP3 | 7352 | 9 | 20 | 30 | |
| GSE47630 | UCP3 | 7352 | 6 | 14 | 20 | |
| GSE54993 | UCP3 | 7352 | 8 | 3 | 59 | |
| GSE54994 | UCP3 | 7352 | 8 | 15 | 30 | |
| GSE60625 | UCP3 | 7352 | 0 | 7 | 4 | |
| GSE74703 | UCP3 | 7352 | 5 | 3 | 28 | |
| GSE74704 | UCP3 | 7352 | 3 | 4 | 13 | |
| TCGA | UCP3 | 7352 | 26 | 28 | 42 |
Total number of gains: 81; Total number of losses: 115; Total Number of normals: 292.
Somatic mutations of UCP3:
Generating mutation plots.
Highly correlated genes for UCP3:
Showing top 20/779 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UCP3 | SPINK7 | 0.833878 | 3 | 0 | 3 |
| UCP3 | TEAD3 | 0.826676 | 3 | 0 | 3 |
| UCP3 | FAM163B | 0.823119 | 3 | 0 | 3 |
| UCP3 | KRTAP20-1 | 0.801929 | 3 | 0 | 3 |
| UCP3 | OR2Z1 | 0.796658 | 3 | 0 | 3 |
| UCP3 | OR5AS1 | 0.781607 | 3 | 0 | 3 |
| UCP3 | KPRP | 0.779829 | 3 | 0 | 3 |
| UCP3 | BARHL2 | 0.774035 | 3 | 0 | 3 |
| UCP3 | GPX6 | 0.764419 | 3 | 0 | 3 |
| UCP3 | MUC22 | 0.752937 | 3 | 0 | 3 |
| UCP3 | NCCRP1 | 0.750568 | 3 | 0 | 3 |
| UCP3 | OTOF | 0.747575 | 6 | 0 | 6 |
| UCP3 | MFSD2B | 0.741428 | 3 | 0 | 3 |
| UCP3 | OTOP3 | 0.723961 | 3 | 0 | 3 |
| UCP3 | BOK | 0.722776 | 4 | 0 | 4 |
| UCP3 | RNF222 | 0.721044 | 3 | 0 | 3 |
| UCP3 | TMPRSS11A | 0.720451 | 3 | 0 | 3 |
| UCP3 | MYZAP | 0.715365 | 3 | 0 | 3 |
| UCP3 | PGC | 0.701593 | 3 | 0 | 3 |
| UCP3 | PRSS27 | 0.697048 | 4 | 0 | 3 |
For details and further investigation, click here
