| Full name: UDP glycosyltransferase 8 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q26 | ||
| Entrez ID: 7368 | HGNC ID: HGNC:12555 | Ensembl Gene: ENSG00000174607 | OMIM ID: 601291 |
| Drug and gene relationship at DGIdb | |||
Expression of UGT8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UGT8 | 7368 | 228956_at | 0.2334 | 0.8929 | |
| GSE20347 | UGT8 | 7368 | 208358_s_at | 0.4511 | 0.0665 | |
| GSE23400 | UGT8 | 7368 | 208358_s_at | 0.1447 | 0.0026 | |
| GSE26886 | UGT8 | 7368 | 228956_at | 1.3583 | 0.0028 | |
| GSE29001 | UGT8 | 7368 | 208358_s_at | 0.5492 | 0.1080 | |
| GSE38129 | UGT8 | 7368 | 208358_s_at | 0.8697 | 0.0019 | |
| GSE45670 | UGT8 | 7368 | 228956_at | 0.7781 | 0.2912 | |
| GSE53622 | UGT8 | 7368 | 16671 | -0.2109 | 0.3610 | |
| GSE53624 | UGT8 | 7368 | 16671 | -0.8520 | 0.0000 | |
| GSE63941 | UGT8 | 7368 | 208358_s_at | 3.1645 | 0.0434 | |
| GSE77861 | UGT8 | 7368 | 208358_s_at | 0.8281 | 0.0743 | |
| GSE97050 | UGT8 | 7368 | A_24_P103264 | 0.9536 | 0.2827 | |
| SRP007169 | UGT8 | 7368 | RNAseq | 2.4771 | 0.0000 | |
| SRP064894 | UGT8 | 7368 | RNAseq | 0.8668 | 0.0576 | |
| SRP133303 | UGT8 | 7368 | RNAseq | 1.0503 | 0.0206 | |
| SRP159526 | UGT8 | 7368 | RNAseq | 2.2981 | 0.0000 | |
| SRP193095 | UGT8 | 7368 | RNAseq | -0.2771 | 0.2917 | |
| TCGA | UGT8 | 7368 | RNAseq | -0.1953 | 0.5823 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by UGT8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UGT8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UGT8 | 7368 | 1 | 13 | 16 | |
| GSE20123 | UGT8 | 7368 | 1 | 13 | 16 | |
| GSE43470 | UGT8 | 7368 | 0 | 14 | 29 | |
| GSE46452 | UGT8 | 7368 | 1 | 36 | 22 | |
| GSE47630 | UGT8 | 7368 | 0 | 22 | 18 | |
| GSE54993 | UGT8 | 7368 | 9 | 0 | 61 | |
| GSE54994 | UGT8 | 7368 | 1 | 10 | 42 | |
| GSE60625 | UGT8 | 7368 | 0 | 3 | 8 | |
| GSE74703 | UGT8 | 7368 | 0 | 12 | 24 | |
| GSE74704 | UGT8 | 7368 | 0 | 7 | 13 | |
| TCGA | UGT8 | 7368 | 8 | 35 | 53 |
Total number of gains: 21; Total number of losses: 165; Total Number of normals: 302.
Somatic mutations of UGT8:
Generating mutation plots.
Highly correlated genes for UGT8:
Showing top 20/253 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UGT8 | WTAP | 0.67842 | 3 | 0 | 3 |
| UGT8 | PLAC1 | 0.678102 | 3 | 0 | 3 |
| UGT8 | LARP6 | 0.65811 | 3 | 0 | 3 |
| UGT8 | FKBP4 | 0.656038 | 3 | 0 | 3 |
| UGT8 | TLCD1 | 0.646526 | 3 | 0 | 3 |
| UGT8 | FASTKD3 | 0.643748 | 3 | 0 | 3 |
| UGT8 | CCDC77 | 0.64116 | 4 | 0 | 3 |
| UGT8 | MDM4 | 0.639011 | 3 | 0 | 3 |
| UGT8 | MRPL50 | 0.637952 | 3 | 0 | 3 |
| UGT8 | LRIG3 | 0.636096 | 4 | 0 | 4 |
| UGT8 | NCR3LG1 | 0.633262 | 3 | 0 | 3 |
| UGT8 | CLCN2 | 0.632749 | 3 | 0 | 3 |
| UGT8 | ADSL | 0.630365 | 5 | 0 | 4 |
| UGT8 | LYPD6B | 0.629171 | 4 | 0 | 3 |
| UGT8 | MRPL36 | 0.628833 | 3 | 0 | 3 |
| UGT8 | POLA1 | 0.624068 | 3 | 0 | 3 |
| UGT8 | IMMP1L | 0.624012 | 3 | 0 | 3 |
| UGT8 | DSG2 | 0.623472 | 6 | 0 | 4 |
| UGT8 | PRKX | 0.622 | 5 | 0 | 4 |
| UGT8 | ZNF266 | 0.621344 | 3 | 0 | 3 |
For details and further investigation, click here
