| Full name: NPL4 homolog, ubiquitin recognition factor | Alias Symbol: NPL4|FLJ20657|KIAA1499 | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 55666 | HGNC ID: HGNC:18261 | Ensembl Gene: ENSG00000182446 | OMIM ID: 606590 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of NPLOC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPLOC4 | 55666 | 217796_s_at | 0.4652 | 0.1039 | |
| GSE20347 | NPLOC4 | 55666 | 217796_s_at | 0.1620 | 0.2292 | |
| GSE23400 | NPLOC4 | 55666 | 217796_s_at | 0.1917 | 0.0004 | |
| GSE26886 | NPLOC4 | 55666 | 217796_s_at | -0.3542 | 0.0198 | |
| GSE29001 | NPLOC4 | 55666 | 217796_s_at | 0.2393 | 0.3913 | |
| GSE38129 | NPLOC4 | 55666 | 217796_s_at | 0.2915 | 0.0024 | |
| GSE45670 | NPLOC4 | 55666 | 217796_s_at | 0.3991 | 0.0035 | |
| GSE53622 | NPLOC4 | 55666 | 79403 | 0.0325 | 0.6731 | |
| GSE53624 | NPLOC4 | 55666 | 79403 | 0.3670 | 0.0000 | |
| GSE63941 | NPLOC4 | 55666 | 217796_s_at | -0.0394 | 0.9115 | |
| GSE77861 | NPLOC4 | 55666 | 217796_s_at | 0.3016 | 0.0803 | |
| GSE97050 | NPLOC4 | 55666 | A_33_P3238966 | 0.1354 | 0.4976 | |
| SRP007169 | NPLOC4 | 55666 | RNAseq | -0.4258 | 0.1468 | |
| SRP008496 | NPLOC4 | 55666 | RNAseq | -0.3461 | 0.0283 | |
| SRP064894 | NPLOC4 | 55666 | RNAseq | 0.3393 | 0.0652 | |
| SRP133303 | NPLOC4 | 55666 | RNAseq | 0.3781 | 0.0157 | |
| SRP159526 | NPLOC4 | 55666 | RNAseq | 0.4140 | 0.1291 | |
| SRP193095 | NPLOC4 | 55666 | RNAseq | 0.2712 | 0.0044 | |
| SRP219564 | NPLOC4 | 55666 | RNAseq | -0.0832 | 0.7877 | |
| TCGA | NPLOC4 | 55666 | RNAseq | 0.0828 | 0.0486 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NPLOC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPLOC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPLOC4 | 55666 | 4 | 4 | 22 | |
| GSE20123 | NPLOC4 | 55666 | 4 | 4 | 22 | |
| GSE43470 | NPLOC4 | 55666 | 3 | 5 | 35 | |
| GSE46452 | NPLOC4 | 55666 | 34 | 0 | 25 | |
| GSE47630 | NPLOC4 | 55666 | 9 | 2 | 29 | |
| GSE54993 | NPLOC4 | 55666 | 2 | 5 | 63 | |
| GSE54994 | NPLOC4 | 55666 | 10 | 6 | 37 | |
| GSE60625 | NPLOC4 | 55666 | 6 | 0 | 5 | |
| GSE74703 | NPLOC4 | 55666 | 3 | 3 | 30 | |
| GSE74704 | NPLOC4 | 55666 | 4 | 3 | 13 | |
| TCGA | NPLOC4 | 55666 | 25 | 12 | 59 |
Total number of gains: 104; Total number of losses: 44; Total Number of normals: 340.
Somatic mutations of NPLOC4:
Generating mutation plots.
Highly correlated genes for NPLOC4:
Showing top 20/525 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPLOC4 | PLAGL2 | 0.777936 | 3 | 0 | 3 |
| NPLOC4 | MRPL38 | 0.755825 | 4 | 0 | 4 |
| NPLOC4 | CDC42EP1 | 0.751934 | 3 | 0 | 3 |
| NPLOC4 | SF3B2 | 0.746923 | 3 | 0 | 3 |
| NPLOC4 | UHMK1 | 0.745359 | 3 | 0 | 3 |
| NPLOC4 | ZCCHC17 | 0.740233 | 3 | 0 | 3 |
| NPLOC4 | MFSD3 | 0.721415 | 3 | 0 | 3 |
| NPLOC4 | RCC2 | 0.719728 | 3 | 0 | 3 |
| NPLOC4 | KIAA1257 | 0.718857 | 3 | 0 | 3 |
| NPLOC4 | CLSPN | 0.717448 | 4 | 0 | 4 |
| NPLOC4 | MOB3C | 0.716924 | 3 | 0 | 3 |
| NPLOC4 | CERS5 | 0.715337 | 3 | 0 | 3 |
| NPLOC4 | DAPK3 | 0.7118 | 3 | 0 | 3 |
| NPLOC4 | CCS | 0.706841 | 3 | 0 | 3 |
| NPLOC4 | SNRPD3 | 0.706146 | 3 | 0 | 3 |
| NPLOC4 | KLHDC3 | 0.704222 | 4 | 0 | 3 |
| NPLOC4 | NBAS | 0.698826 | 3 | 0 | 3 |
| NPLOC4 | RSPRY1 | 0.698753 | 4 | 0 | 4 |
| NPLOC4 | RNF2 | 0.697931 | 3 | 0 | 3 |
| NPLOC4 | SLC1A5 | 0.69729 | 4 | 0 | 3 |
For details and further investigation, click here
