| Full name: ubiquinol-cytochrome c reductase binding protein | Alias Symbol: QP-C|QCR7|UQCR6 | ||
| Type: protein-coding gene | Cytoband: 8q22.1 | ||
| Entrez ID: 7381 | HGNC ID: HGNC:12582 | Ensembl Gene: ENSG00000156467 | OMIM ID: 191330 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UQCRB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UQCRB | 7381 | 209066_x_at | 0.0131 | 0.9862 | |
| GSE20347 | UQCRB | 7381 | 209066_x_at | 0.0326 | 0.8336 | |
| GSE23400 | UQCRB | 7381 | 205849_s_at | -0.0156 | 0.8676 | |
| GSE26886 | UQCRB | 7381 | 205849_s_at | -0.0196 | 0.9224 | |
| GSE29001 | UQCRB | 7381 | 209066_x_at | -0.2537 | 0.0866 | |
| GSE38129 | UQCRB | 7381 | 205849_s_at | -0.1009 | 0.3262 | |
| GSE45670 | UQCRB | 7381 | 205849_s_at | -0.0344 | 0.7670 | |
| GSE53622 | UQCRB | 7381 | 60963 | -0.3385 | 0.0000 | |
| GSE53624 | UQCRB | 7381 | 60963 | 0.0270 | 0.7046 | |
| GSE63941 | UQCRB | 7381 | 205849_s_at | -0.2587 | 0.5489 | |
| GSE77861 | UQCRB | 7381 | 209066_x_at | -0.1340 | 0.5146 | |
| GSE97050 | UQCRB | 7381 | A_23_P31671 | -0.5052 | 0.1894 | |
| SRP007169 | UQCRB | 7381 | RNAseq | -0.2927 | 0.3673 | |
| SRP008496 | UQCRB | 7381 | RNAseq | -0.4398 | 0.0612 | |
| SRP064894 | UQCRB | 7381 | RNAseq | -0.0466 | 0.8699 | |
| SRP133303 | UQCRB | 7381 | RNAseq | -0.1499 | 0.3820 | |
| SRP159526 | UQCRB | 7381 | RNAseq | -0.2679 | 0.4434 | |
| SRP193095 | UQCRB | 7381 | RNAseq | -0.8154 | 0.0000 | |
| SRP219564 | UQCRB | 7381 | RNAseq | -0.4961 | 0.2323 | |
| TCGA | UQCRB | 7381 | RNAseq | -0.1323 | 0.0056 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UQCRB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UQCRB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UQCRB | 7381 | 16 | 0 | 14 | |
| GSE20123 | UQCRB | 7381 | 16 | 0 | 14 | |
| GSE43470 | UQCRB | 7381 | 21 | 1 | 21 | |
| GSE46452 | UQCRB | 7381 | 23 | 0 | 36 | |
| GSE47630 | UQCRB | 7381 | 24 | 0 | 16 | |
| GSE54993 | UQCRB | 7381 | 0 | 20 | 50 | |
| GSE54994 | UQCRB | 7381 | 35 | 1 | 17 | |
| GSE60625 | UQCRB | 7381 | 0 | 4 | 7 | |
| GSE74703 | UQCRB | 7381 | 18 | 1 | 17 | |
| GSE74704 | UQCRB | 7381 | 12 | 0 | 8 | |
| TCGA | UQCRB | 7381 | 56 | 1 | 39 |
Total number of gains: 221; Total number of losses: 28; Total Number of normals: 239.
Somatic mutations of UQCRB:
Generating mutation plots.
Highly correlated genes for UQCRB:
Showing top 20/56 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UQCRB | TDRD9 | 0.673619 | 3 | 0 | 3 |
| UQCRB | PCMTD1 | 0.672969 | 4 | 0 | 4 |
| UQCRB | MRPS21 | 0.631263 | 3 | 0 | 3 |
| UQCRB | ARHGEF9 | 0.62365 | 3 | 0 | 3 |
| UQCRB | STOX1 | 0.622692 | 3 | 0 | 3 |
| UQCRB | DYM | 0.616143 | 3 | 0 | 3 |
| UQCRB | COX6C | 0.609395 | 12 | 0 | 10 |
| UQCRB | RAP1A | 0.604139 | 3 | 0 | 3 |
| UQCRB | EIF3E | 0.590191 | 10 | 0 | 7 |
| UQCRB | EIF3H | 0.583313 | 11 | 0 | 8 |
| UQCRB | COX7C | 0.58078 | 9 | 0 | 6 |
| UQCRB | CBX7 | 0.576513 | 4 | 0 | 3 |
| UQCRB | RPL9 | 0.576023 | 7 | 0 | 5 |
| UQCRB | ZBED3 | 0.564 | 5 | 0 | 3 |
| UQCRB | NDUFB5 | 0.562831 | 4 | 0 | 3 |
| UQCRB | MGST3 | 0.562102 | 5 | 0 | 3 |
| UQCRB | HADH | 0.561509 | 5 | 0 | 4 |
| UQCRB | EPB41L4A-AS1 | 0.558756 | 4 | 0 | 3 |
| UQCRB | C1GALT1C1 | 0.558663 | 3 | 0 | 3 |
| UQCRB | PNRC1 | 0.557904 | 5 | 0 | 3 |
For details and further investigation, click here
