| Full name: cytochrome c oxidase subunit 7C | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q14.3 | ||
| Entrez ID: 1350 | HGNC ID: HGNC:2292 | Ensembl Gene: ENSG00000127184 | OMIM ID: 603774 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COX7C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COX7C | 1350 | 201134_x_at | -0.3829 | 0.2209 | |
| GSE20347 | COX7C | 1350 | 201134_x_at | -0.2999 | 0.0056 | |
| GSE23400 | COX7C | 1350 | 201134_x_at | -0.3412 | 0.0000 | |
| GSE26886 | COX7C | 1350 | 201134_x_at | -0.2243 | 0.1079 | |
| GSE29001 | COX7C | 1350 | 201134_x_at | -0.3181 | 0.1532 | |
| GSE38129 | COX7C | 1350 | 201134_x_at | -0.3252 | 0.0009 | |
| GSE45670 | COX7C | 1350 | 201134_x_at | -0.2784 | 0.0185 | |
| GSE53622 | COX7C | 1350 | 85540 | -0.9993 | 0.0000 | |
| GSE53624 | COX7C | 1350 | 85540 | -0.4637 | 0.0000 | |
| GSE63941 | COX7C | 1350 | 201134_x_at | 0.3610 | 0.1039 | |
| GSE77861 | COX7C | 1350 | 201134_x_at | -0.5326 | 0.0107 | |
| GSE97050 | COX7C | 1350 | A_23_P110811 | -0.8321 | 0.1182 | |
| SRP007169 | COX7C | 1350 | RNAseq | -0.8067 | 0.0236 | |
| SRP008496 | COX7C | 1350 | RNAseq | -1.0855 | 0.0001 | |
| SRP064894 | COX7C | 1350 | RNAseq | -0.5930 | 0.0478 | |
| SRP133303 | COX7C | 1350 | RNAseq | -0.3342 | 0.1401 | |
| SRP159526 | COX7C | 1350 | RNAseq | -0.7145 | 0.0507 | |
| SRP193095 | COX7C | 1350 | RNAseq | -1.3976 | 0.0000 | |
| SRP219564 | COX7C | 1350 | RNAseq | -1.0879 | 0.0025 | |
| TCGA | COX7C | 1350 | RNAseq | -0.2106 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by COX7C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COX7C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COX7C | 1350 | 1 | 14 | 15 | |
| GSE20123 | COX7C | 1350 | 1 | 14 | 15 | |
| GSE43470 | COX7C | 1350 | 2 | 10 | 31 | |
| GSE46452 | COX7C | 1350 | 0 | 28 | 31 | |
| GSE47630 | COX7C | 1350 | 1 | 20 | 19 | |
| GSE54993 | COX7C | 1350 | 8 | 1 | 61 | |
| GSE54994 | COX7C | 1350 | 1 | 18 | 34 | |
| GSE60625 | COX7C | 1350 | 0 | 0 | 11 | |
| GSE74703 | COX7C | 1350 | 1 | 8 | 27 | |
| GSE74704 | COX7C | 1350 | 1 | 7 | 12 | |
| TCGA | COX7C | 1350 | 2 | 50 | 44 |
Total number of gains: 18; Total number of losses: 170; Total Number of normals: 300.
Somatic mutations of COX7C:
Generating mutation plots.
Highly correlated genes for COX7C:
Showing top 20/605 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COX7C | CLEC3B | 0.719046 | 3 | 0 | 3 |
| COX7C | MRPS36 | 0.700912 | 8 | 0 | 7 |
| COX7C | RPS23 | 0.688493 | 12 | 0 | 12 |
| COX7C | CYP21A2 | 0.67662 | 3 | 0 | 3 |
| COX7C | SMDT1 | 0.672669 | 4 | 0 | 4 |
| COX7C | EIF4E3 | 0.666454 | 7 | 0 | 6 |
| COX7C | GADD45G | 0.658492 | 4 | 0 | 3 |
| COX7C | NDUFV3 | 0.65188 | 4 | 0 | 3 |
| COX7C | RPL14 | 0.65122 | 8 | 0 | 8 |
| COX7C | UQCRQ | 0.649985 | 12 | 0 | 9 |
| COX7C | MAMDC2-AS1 | 0.649622 | 4 | 0 | 3 |
| COX7C | PCP4L1 | 0.645637 | 4 | 0 | 3 |
| COX7C | FBXO8 | 0.645232 | 5 | 0 | 4 |
| COX7C | CRBN | 0.638766 | 8 | 0 | 8 |
| COX7C | VSIG2 | 0.638404 | 4 | 0 | 3 |
| COX7C | CSTA | 0.635882 | 4 | 0 | 4 |
| COX7C | SREK1IP1 | 0.635865 | 8 | 0 | 6 |
| COX7C | TSLP | 0.635703 | 4 | 0 | 3 |
| COX7C | CIPC | 0.634204 | 6 | 0 | 4 |
| COX7C | NDUFV2 | 0.633779 | 4 | 0 | 3 |
For details and further investigation, click here
