| Full name: NADH:ubiquinone oxidoreductase subunit B5 | Alias Symbol: SGDH|CI-SGDH|MGC12314 | ||
| Type: protein-coding gene | Cytoband: 3q26.33 | ||
| Entrez ID: 4711 | HGNC ID: HGNC:7700 | Ensembl Gene: ENSG00000136521 | OMIM ID: 603841 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of NDUFB5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NDUFB5 | 4711 | 203621_at | 0.1103 | 0.6692 | |
| GSE20347 | NDUFB5 | 4711 | 203621_at | 0.5143 | 0.0035 | |
| GSE23400 | NDUFB5 | 4711 | 203621_at | 0.5157 | 0.0000 | |
| GSE26886 | NDUFB5 | 4711 | 203621_at | 0.0005 | 0.9987 | |
| GSE29001 | NDUFB5 | 4711 | 203621_at | 0.5118 | 0.1617 | |
| GSE38129 | NDUFB5 | 4711 | 203621_at | 0.5714 | 0.0000 | |
| GSE45670 | NDUFB5 | 4711 | 203621_at | 0.4318 | 0.0091 | |
| GSE53622 | NDUFB5 | 4711 | 26354 | -0.3372 | 0.0012 | |
| GSE53624 | NDUFB5 | 4711 | 26354 | 0.4653 | 0.0000 | |
| GSE63941 | NDUFB5 | 4711 | 203621_at | 0.7235 | 0.0685 | |
| GSE77861 | NDUFB5 | 4711 | 203621_at | 0.0856 | 0.8182 | |
| GSE97050 | NDUFB5 | 4711 | A_33_P3296682 | -1.0524 | 0.1133 | |
| SRP007169 | NDUFB5 | 4711 | RNAseq | 1.0092 | 0.0351 | |
| SRP008496 | NDUFB5 | 4711 | RNAseq | 0.7877 | 0.0131 | |
| SRP064894 | NDUFB5 | 4711 | RNAseq | 0.3330 | 0.1021 | |
| SRP133303 | NDUFB5 | 4711 | RNAseq | 0.6076 | 0.0008 | |
| SRP159526 | NDUFB5 | 4711 | RNAseq | 1.1181 | 0.0197 | |
| SRP193095 | NDUFB5 | 4711 | RNAseq | -0.0826 | 0.5857 | |
| SRP219564 | NDUFB5 | 4711 | RNAseq | -0.0459 | 0.8998 | |
| TCGA | NDUFB5 | 4711 | RNAseq | 0.0513 | 0.3302 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by NDUFB5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NDUFB5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NDUFB5 | 4711 | 25 | 0 | 5 | |
| GSE20123 | NDUFB5 | 4711 | 25 | 0 | 5 | |
| GSE43470 | NDUFB5 | 4711 | 24 | 0 | 19 | |
| GSE46452 | NDUFB5 | 4711 | 19 | 1 | 39 | |
| GSE47630 | NDUFB5 | 4711 | 27 | 2 | 11 | |
| GSE54993 | NDUFB5 | 4711 | 1 | 18 | 51 | |
| GSE54994 | NDUFB5 | 4711 | 41 | 0 | 12 | |
| GSE60625 | NDUFB5 | 4711 | 0 | 6 | 5 | |
| GSE74703 | NDUFB5 | 4711 | 20 | 0 | 16 | |
| GSE74704 | NDUFB5 | 4711 | 16 | 0 | 4 | |
| TCGA | NDUFB5 | 4711 | 78 | 0 | 18 |
Total number of gains: 276; Total number of losses: 27; Total Number of normals: 185.
Somatic mutations of NDUFB5:
Generating mutation plots.
Highly correlated genes for NDUFB5:
Showing top 20/588 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NDUFB5 | DNAJC19 | 0.708155 | 8 | 0 | 7 |
| NDUFB5 | PDE8A | 0.703028 | 3 | 0 | 3 |
| NDUFB5 | XPA | 0.678381 | 3 | 0 | 3 |
| NDUFB5 | PARL | 0.673991 | 11 | 0 | 11 |
| NDUFB5 | MRPL47 | 0.670794 | 8 | 0 | 7 |
| NDUFB5 | G3BP2 | 0.670371 | 3 | 0 | 3 |
| NDUFB5 | EIF2B5 | 0.667464 | 8 | 0 | 8 |
| NDUFB5 | PDCD10 | 0.663245 | 9 | 0 | 7 |
| NDUFB5 | FXR1 | 0.661011 | 11 | 0 | 8 |
| NDUFB5 | MFN1 | 0.658448 | 10 | 0 | 8 |
| NDUFB5 | MPPED2 | 0.656286 | 3 | 0 | 3 |
| NDUFB5 | RFC4 | 0.653693 | 10 | 0 | 8 |
| NDUFB5 | UBXN7 | 0.651226 | 5 | 0 | 5 |
| NDUFB5 | RPS6KA3 | 0.649809 | 3 | 0 | 3 |
| NDUFB5 | ANKRD40 | 0.647807 | 4 | 0 | 3 |
| NDUFB5 | ACP1 | 0.645184 | 8 | 0 | 7 |
| NDUFB5 | PIK3CA | 0.643048 | 11 | 0 | 10 |
| NDUFB5 | MRPS22 | 0.641427 | 8 | 0 | 7 |
| NDUFB5 | TUBGCP3 | 0.641146 | 4 | 0 | 4 |
| NDUFB5 | CREG1 | 0.640552 | 3 | 0 | 3 |
For details and further investigation, click here
