USP9X

 

Full name: ubiquitin specific peptidase 9 X-linked Alias Symbol: DFFRX|FAF|MRX99
Type: protein-coding gene Cytoband: Xp11.4
Entrez ID: 8239 HGNC ID: HGNC:12632 Ensembl Gene: ENSG00000124486 OMIM ID: 300072
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 20/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of USP9X:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 USP9X 8239 201100_s_at -0.0296 0.9518
GSE20347 USP9X 8239 201100_s_at -0.3764 0.0001
GSE23400 USP9X 8239 201100_s_at -0.2106 0.0002
GSE26886 USP9X 8239 201100_s_at -0.0833 0.7001
GSE29001 USP9X 8239 201100_s_at -0.5236 0.0146
GSE38129 USP9X 8239 201100_s_at -0.4509 0.0000
GSE45670 USP9X 8239 201100_s_at -0.1458 0.4775
GSE53622 USP9X 8239 40458 -1.0856 0.0000
GSE53624 USP9X 8239 40458 -0.9256 0.0000
GSE63941 USP9X 8239 201100_s_at -0.7596 0.0491
GSE77861 USP9X 8239 201100_s_at -0.2109 0.3034
GSE97050 USP9X 8239 A_33_P3387771 -0.6393 0.1559
SRP007169 USP9X 8239 RNAseq -0.0265 0.9429
SRP008496 USP9X 8239 RNAseq 0.2150 0.4138
SRP064894 USP9X 8239 RNAseq -0.4011 0.0388
SRP133303 USP9X 8239 RNAseq 0.1200 0.5451
SRP159526 USP9X 8239 RNAseq -0.2981 0.0565
SRP193095 USP9X 8239 RNAseq -0.1464 0.0613
SRP219564 USP9X 8239 RNAseq -0.2072 0.4834
TCGA USP9X 8239 RNAseq -0.0931 0.0301

Upregulated datasets: 0; Downregulated datasets: 1.  


 

Survival by USP9X expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of USP9X:

 

No record found for this gene.


 

Somatic mutations of USP9X:

 

Generating mutation plots.

 

Highly correlated genes for USP9X:

 

Showing top 20/980 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
USP9XCLEC3B0.797964303
USP9XUBXN100.793876303
USP9XMAP90.757867303
USP9XCYP21A20.749037303
USP9XCCDC1590.741652404
USP9XRERG0.739822404
USP9XHNRNPH30.736625303
USP9XRGS7BP0.726035303
USP9XABCG20.718828303
USP9XDZIP30.718251303
USP9XLATS20.716756303
USP9XHNRNPA00.704777303
USP9XTMOD20.704347404
USP9XANGPTL10.701706404
USP9XCFL20.701212404
USP9XANAPC160.699825404
USP9XCCDC30.694914303
USP9XMAMDC20.692449404
USP9XPI160.692263404
USP9XCLU0.687681303

For details and further investigation, click here