UTP18

 

Full name: UTP18 small subunit processome component Alias Symbol: CGI-48
Type: protein-coding gene Cytoband: 17q21.33
Entrez ID: 51096 HGNC ID: HGNC:24274 Ensembl Gene: ENSG00000011260 OMIM ID: 612816
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of UTP18:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 UTP18 51096 203721_s_at 0.3888 0.2342
GSE20347 UTP18 51096 203721_s_at 0.3448 0.0595
GSE23400 UTP18 51096 203721_s_at 0.7650 0.0000
GSE26886 UTP18 51096 203721_s_at 0.3043 0.0573
GSE29001 UTP18 51096 203721_s_at 0.4222 0.2699
GSE38129 UTP18 51096 203721_s_at 0.6522 0.0000
GSE45670 UTP18 51096 203721_s_at 0.0577 0.8019
GSE53622 UTP18 51096 75367 0.4246 0.0000
GSE53624 UTP18 51096 75367 0.4492 0.0000
GSE63941 UTP18 51096 203721_s_at 0.7700 0.0024
GSE77861 UTP18 51096 203721_s_at 0.6216 0.0106
GSE97050 UTP18 51096 A_23_P130020 0.5543 0.2575
SRP007169 UTP18 51096 RNAseq 1.4866 0.0011
SRP008496 UTP18 51096 RNAseq 1.1713 0.0002
SRP064894 UTP18 51096 RNAseq 0.3022 0.0601
SRP133303 UTP18 51096 RNAseq 0.4456 0.0244
SRP159526 UTP18 51096 RNAseq 0.3467 0.2080
SRP193095 UTP18 51096 RNAseq 0.0049 0.9627
SRP219564 UTP18 51096 RNAseq 0.2231 0.5562
TCGA UTP18 51096 RNAseq 0.2499 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by UTP18 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of UTP18:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 UTP18 51096 5 2 23
GSE20123 UTP18 51096 5 2 23
GSE43470 UTP18 51096 2 2 39
GSE46452 UTP18 51096 32 0 27
GSE47630 UTP18 51096 9 0 31
GSE54993 UTP18 51096 2 4 64
GSE54994 UTP18 51096 8 6 39
GSE60625 UTP18 51096 4 0 7
GSE74703 UTP18 51096 2 2 32
GSE74704 UTP18 51096 4 1 15
TCGA UTP18 51096 26 8 62

Total number of gains: 99; Total number of losses: 27; Total Number of normals: 362.  

 

Somatic mutations of UTP18:

 

Generating mutation plots.

 

Highly correlated genes for UTP18:

 

Showing top 20/1244 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
UTP18FAM110A0.740833303
UTP18NME10.71639912010
UTP18UCK20.71015303
UTP18BRI3BP0.703968303
UTP18LRRC590.6947341008
UTP18CCNB10.6909781008
UTP18PBK0.6824691109
UTP18BUB1B0.678691707
UTP18PRKDC0.6780841009
UTP18BAIAP2L10.674601404
UTP18DTYMK0.673019808
UTP18NXT20.669545908
UTP18CDCA20.666406403
UTP18RAN0.66605212010
UTP18ILF20.66579212010
UTP18SMC60.663923807
UTP18NOL110.663612010
UTP18PSMB30.663493908
UTP18FANCB0.662967403
UTP18GART0.662753908

For details and further investigation, click here