SMC6

 

Full name: structural maintenance of chromosomes 6 Alias Symbol: FLJ22116
Type: protein-coding gene Cytoband: 2p24.2
Entrez ID: 79677 HGNC ID: HGNC:20466 Ensembl Gene: ENSG00000163029 OMIM ID: 609387
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of SMC6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SMC6 79677 218781_at 0.3672 0.2143
GSE20347 SMC6 79677 218781_at 0.9178 0.0003
GSE23400 SMC6 79677 218781_at 0.8122 0.0000
GSE26886 SMC6 79677 218781_at 0.5937 0.0098
GSE29001 SMC6 79677 218781_at 0.7104 0.0234
GSE38129 SMC6 79677 218781_at 0.9340 0.0000
GSE45670 SMC6 79677 218781_at 0.5785 0.0030
GSE53622 SMC6 79677 106981 0.6586 0.0000
GSE53624 SMC6 79677 106981 0.7198 0.0000
GSE63941 SMC6 79677 218781_at 0.8929 0.1649
GSE77861 SMC6 79677 218781_at 0.5930 0.1109
GSE97050 SMC6 79677 A_23_P209962 0.5633 0.1805
SRP007169 SMC6 79677 RNAseq 1.3255 0.0007
SRP008496 SMC6 79677 RNAseq 1.6651 0.0000
SRP064894 SMC6 79677 RNAseq 0.5338 0.0389
SRP133303 SMC6 79677 RNAseq 0.6435 0.0004
SRP159526 SMC6 79677 RNAseq 0.4306 0.0644
SRP193095 SMC6 79677 RNAseq 0.4792 0.0003
SRP219564 SMC6 79677 RNAseq -0.0214 0.9634
TCGA SMC6 79677 RNAseq 0.3625 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by SMC6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SMC6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SMC6 79677 10 2 18
GSE20123 SMC6 79677 10 2 18
GSE43470 SMC6 79677 2 0 41
GSE46452 SMC6 79677 3 4 52
GSE47630 SMC6 79677 7 0 33
GSE54993 SMC6 79677 0 7 63
GSE54994 SMC6 79677 10 0 43
GSE60625 SMC6 79677 0 3 8
GSE74703 SMC6 79677 2 0 34
GSE74704 SMC6 79677 9 2 9
TCGA SMC6 79677 36 3 57

Total number of gains: 89; Total number of losses: 23; Total Number of normals: 376.  

 

Somatic mutations of SMC6:

 

Generating mutation plots.

 

Highly correlated genes for SMC6:

 

Showing top 20/1650 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SMC6CD140.780178303
SMC6MASTL0.768882505
SMC6CEP550.758998909
SMC6SLC35A50.742886303
SMC6LMNB20.735639909
SMC6UCK20.734109303
SMC6PSME40.7256911011
SMC6ATAD20.7256071009
SMC6TTL0.725316605
SMC6CKAP2L0.714149606
SMC6SLC44A10.711608605
SMC6DSCC10.708359808
SMC6CAD0.70781712011
SMC6FANCD20.706893505
SMC6RPA20.704017404
SMC6ACER30.703834303
SMC6MTHFD1L0.702647303
SMC6CDK10.70188110010
SMC6DDX39A0.70112411010
SMC6KNSTRN0.699956504

For details and further investigation, click here