| Full name: BUB1 mitotic checkpoint serine/threonine kinase B | Alias Symbol: BUBR1|MAD3L|Bub1A|SSK1 | ||
| Type: protein-coding gene | Cytoband: 15q15.1 | ||
| Entrez ID: 701 | HGNC ID: HGNC:1149 | Ensembl Gene: ENSG00000156970 | OMIM ID: 602860 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
BUB1B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa05166 | HTLV-I infection |
Expression of BUB1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BUB1B | 701 | 203755_at | 1.3263 | 0.0657 | |
| GSE20347 | BUB1B | 701 | 203755_at | 1.5745 | 0.0000 | |
| GSE23400 | BUB1B | 701 | 203755_at | 1.6473 | 0.0000 | |
| GSE26886 | BUB1B | 701 | 203755_at | 0.6175 | 0.0487 | |
| GSE29001 | BUB1B | 701 | 203755_at | 1.2796 | 0.0003 | |
| GSE38129 | BUB1B | 701 | 203755_at | 2.0124 | 0.0000 | |
| GSE45670 | BUB1B | 701 | 203755_at | 1.2465 | 0.0000 | |
| GSE63941 | BUB1B | 701 | 203755_at | 2.9529 | 0.0000 | |
| GSE77861 | BUB1B | 701 | 203755_at | 1.0738 | 0.0140 | |
| GSE97050 | BUB1B | 701 | A_23_P163481 | 1.1703 | 0.1578 | |
| SRP007169 | BUB1B | 701 | RNAseq | 2.5731 | 0.0000 | |
| SRP008496 | BUB1B | 701 | RNAseq | 2.1254 | 0.0000 | |
| SRP064894 | BUB1B | 701 | RNAseq | 1.2521 | 0.0003 | |
| SRP133303 | BUB1B | 701 | RNAseq | 1.5936 | 0.0000 | |
| SRP159526 | BUB1B | 701 | RNAseq | 1.3064 | 0.0000 | |
| SRP193095 | BUB1B | 701 | RNAseq | 0.9837 | 0.0000 | |
| SRP219564 | BUB1B | 701 | RNAseq | 0.7501 | 0.2949 | |
| TCGA | BUB1B | 701 | RNAseq | 1.3245 | 0.0000 |
Upregulated datasets: 13; Downregulated datasets: 0.
Survival by BUB1B expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of BUB1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BUB1B | 701 | 4 | 5 | 21 | |
| GSE20123 | BUB1B | 701 | 4 | 5 | 21 | |
| GSE43470 | BUB1B | 701 | 4 | 6 | 33 | |
| GSE46452 | BUB1B | 701 | 3 | 7 | 49 | |
| GSE47630 | BUB1B | 701 | 8 | 11 | 21 | |
| GSE54993 | BUB1B | 701 | 4 | 6 | 60 | |
| GSE54994 | BUB1B | 701 | 5 | 7 | 41 | |
| GSE60625 | BUB1B | 701 | 4 | 0 | 7 | |
| GSE74703 | BUB1B | 701 | 4 | 5 | 27 | |
| GSE74704 | BUB1B | 701 | 3 | 3 | 14 | |
| TCGA | BUB1B | 701 | 11 | 17 | 68 |
Total number of gains: 54; Total number of losses: 72; Total Number of normals: 362.
Somatic mutations of BUB1B:
Generating mutation plots.
Highly correlated genes for BUB1B:
Showing top 20/891 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BUB1B | NUSAP1 | 0.904859 | 10 | 0 | 10 |
| BUB1B | CENPF | 0.892045 | 9 | 0 | 9 |
| BUB1B | TTK | 0.886824 | 9 | 0 | 9 |
| BUB1B | CDC20 | 0.879634 | 10 | 0 | 10 |
| BUB1B | MTFR2 | 0.872105 | 5 | 0 | 5 |
| BUB1B | CCNB2 | 0.866922 | 9 | 0 | 8 |
| BUB1B | KIF18B | 0.865193 | 10 | 0 | 10 |
| BUB1B | KIF4A | 0.863902 | 11 | 0 | 11 |
| BUB1B | PRC1 | 0.86326 | 10 | 0 | 10 |
| BUB1B | NCAPH | 0.857734 | 9 | 0 | 9 |
| BUB1B | ASPM | 0.851295 | 10 | 0 | 9 |
| BUB1B | KIF14 | 0.851039 | 10 | 0 | 10 |
| BUB1B | CENPN | 0.848829 | 9 | 0 | 9 |
| BUB1B | CDK1 | 0.848596 | 10 | 0 | 10 |
| BUB1B | HJURP | 0.847159 | 9 | 0 | 9 |
| BUB1B | CEP55 | 0.846513 | 10 | 0 | 9 |
| BUB1B | TOP2A | 0.843526 | 10 | 0 | 10 |
| BUB1B | NEK2 | 0.843254 | 10 | 0 | 9 |
| BUB1B | HMMR | 0.842816 | 9 | 0 | 9 |
| BUB1B | TPX2 | 0.836702 | 10 | 0 | 10 |
For details and further investigation, click here
