UTP20

 

Full name: UTP20 small subunit processome component Alias Symbol: DRIM|1A6/DRIM
Type: protein-coding gene Cytoband: 12q23.2
Entrez ID: 27340 HGNC ID: HGNC:17897 Ensembl Gene: ENSG00000120800 OMIM ID: 612822
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of UTP20:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 UTP20 27340 209725_at 0.6956 0.0913
GSE20347 UTP20 27340 209725_at 0.1964 0.1898
GSE23400 UTP20 27340 209725_at 0.1873 0.0000
GSE26886 UTP20 27340 209725_at 0.2559 0.2022
GSE29001 UTP20 27340 209725_at 0.3341 0.5620
GSE38129 UTP20 27340 209725_at 0.5265 0.0125
GSE45670 UTP20 27340 209725_at 0.4292 0.0032
GSE53622 UTP20 27340 109166 0.5251 0.0000
GSE53624 UTP20 27340 109166 0.7792 0.0000
GSE63941 UTP20 27340 209725_at -1.0324 0.0344
GSE77861 UTP20 27340 209725_at 0.4208 0.0073
GSE97050 UTP20 27340 A_23_P162525 0.3948 0.1460
SRP007169 UTP20 27340 RNAseq 1.9052 0.0002
SRP008496 UTP20 27340 RNAseq 2.0146 0.0000
SRP064894 UTP20 27340 RNAseq 0.1786 0.3830
SRP133303 UTP20 27340 RNAseq 0.6355 0.0015
SRP159526 UTP20 27340 RNAseq 0.3490 0.1605
SRP193095 UTP20 27340 RNAseq 0.3335 0.0002
SRP219564 UTP20 27340 RNAseq -0.0107 0.9620
TCGA UTP20 27340 RNAseq 0.1282 0.0281

Upregulated datasets: 2; Downregulated datasets: 1.  

 

Survival by UTP20 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of UTP20:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 UTP20 27340 2 2 26
GSE20123 UTP20 27340 2 2 26
GSE43470 UTP20 27340 2 0 41
GSE46452 UTP20 27340 9 1 49
GSE47630 UTP20 27340 9 1 30
GSE54993 UTP20 27340 0 5 65
GSE54994 UTP20 27340 4 2 47
GSE60625 UTP20 27340 0 0 11
GSE74703 UTP20 27340 2 0 34
GSE74704 UTP20 27340 1 2 17
TCGA UTP20 27340 19 10 67

Total number of gains: 50; Total number of losses: 25; Total Number of normals: 413.  

 

Somatic mutations of UTP20:

 

Generating mutation plots.

 

Highly correlated genes for UTP20:

 

Showing top 20/988 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
UTP20SPSB20.815468303
UTP20TMEM63B0.797142303
UTP20FIP1L10.781924303
UTP20METAP1D0.778703303
UTP20XAB20.764507303
UTP20SPATA50.75381303
UTP20CDCA20.74043404
UTP20RIOK10.740265606
UTP20CDC42EP40.740078303
UTP20PLEKHA30.738117303
UTP20DDX550.732501606
UTP20ANKRD110.731484303
UTP20ZBTB90.730848505
UTP20ZXDC0.729833404
UTP20CCDC1170.725845303
UTP20PIGM0.72529303
UTP20KBTBD60.723073404
UTP20ZCCHC30.722167303
UTP20WDR700.718247303
UTP20SASS60.714735404

For details and further investigation, click here