| Full name: tousled like kinase 2 | Alias Symbol: PKU-ALPHA|MGC44450 | ||
| Type: protein-coding gene | Cytoband: 17q23 | ||
| Entrez ID: 11011 | HGNC ID: HGNC:11842 | Ensembl Gene: ENSG00000146872 | OMIM ID: 608439 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TLK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLK2 | 11011 | 212997_s_at | 0.0214 | 0.9485 | |
| GSE20347 | TLK2 | 11011 | 212986_s_at | 0.0996 | 0.5248 | |
| GSE23400 | TLK2 | 11011 | 212986_s_at | 0.0588 | 0.1181 | |
| GSE26886 | TLK2 | 11011 | 212997_s_at | 0.1923 | 0.1584 | |
| GSE29001 | TLK2 | 11011 | 212997_s_at | 0.4382 | 0.0065 | |
| GSE38129 | TLK2 | 11011 | 212997_s_at | 0.3647 | 0.0009 | |
| GSE45670 | TLK2 | 11011 | 212997_s_at | 0.1743 | 0.2611 | |
| GSE53622 | TLK2 | 11011 | 45381 | 0.0588 | 0.3511 | |
| GSE53624 | TLK2 | 11011 | 45381 | 0.1474 | 0.0378 | |
| GSE63941 | TLK2 | 11011 | 212997_s_at | -0.1126 | 0.8190 | |
| GSE77861 | TLK2 | 11011 | 212997_s_at | 0.5051 | 0.0022 | |
| GSE97050 | TLK2 | 11011 | A_33_P3328937 | -0.1385 | 0.5294 | |
| SRP007169 | TLK2 | 11011 | RNAseq | 0.8180 | 0.0216 | |
| SRP008496 | TLK2 | 11011 | RNAseq | 1.1105 | 0.0000 | |
| SRP064894 | TLK2 | 11011 | RNAseq | 0.2050 | 0.0751 | |
| SRP133303 | TLK2 | 11011 | RNAseq | 0.3220 | 0.0297 | |
| SRP159526 | TLK2 | 11011 | RNAseq | 0.1931 | 0.2493 | |
| SRP193095 | TLK2 | 11011 | RNAseq | 0.1079 | 0.0823 | |
| SRP219564 | TLK2 | 11011 | RNAseq | -0.0532 | 0.8227 | |
| TCGA | TLK2 | 11011 | RNAseq | 0.0797 | 0.1398 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TLK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TLK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLK2 | 11011 | 4 | 1 | 25 | |
| GSE20123 | TLK2 | 11011 | 4 | 1 | 25 | |
| GSE43470 | TLK2 | 11011 | 5 | 0 | 38 | |
| GSE46452 | TLK2 | 11011 | 31 | 0 | 28 | |
| GSE47630 | TLK2 | 11011 | 7 | 1 | 32 | |
| GSE54993 | TLK2 | 11011 | 2 | 5 | 63 | |
| GSE54994 | TLK2 | 11011 | 9 | 5 | 39 | |
| GSE60625 | TLK2 | 11011 | 4 | 0 | 7 | |
| GSE74703 | TLK2 | 11011 | 5 | 0 | 31 | |
| GSE74704 | TLK2 | 11011 | 3 | 1 | 16 | |
| TCGA | TLK2 | 11011 | 31 | 7 | 58 |
Total number of gains: 105; Total number of losses: 21; Total Number of normals: 362.
Somatic mutations of TLK2:
Generating mutation plots.
Highly correlated genes for TLK2:
Showing top 20/573 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLK2 | DDB1 | 0.782729 | 3 | 0 | 3 |
| TLK2 | PIGS | 0.777097 | 4 | 0 | 4 |
| TLK2 | COL15A1 | 0.772046 | 3 | 0 | 3 |
| TLK2 | HAUS1 | 0.764415 | 3 | 0 | 3 |
| TLK2 | CEP63 | 0.747724 | 3 | 0 | 3 |
| TLK2 | ZNF703 | 0.727494 | 3 | 0 | 3 |
| TLK2 | VKORC1 | 0.723787 | 3 | 0 | 3 |
| TLK2 | PRRX1 | 0.71701 | 3 | 0 | 3 |
| TLK2 | RRAS2 | 0.713691 | 4 | 0 | 3 |
| TLK2 | FEZ2 | 0.707267 | 4 | 0 | 4 |
| TLK2 | PRNP | 0.706188 | 4 | 0 | 4 |
| TLK2 | RAVER1 | 0.704559 | 3 | 0 | 3 |
| TLK2 | RAP1B | 0.702107 | 4 | 0 | 3 |
| TLK2 | TMX3 | 0.698049 | 3 | 0 | 3 |
| TLK2 | WWTR1 | 0.697638 | 3 | 0 | 3 |
| TLK2 | FBN1 | 0.694836 | 3 | 0 | 3 |
| TLK2 | NEDD1 | 0.689998 | 4 | 0 | 3 |
| TLK2 | SRSF6 | 0.689699 | 3 | 0 | 3 |
| TLK2 | LSG1 | 0.689582 | 4 | 0 | 4 |
| TLK2 | VPS37C | 0.688817 | 3 | 0 | 3 |
For details and further investigation, click here
