| Full name: signal peptide peptidase like 3 | Alias Symbol: IMP2|PSL4|MGC90402|MGC126674|MGC126676|DKFZP586C1324 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 121665 | HGNC ID: HGNC:30424 | Ensembl Gene: ENSG00000157837 | OMIM ID: 608240 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SPPL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPPL3 | 121665 | 224639_at | -0.0388 | 0.9518 | |
| GSE26886 | SPPL3 | 121665 | 224639_at | -0.6730 | 0.0039 | |
| GSE45670 | SPPL3 | 121665 | 224639_at | -0.0356 | 0.8512 | |
| GSE53622 | SPPL3 | 121665 | 123245 | -0.0252 | 0.7998 | |
| GSE53624 | SPPL3 | 121665 | 123245 | -0.1428 | 0.0279 | |
| GSE63941 | SPPL3 | 121665 | 224640_at | 0.3043 | 0.1868 | |
| GSE77861 | SPPL3 | 121665 | 224639_at | 0.0253 | 0.9157 | |
| GSE97050 | SPPL3 | 121665 | A_23_P427622 | 0.0447 | 0.8890 | |
| SRP007169 | SPPL3 | 121665 | RNAseq | -0.4637 | 0.2167 | |
| SRP008496 | SPPL3 | 121665 | RNAseq | -0.5426 | 0.0121 | |
| SRP064894 | SPPL3 | 121665 | RNAseq | -0.3076 | 0.0205 | |
| SRP133303 | SPPL3 | 121665 | RNAseq | -0.3824 | 0.0000 | |
| SRP159526 | SPPL3 | 121665 | RNAseq | -0.3323 | 0.1753 | |
| SRP193095 | SPPL3 | 121665 | RNAseq | -0.4867 | 0.0002 | |
| SRP219564 | SPPL3 | 121665 | RNAseq | -0.3465 | 0.3047 | |
| TCGA | SPPL3 | 121665 | RNAseq | 0.1459 | 0.0106 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPPL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPPL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPPL3 | 121665 | 6 | 2 | 22 | |
| GSE20123 | SPPL3 | 121665 | 6 | 2 | 22 | |
| GSE43470 | SPPL3 | 121665 | 2 | 2 | 39 | |
| GSE46452 | SPPL3 | 121665 | 9 | 1 | 49 | |
| GSE47630 | SPPL3 | 121665 | 9 | 3 | 28 | |
| GSE54993 | SPPL3 | 121665 | 0 | 5 | 65 | |
| GSE54994 | SPPL3 | 121665 | 7 | 6 | 40 | |
| GSE60625 | SPPL3 | 121665 | 0 | 0 | 11 | |
| GSE74703 | SPPL3 | 121665 | 2 | 1 | 33 | |
| GSE74704 | SPPL3 | 121665 | 3 | 2 | 15 | |
| TCGA | SPPL3 | 121665 | 20 | 12 | 64 |
Total number of gains: 64; Total number of losses: 36; Total Number of normals: 388.
Somatic mutations of SPPL3:
Generating mutation plots.
Highly correlated genes for SPPL3:
Showing top 20/263 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPPL3 | MBD1 | 0.768972 | 3 | 0 | 3 |
| SPPL3 | VPS52 | 0.767623 | 3 | 0 | 3 |
| SPPL3 | PPCS | 0.765055 | 3 | 0 | 3 |
| SPPL3 | SNX4 | 0.76274 | 3 | 0 | 3 |
| SPPL3 | MRPS10 | 0.757943 | 3 | 0 | 3 |
| SPPL3 | STAM2 | 0.743832 | 3 | 0 | 3 |
| SPPL3 | RBM27 | 0.735897 | 3 | 0 | 3 |
| SPPL3 | RUFY3 | 0.732329 | 3 | 0 | 3 |
| SPPL3 | TBC1D23 | 0.718058 | 4 | 0 | 4 |
| SPPL3 | SACM1L | 0.70778 | 3 | 0 | 3 |
| SPPL3 | OSBPL8 | 0.70446 | 3 | 0 | 3 |
| SPPL3 | MTMR3 | 0.70333 | 3 | 0 | 3 |
| SPPL3 | NUDT9 | 0.697668 | 3 | 0 | 3 |
| SPPL3 | ELMO2 | 0.694578 | 4 | 0 | 3 |
| SPPL3 | RHBDF1 | 0.693945 | 3 | 0 | 3 |
| SPPL3 | LAMTOR3 | 0.693198 | 4 | 0 | 3 |
| SPPL3 | CPEB4 | 0.689017 | 3 | 0 | 3 |
| SPPL3 | HEATR5B | 0.686071 | 3 | 0 | 3 |
| SPPL3 | LNX2 | 0.685367 | 4 | 0 | 3 |
| SPPL3 | NDUFS2 | 0.683296 | 3 | 0 | 3 |
For details and further investigation, click here
