| Full name: VPS8 subunit of CORVET complex | Alias Symbol: FLJ32099 | ||
| Type: protein-coding gene | Cytoband: 3q27.2 | ||
| Entrez ID: 23355 | HGNC ID: HGNC:29122 | Ensembl Gene: ENSG00000156931 | OMIM ID: 618366 |
| Drug and gene relationship at DGIdb | |||
Expression of VPS8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS8 | 23355 | 209553_at | 0.1125 | 0.6064 | |
| GSE20347 | VPS8 | 23355 | 209553_at | 0.2938 | 0.0236 | |
| GSE23400 | VPS8 | 23355 | 209553_at | 0.1940 | 0.0027 | |
| GSE26886 | VPS8 | 23355 | 209553_at | 0.4677 | 0.0265 | |
| GSE29001 | VPS8 | 23355 | 209553_at | 0.1818 | 0.4226 | |
| GSE38129 | VPS8 | 23355 | 209553_at | 0.3192 | 0.0011 | |
| GSE45670 | VPS8 | 23355 | 209553_at | 0.3351 | 0.0323 | |
| GSE53622 | VPS8 | 23355 | 966 | 0.3831 | 0.0000 | |
| GSE53624 | VPS8 | 23355 | 966 | 0.1724 | 0.0036 | |
| GSE63941 | VPS8 | 23355 | 209553_at | 0.0860 | 0.8779 | |
| GSE77861 | VPS8 | 23355 | 209553_at | 0.3027 | 0.2855 | |
| GSE97050 | VPS8 | 23355 | A_24_P357709 | 0.1669 | 0.4884 | |
| SRP007169 | VPS8 | 23355 | RNAseq | 0.4161 | 0.2414 | |
| SRP008496 | VPS8 | 23355 | RNAseq | 0.4890 | 0.0366 | |
| SRP064894 | VPS8 | 23355 | RNAseq | 0.5548 | 0.0031 | |
| SRP133303 | VPS8 | 23355 | RNAseq | 0.7626 | 0.0000 | |
| SRP159526 | VPS8 | 23355 | RNAseq | 0.6920 | 0.0091 | |
| SRP193095 | VPS8 | 23355 | RNAseq | 0.3498 | 0.0002 | |
| SRP219564 | VPS8 | 23355 | RNAseq | 0.1998 | 0.5946 | |
| TCGA | VPS8 | 23355 | RNAseq | 0.0062 | 0.9081 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by VPS8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS8 | 23355 | 25 | 0 | 5 | |
| GSE20123 | VPS8 | 23355 | 25 | 0 | 5 | |
| GSE43470 | VPS8 | 23355 | 24 | 0 | 19 | |
| GSE46452 | VPS8 | 23355 | 19 | 1 | 39 | |
| GSE47630 | VPS8 | 23355 | 27 | 2 | 11 | |
| GSE54993 | VPS8 | 23355 | 1 | 19 | 50 | |
| GSE54994 | VPS8 | 23355 | 40 | 0 | 13 | |
| GSE60625 | VPS8 | 23355 | 0 | 6 | 5 | |
| GSE74703 | VPS8 | 23355 | 20 | 0 | 16 | |
| GSE74704 | VPS8 | 23355 | 17 | 0 | 3 | |
| TCGA | VPS8 | 23355 | 77 | 0 | 19 |
Total number of gains: 275; Total number of losses: 28; Total Number of normals: 185.
Somatic mutations of VPS8:
Generating mutation plots.
Highly correlated genes for VPS8:
Showing top 20/408 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS8 | CDK9 | 0.757664 | 3 | 0 | 3 |
| VPS8 | ZZZ3 | 0.708115 | 3 | 0 | 3 |
| VPS8 | COMMD2 | 0.671875 | 4 | 0 | 3 |
| VPS8 | ZGPAT | 0.67154 | 3 | 0 | 3 |
| VPS8 | LRCH3 | 0.662677 | 6 | 0 | 5 |
| VPS8 | TFDP2 | 0.659886 | 7 | 0 | 7 |
| VPS8 | IFT140 | 0.659593 | 5 | 0 | 4 |
| VPS8 | TRPM4 | 0.659312 | 4 | 0 | 4 |
| VPS8 | PIP4K2B | 0.659031 | 4 | 0 | 4 |
| VPS8 | MRPL47 | 0.658081 | 7 | 0 | 7 |
| VPS8 | MAP3K13 | 0.656788 | 6 | 0 | 5 |
| VPS8 | PPP1R16A | 0.652918 | 3 | 0 | 3 |
| VPS8 | RAB3GAP1 | 0.652881 | 3 | 0 | 3 |
| VPS8 | ZNF766 | 0.652664 | 3 | 0 | 3 |
| VPS8 | CCDC18 | 0.649457 | 3 | 0 | 3 |
| VPS8 | RRAS2 | 0.647212 | 4 | 0 | 4 |
| VPS8 | MTBP | 0.644263 | 4 | 0 | 3 |
| VPS8 | MYNN | 0.642509 | 8 | 0 | 7 |
| VPS8 | TAOK1 | 0.638851 | 3 | 0 | 3 |
| VPS8 | PRKRA | 0.637879 | 3 | 0 | 3 |
For details and further investigation, click here
