| Full name: WW domain binding protein 11 | Alias Symbol: NPWBP|SIPP1|PPP1R165 | ||
| Type: protein-coding gene | Cytoband: 12p12.3 | ||
| Entrez ID: 51729 | HGNC ID: HGNC:16461 | Ensembl Gene: ENSG00000084463 | OMIM ID: 618083 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of WBP11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WBP11 | 51729 | 217822_at | 0.2666 | 0.5143 | |
| GSE20347 | WBP11 | 51729 | 217822_at | 0.5010 | 0.0003 | |
| GSE23400 | WBP11 | 51729 | 217822_at | 0.7034 | 0.0000 | |
| GSE26886 | WBP11 | 51729 | 217822_at | 0.6054 | 0.0153 | |
| GSE29001 | WBP11 | 51729 | 217822_at | 0.7369 | 0.0042 | |
| GSE38129 | WBP11 | 51729 | 217822_at | 0.4097 | 0.0001 | |
| GSE45670 | WBP11 | 51729 | 217822_at | 0.2886 | 0.1157 | |
| GSE53622 | WBP11 | 51729 | 12852 | 0.4747 | 0.0000 | |
| GSE53624 | WBP11 | 51729 | 12852 | 0.5980 | 0.0000 | |
| GSE63941 | WBP11 | 51729 | 217822_at | 0.9186 | 0.0242 | |
| GSE77861 | WBP11 | 51729 | 217822_at | 0.5646 | 0.0311 | |
| GSE97050 | WBP11 | 51729 | A_33_P3334037 | 0.0781 | 0.7829 | |
| SRP007169 | WBP11 | 51729 | RNAseq | 1.3177 | 0.0046 | |
| SRP008496 | WBP11 | 51729 | RNAseq | 1.1923 | 0.0001 | |
| SRP064894 | WBP11 | 51729 | RNAseq | -0.0567 | 0.6058 | |
| SRP133303 | WBP11 | 51729 | RNAseq | 0.5752 | 0.0009 | |
| SRP159526 | WBP11 | 51729 | RNAseq | 0.4074 | 0.0598 | |
| SRP193095 | WBP11 | 51729 | RNAseq | 0.3437 | 0.0001 | |
| SRP219564 | WBP11 | 51729 | RNAseq | 0.1229 | 0.6340 | |
| TCGA | WBP11 | 51729 | RNAseq | 0.1177 | 0.0112 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by WBP11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WBP11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WBP11 | 51729 | 6 | 2 | 22 | |
| GSE20123 | WBP11 | 51729 | 6 | 2 | 22 | |
| GSE43470 | WBP11 | 51729 | 9 | 4 | 30 | |
| GSE46452 | WBP11 | 51729 | 10 | 1 | 48 | |
| GSE47630 | WBP11 | 51729 | 14 | 1 | 25 | |
| GSE54993 | WBP11 | 51729 | 1 | 9 | 60 | |
| GSE54994 | WBP11 | 51729 | 10 | 2 | 41 | |
| GSE60625 | WBP11 | 51729 | 0 | 1 | 10 | |
| GSE74703 | WBP11 | 51729 | 9 | 3 | 24 | |
| GSE74704 | WBP11 | 51729 | 4 | 1 | 15 | |
| TCGA | WBP11 | 51729 | 41 | 5 | 50 |
Total number of gains: 110; Total number of losses: 31; Total Number of normals: 347.
Somatic mutations of WBP11:
Generating mutation plots.
Highly correlated genes for WBP11:
Showing top 20/1522 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WBP11 | STRAP | 0.780676 | 13 | 0 | 12 |
| WBP11 | GRB2 | 0.776324 | 3 | 0 | 3 |
| WBP11 | ABHD2 | 0.77427 | 3 | 0 | 3 |
| WBP11 | LRP5L | 0.771764 | 3 | 0 | 3 |
| WBP11 | CTPS2 | 0.759008 | 3 | 0 | 3 |
| WBP11 | RAD51AP1 | 0.75835 | 12 | 0 | 12 |
| WBP11 | MRPL38 | 0.74521 | 4 | 0 | 4 |
| WBP11 | MAGOHB | 0.741087 | 11 | 0 | 10 |
| WBP11 | FOXM1 | 0.74082 | 11 | 0 | 11 |
| WBP11 | SFT2D3 | 0.731085 | 4 | 0 | 4 |
| WBP11 | ZNF384 | 0.715566 | 10 | 0 | 10 |
| WBP11 | SRI | 0.71194 | 3 | 0 | 3 |
| WBP11 | ALG10 | 0.707845 | 8 | 0 | 7 |
| WBP11 | M6PR | 0.707664 | 9 | 0 | 7 |
| WBP11 | PHB2 | 0.705457 | 13 | 0 | 12 |
| WBP11 | NCAPD2 | 0.704201 | 13 | 0 | 12 |
| WBP11 | MMS22L | 0.703168 | 3 | 0 | 3 |
| WBP11 | KLF13 | 0.702638 | 4 | 0 | 4 |
| WBP11 | GNG10 | 0.698319 | 3 | 0 | 3 |
| WBP11 | TET1 | 0.697478 | 3 | 0 | 3 |
For details and further investigation, click here
