| Full name: GDP-mannose 4,6-dehydratase | Alias Symbol: GMD|SDR3E1 | ||
| Type: protein-coding gene | Cytoband: 6p25.3 | ||
| Entrez ID: 2762 | HGNC ID: HGNC:4369 | Ensembl Gene: ENSG00000112699 | OMIM ID: 602884 |
| Drug and gene relationship at DGIdb | |||
Expression of GMDS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GMDS | 2762 | 204875_s_at | -0.1545 | 0.9204 | |
| GSE20347 | GMDS | 2762 | 214106_s_at | -1.6288 | 0.0000 | |
| GSE23400 | GMDS | 2762 | 214106_s_at | -0.8901 | 0.0000 | |
| GSE26886 | GMDS | 2762 | 214106_s_at | -2.2312 | 0.0000 | |
| GSE29001 | GMDS | 2762 | 214106_s_at | -2.1783 | 0.0000 | |
| GSE38129 | GMDS | 2762 | 214106_s_at | -1.3469 | 0.0000 | |
| GSE45670 | GMDS | 2762 | 214106_s_at | -1.4905 | 0.0000 | |
| GSE53622 | GMDS | 2762 | 4818 | -1.4610 | 0.0000 | |
| GSE53624 | GMDS | 2762 | 4818 | -2.2673 | 0.0000 | |
| GSE63941 | GMDS | 2762 | 204875_s_at | 1.1146 | 0.0918 | |
| GSE77861 | GMDS | 2762 | 214106_s_at | -1.3352 | 0.0007 | |
| GSE97050 | GMDS | 2762 | A_23_P72068 | -0.0167 | 0.9857 | |
| SRP007169 | GMDS | 2762 | RNAseq | -4.0865 | 0.0000 | |
| SRP008496 | GMDS | 2762 | RNAseq | -4.0655 | 0.0000 | |
| SRP064894 | GMDS | 2762 | RNAseq | -2.7207 | 0.0000 | |
| SRP133303 | GMDS | 2762 | RNAseq | -1.9030 | 0.0000 | |
| SRP159526 | GMDS | 2762 | RNAseq | -1.7026 | 0.0000 | |
| SRP193095 | GMDS | 2762 | RNAseq | -1.3599 | 0.0000 | |
| SRP219564 | GMDS | 2762 | RNAseq | -1.1169 | 0.1291 | |
| TCGA | GMDS | 2762 | RNAseq | -0.4967 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by GMDS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GMDS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GMDS | 2762 | 3 | 6 | 21 | |
| GSE20123 | GMDS | 2762 | 3 | 6 | 21 | |
| GSE43470 | GMDS | 2762 | 9 | 4 | 30 | |
| GSE46452 | GMDS | 2762 | 1 | 10 | 48 | |
| GSE47630 | GMDS | 2762 | 7 | 8 | 25 | |
| GSE54993 | GMDS | 2762 | 1 | 1 | 68 | |
| GSE54994 | GMDS | 2762 | 10 | 3 | 40 | |
| GSE60625 | GMDS | 2762 | 0 | 1 | 10 | |
| GSE74703 | GMDS | 2762 | 8 | 3 | 25 | |
| GSE74704 | GMDS | 2762 | 2 | 3 | 15 | |
| TCGA | GMDS | 2762 | 16 | 31 | 49 |
Total number of gains: 60; Total number of losses: 76; Total Number of normals: 352.
Somatic mutations of GMDS:
Generating mutation plots.
Highly correlated genes for GMDS:
Showing top 20/1460 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GMDS | ST3GAL4 | 0.819716 | 9 | 0 | 9 |
| GMDS | PRSS27 | 0.819523 | 5 | 0 | 5 |
| GMDS | CYSRT1 | 0.813534 | 5 | 0 | 5 |
| GMDS | YOD1 | 0.811893 | 10 | 0 | 10 |
| GMDS | MXD1 | 0.810505 | 9 | 0 | 9 |
| GMDS | CAPN14 | 0.809355 | 5 | 0 | 5 |
| GMDS | DUSP5 | 0.80864 | 10 | 0 | 10 |
| GMDS | GYS2 | 0.806941 | 10 | 0 | 9 |
| GMDS | SPINK7 | 0.806264 | 5 | 0 | 5 |
| GMDS | CRISP3 | 0.805655 | 10 | 0 | 9 |
| GMDS | UBL3 | 0.802448 | 10 | 0 | 9 |
| GMDS | SLURP1 | 0.800386 | 9 | 0 | 9 |
| GMDS | VSIG10L | 0.79945 | 5 | 0 | 5 |
| GMDS | AIF1L | 0.797526 | 5 | 0 | 5 |
| GMDS | ARHGAP27 | 0.795807 | 7 | 0 | 7 |
| GMDS | SCNN1B | 0.795335 | 10 | 0 | 9 |
| GMDS | CXCR2 | 0.794149 | 9 | 0 | 9 |
| GMDS | PRSS2 | 0.789439 | 7 | 0 | 7 |
| GMDS | EHD3 | 0.789426 | 11 | 0 | 10 |
| GMDS | CLIC3 | 0.788198 | 8 | 0 | 8 |
For details and further investigation, click here
