| Full name: matrix metallopeptidase 11 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q11.23 | ||
| Entrez ID: 4320 | HGNC ID: HGNC:7157 | Ensembl Gene: ENSG00000099953 | OMIM ID: 185261 |
| Drug and gene relationship at DGIdb | |||
Expression of MMP11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP11 | 4320 | 203878_s_at | 2.5593 | 0.0132 | |
| GSE20347 | MMP11 | 4320 | 203878_s_at | 1.7233 | 0.0000 | |
| GSE23400 | MMP11 | 4320 | 203878_s_at | 1.6132 | 0.0000 | |
| GSE26886 | MMP11 | 4320 | 235908_at | 0.0964 | 0.4776 | |
| GSE29001 | MMP11 | 4320 | 203878_s_at | 1.6679 | 0.0000 | |
| GSE38129 | MMP11 | 4320 | 203878_s_at | 2.4876 | 0.0000 | |
| GSE45670 | MMP11 | 4320 | 203878_s_at | 1.3389 | 0.0040 | |
| GSE53622 | MMP11 | 4320 | 144239 | 4.4367 | 0.0000 | |
| GSE53624 | MMP11 | 4320 | 144239 | 4.4523 | 0.0000 | |
| GSE63941 | MMP11 | 4320 | 203878_s_at | -0.0970 | 0.8339 | |
| GSE77861 | MMP11 | 4320 | 235908_at | -0.0854 | 0.5808 | |
| GSE97050 | MMP11 | 4320 | A_23_P57417 | 2.5810 | 0.0545 | |
| SRP007169 | MMP11 | 4320 | RNAseq | 9.6829 | 0.0000 | |
| SRP008496 | MMP11 | 4320 | RNAseq | 9.8753 | 0.0000 | |
| SRP064894 | MMP11 | 4320 | RNAseq | 6.0148 | 0.0000 | |
| SRP133303 | MMP11 | 4320 | RNAseq | 6.7584 | 0.0000 | |
| SRP159526 | MMP11 | 4320 | RNAseq | 5.8791 | 0.0000 | |
| SRP193095 | MMP11 | 4320 | RNAseq | 5.0568 | 0.0000 | |
| SRP219564 | MMP11 | 4320 | RNAseq | 5.6273 | 0.0000 | |
| TCGA | MMP11 | 4320 | RNAseq | 1.8353 | 0.0000 |
Upregulated datasets: 16; Downregulated datasets: 0.
Survival by MMP11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMP11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP11 | 4320 | 5 | 7 | 18 | |
| GSE20123 | MMP11 | 4320 | 5 | 6 | 19 | |
| GSE43470 | MMP11 | 4320 | 3 | 6 | 34 | |
| GSE46452 | MMP11 | 4320 | 32 | 1 | 26 | |
| GSE47630 | MMP11 | 4320 | 8 | 5 | 27 | |
| GSE54993 | MMP11 | 4320 | 3 | 6 | 61 | |
| GSE54994 | MMP11 | 4320 | 11 | 7 | 35 | |
| GSE60625 | MMP11 | 4320 | 5 | 0 | 6 | |
| GSE74703 | MMP11 | 4320 | 3 | 5 | 28 | |
| GSE74704 | MMP11 | 4320 | 2 | 3 | 15 | |
| TCGA | MMP11 | 4320 | 26 | 15 | 55 |
Total number of gains: 103; Total number of losses: 61; Total Number of normals: 324.
Somatic mutations of MMP11:
Generating mutation plots.
Highly correlated genes for MMP11:
Showing top 20/1083 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP11 | COL10A1 | 0.858006 | 11 | 0 | 10 |
| MMP11 | CTHRC1 | 0.856261 | 6 | 0 | 6 |
| MMP11 | ADAMTS12 | 0.827698 | 6 | 0 | 6 |
| MMP11 | SPP1 | 0.826001 | 9 | 0 | 9 |
| MMP11 | POSTN | 0.804136 | 10 | 0 | 10 |
| MMP11 | COL11A1 | 0.801842 | 10 | 0 | 9 |
| MMP11 | COL5A2 | 0.795241 | 10 | 0 | 10 |
| MMP11 | SPARC | 0.794371 | 9 | 0 | 9 |
| MMP11 | FOXD2 | 0.78456 | 3 | 0 | 3 |
| MMP11 | MMP1 | 0.78345 | 9 | 0 | 9 |
| MMP11 | XPR1 | 0.777521 | 4 | 0 | 4 |
| MMP11 | COL3A1 | 0.776772 | 10 | 0 | 10 |
| MMP11 | MFAP2 | 0.772526 | 11 | 0 | 10 |
| MMP11 | VCAN | 0.764911 | 10 | 0 | 10 |
| MMP11 | NDUFB9 | 0.763387 | 4 | 0 | 4 |
| MMP11 | SULF1 | 0.757406 | 10 | 0 | 10 |
| MMP11 | PLXNA1 | 0.757222 | 8 | 0 | 8 |
| MMP11 | CMSS1 | 0.756551 | 4 | 0 | 4 |
| MMP11 | APMAP | 0.753151 | 8 | 0 | 8 |
| MMP11 | PTDSS1 | 0.750704 | 8 | 0 | 8 |
For details and further investigation, click here
