| Full name: Kruppel like factor 3 | Alias Symbol: BKLF | ||
| Type: protein-coding gene | Cytoband: 4p14 | ||
| Entrez ID: 51274 | HGNC ID: HGNC:16516 | Ensembl Gene: ENSG00000109787 | OMIM ID: 609392 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of KLF3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLF3 | 51274 | 225133_at | -0.9023 | 0.2212 | |
| GSE20347 | KLF3 | 51274 | 219657_s_at | -0.4058 | 0.0003 | |
| GSE23400 | KLF3 | 51274 | 219657_s_at | -0.2558 | 0.0000 | |
| GSE26886 | KLF3 | 51274 | 225133_at | -1.5411 | 0.0000 | |
| GSE29001 | KLF3 | 51274 | 219657_s_at | -0.6817 | 0.0084 | |
| GSE38129 | KLF3 | 51274 | 219657_s_at | -0.2114 | 0.2100 | |
| GSE45670 | KLF3 | 51274 | 225133_at | -0.3440 | 0.0253 | |
| GSE53622 | KLF3 | 51274 | 160751 | -1.1805 | 0.0000 | |
| GSE53624 | KLF3 | 51274 | 160751 | -1.3554 | 0.0000 | |
| GSE63941 | KLF3 | 51274 | 225133_at | -0.4478 | 0.5098 | |
| GSE77861 | KLF3 | 51274 | 225133_at | -0.6765 | 0.0665 | |
| GSE97050 | KLF3 | 51274 | A_24_P414376 | -0.9892 | 0.0829 | |
| SRP007169 | KLF3 | 51274 | RNAseq | -1.1830 | 0.0041 | |
| SRP008496 | KLF3 | 51274 | RNAseq | -1.1035 | 0.0001 | |
| SRP064894 | KLF3 | 51274 | RNAseq | -1.1796 | 0.0000 | |
| SRP133303 | KLF3 | 51274 | RNAseq | -0.6256 | 0.0004 | |
| SRP159526 | KLF3 | 51274 | RNAseq | -1.0372 | 0.0012 | |
| SRP193095 | KLF3 | 51274 | RNAseq | -1.0307 | 0.0000 | |
| SRP219564 | KLF3 | 51274 | RNAseq | -1.0555 | 0.0194 | |
| TCGA | KLF3 | 51274 | RNAseq | -0.1198 | 0.0113 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by KLF3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLF3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLF3 | 51274 | 0 | 16 | 14 | |
| GSE20123 | KLF3 | 51274 | 0 | 16 | 14 | |
| GSE43470 | KLF3 | 51274 | 0 | 15 | 28 | |
| GSE46452 | KLF3 | 51274 | 1 | 36 | 22 | |
| GSE47630 | KLF3 | 51274 | 1 | 19 | 20 | |
| GSE54993 | KLF3 | 51274 | 8 | 0 | 62 | |
| GSE54994 | KLF3 | 51274 | 4 | 10 | 39 | |
| GSE60625 | KLF3 | 51274 | 0 | 0 | 11 | |
| GSE74703 | KLF3 | 51274 | 0 | 12 | 24 | |
| GSE74704 | KLF3 | 51274 | 0 | 9 | 11 | |
| TCGA | KLF3 | 51274 | 11 | 45 | 40 |
Total number of gains: 25; Total number of losses: 178; Total Number of normals: 285.
Somatic mutations of KLF3:
Generating mutation plots.
Highly correlated genes for KLF3:
Showing top 20/1708 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLF3 | CA13 | 0.821795 | 3 | 0 | 3 |
| KLF3 | MUC15 | 0.795429 | 6 | 0 | 6 |
| KLF3 | SPINK7 | 0.78972 | 6 | 0 | 6 |
| KLF3 | SLC10A5 | 0.785557 | 3 | 0 | 3 |
| KLF3 | TMPRSS11B | 0.779868 | 6 | 0 | 6 |
| KLF3 | FCHO2 | 0.778322 | 7 | 0 | 7 |
| KLF3 | GBP6 | 0.775465 | 4 | 0 | 4 |
| KLF3 | ARHGAP27 | 0.771037 | 7 | 0 | 7 |
| KLF3 | CAPN14 | 0.769578 | 6 | 0 | 6 |
| KLF3 | HDHD2 | 0.766992 | 4 | 0 | 3 |
| KLF3 | SPAG17 | 0.762407 | 4 | 0 | 4 |
| KLF3 | RAB11A | 0.761345 | 11 | 0 | 11 |
| KLF3 | SMIM5 | 0.760665 | 6 | 0 | 6 |
| KLF3 | CYSRT1 | 0.759993 | 6 | 0 | 6 |
| KLF3 | MPZL3 | 0.759425 | 7 | 0 | 7 |
| KLF3 | SERPINB11 | 0.757742 | 7 | 0 | 7 |
| KLF3 | CASC3 | 0.754899 | 3 | 0 | 3 |
| KLF3 | ZNF823 | 0.753983 | 7 | 0 | 7 |
| KLF3 | ATP6V1G1 | 0.752504 | 3 | 0 | 3 |
| KLF3 | SCEL | 0.752302 | 10 | 0 | 10 |
For details and further investigation, click here
