| Full name: small proline rich protein 1B | Alias Symbol: GADD33 | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 6699 | HGNC ID: HGNC:11260 | Ensembl Gene: ENSG00000169469 | OMIM ID: 182266 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SPRR1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPRR1B | 6699 | 205064_at | -0.4123 | 0.8436 | |
| GSE20347 | SPRR1B | 6699 | 205064_at | -1.6424 | 0.0137 | |
| GSE23400 | SPRR1B | 6699 | 205064_at | -0.9958 | 0.0001 | |
| GSE26886 | SPRR1B | 6699 | 205064_at | -3.7255 | 0.0005 | |
| GSE29001 | SPRR1B | 6699 | 205064_at | -1.6510 | 0.0638 | |
| GSE38129 | SPRR1B | 6699 | 205064_at | -0.5469 | 0.5652 | |
| GSE45670 | SPRR1B | 6699 | 205064_at | 0.6900 | 0.0001 | |
| GSE53622 | SPRR1B | 6699 | 25898 | -0.6118 | 0.1135 | |
| GSE53624 | SPRR1B | 6699 | 25898 | -1.5889 | 0.0000 | |
| GSE63941 | SPRR1B | 6699 | 205064_at | 1.6405 | 0.3644 | |
| GSE77861 | SPRR1B | 6699 | 205064_at | -0.2012 | 0.4714 | |
| GSE97050 | SPRR1B | 6699 | A_23_P159406 | 1.0563 | 0.1512 | |
| SRP007169 | SPRR1B | 6699 | RNAseq | -3.4334 | 0.0000 | |
| SRP008496 | SPRR1B | 6699 | RNAseq | -2.8175 | 0.0000 | |
| SRP064894 | SPRR1B | 6699 | RNAseq | -1.8007 | 0.0039 | |
| SRP133303 | SPRR1B | 6699 | RNAseq | -1.7553 | 0.0001 | |
| SRP159526 | SPRR1B | 6699 | RNAseq | -2.5534 | 0.0147 | |
| SRP219564 | SPRR1B | 6699 | RNAseq | -2.4247 | 0.0755 | |
| TCGA | SPRR1B | 6699 | RNAseq | 1.1287 | 0.0006 |
Upregulated datasets: 1; Downregulated datasets: 8.
Survival by SPRR1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPRR1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPRR1B | 6699 | 15 | 0 | 15 | |
| GSE20123 | SPRR1B | 6699 | 15 | 0 | 15 | |
| GSE43470 | SPRR1B | 6699 | 6 | 2 | 35 | |
| GSE46452 | SPRR1B | 6699 | 3 | 1 | 55 | |
| GSE47630 | SPRR1B | 6699 | 15 | 0 | 25 | |
| GSE54993 | SPRR1B | 6699 | 0 | 4 | 66 | |
| GSE54994 | SPRR1B | 6699 | 15 | 0 | 38 | |
| GSE60625 | SPRR1B | 6699 | 0 | 0 | 11 | |
| GSE74703 | SPRR1B | 6699 | 6 | 1 | 29 | |
| GSE74704 | SPRR1B | 6699 | 7 | 0 | 13 | |
| TCGA | SPRR1B | 6699 | 39 | 2 | 55 |
Total number of gains: 121; Total number of losses: 10; Total Number of normals: 357.
Somatic mutations of SPRR1B:
Generating mutation plots.
Highly correlated genes for SPRR1B:
Showing top 20/686 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPRR1B | SPRR2A | 0.906648 | 4 | 0 | 4 |
| SPRR1B | SPRR2D | 0.900741 | 4 | 0 | 4 |
| SPRR1B | SPRR2F | 0.895386 | 4 | 0 | 4 |
| SPRR1B | SPRR2E | 0.893461 | 4 | 0 | 4 |
| SPRR1B | SPRR1A | 0.843332 | 13 | 0 | 12 |
| SPRR1B | KRT6C | 0.789975 | 4 | 0 | 4 |
| SPRR1B | SPRR2B | 0.785603 | 4 | 0 | 4 |
| SPRR1B | S100A9 | 0.76885 | 11 | 0 | 11 |
| SPRR1B | CNFN | 0.767182 | 7 | 0 | 7 |
| SPRR1B | KRT80 | 0.750021 | 7 | 0 | 6 |
| SPRR1B | KRT6B | 0.747458 | 13 | 0 | 12 |
| SPRR1B | SERPINB13 | 0.745482 | 11 | 0 | 10 |
| SPRR1B | IL36RN | 0.743213 | 10 | 0 | 10 |
| SPRR1B | MALL | 0.741848 | 11 | 0 | 11 |
| SPRR1B | KLK8 | 0.740305 | 11 | 0 | 11 |
| SPRR1B | IL1RN | 0.737159 | 11 | 0 | 11 |
| SPRR1B | IVL | 0.736236 | 11 | 0 | 11 |
| SPRR1B | SBSN | 0.735791 | 8 | 0 | 7 |
| SPRR1B | CSTB | 0.735388 | 11 | 0 | 11 |
| SPRR1B | DSG3 | 0.734923 | 12 | 0 | 11 |
For details and further investigation, click here
