| Full name: syndecan 1 | Alias Symbol: CD138|syndecan|SYND1 | ||
| Type: protein-coding gene | Cytoband: 2p24.1 | ||
| Entrez ID: 6382 | HGNC ID: HGNC:10658 | Ensembl Gene: ENSG00000115884 | OMIM ID: 186355 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SDC1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of SDC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SDC1 | 6382 | 201287_s_at | 0.1949 | 0.8264 | |
| GSE20347 | SDC1 | 6382 | 201287_s_at | -0.5735 | 0.0022 | |
| GSE23400 | SDC1 | 6382 | 201287_s_at | -0.1109 | 0.3554 | |
| GSE26886 | SDC1 | 6382 | 201286_at | -1.0625 | 0.0000 | |
| GSE29001 | SDC1 | 6382 | 201287_s_at | -0.4538 | 0.2449 | |
| GSE38129 | SDC1 | 6382 | 201287_s_at | 0.5873 | 0.2615 | |
| GSE45670 | SDC1 | 6382 | 201286_at | 0.2294 | 0.1657 | |
| GSE53622 | SDC1 | 6382 | 38167 | -0.0669 | 0.7917 | |
| GSE53624 | SDC1 | 6382 | 38167 | -0.5102 | 0.0000 | |
| GSE63941 | SDC1 | 6382 | 201287_s_at | 2.7971 | 0.0000 | |
| GSE77861 | SDC1 | 6382 | 201287_s_at | 0.2546 | 0.3783 | |
| GSE97050 | SDC1 | 6382 | A_23_P16944 | 1.4692 | 0.1907 | |
| SRP007169 | SDC1 | 6382 | RNAseq | -1.3174 | 0.0015 | |
| SRP008496 | SDC1 | 6382 | RNAseq | -0.9676 | 0.0001 | |
| SRP064894 | SDC1 | 6382 | RNAseq | -0.3742 | 0.3362 | |
| SRP133303 | SDC1 | 6382 | RNAseq | -0.1463 | 0.4422 | |
| SRP159526 | SDC1 | 6382 | RNAseq | -0.2801 | 0.5318 | |
| SRP193095 | SDC1 | 6382 | RNAseq | -0.3040 | 0.2108 | |
| SRP219564 | SDC1 | 6382 | RNAseq | -0.5389 | 0.5996 | |
| TCGA | SDC1 | 6382 | RNAseq | 0.5590 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by SDC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SDC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SDC1 | 6382 | 10 | 2 | 18 | |
| GSE20123 | SDC1 | 6382 | 10 | 2 | 18 | |
| GSE43470 | SDC1 | 6382 | 2 | 0 | 41 | |
| GSE46452 | SDC1 | 6382 | 3 | 4 | 52 | |
| GSE47630 | SDC1 | 6382 | 7 | 0 | 33 | |
| GSE54993 | SDC1 | 6382 | 0 | 7 | 63 | |
| GSE54994 | SDC1 | 6382 | 11 | 0 | 42 | |
| GSE60625 | SDC1 | 6382 | 0 | 3 | 8 | |
| GSE74703 | SDC1 | 6382 | 2 | 0 | 34 | |
| GSE74704 | SDC1 | 6382 | 8 | 2 | 10 | |
| TCGA | SDC1 | 6382 | 36 | 2 | 58 |
Total number of gains: 89; Total number of losses: 22; Total Number of normals: 377.
Somatic mutations of SDC1:
Generating mutation plots.
Highly correlated genes for SDC1:
Showing top 20/614 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SDC1 | FAM83F | 0.735551 | 4 | 0 | 4 |
| SDC1 | LAD1 | 0.728217 | 12 | 0 | 10 |
| SDC1 | KRT6C | 0.71582 | 4 | 0 | 3 |
| SDC1 | JUP | 0.712059 | 12 | 0 | 11 |
| SDC1 | GNA15 | 0.71158 | 12 | 0 | 11 |
| SDC1 | MAL2 | 0.70943 | 6 | 0 | 5 |
| SDC1 | SLC25A39 | 0.706296 | 5 | 0 | 4 |
| SDC1 | MPZL3 | 0.705821 | 5 | 0 | 5 |
| SDC1 | DSP | 0.699048 | 11 | 0 | 10 |
| SDC1 | FAM110C | 0.698277 | 4 | 0 | 4 |
| SDC1 | FAM83C | 0.695296 | 5 | 0 | 4 |
| SDC1 | FAM160A1 | 0.694409 | 6 | 0 | 6 |
| SDC1 | ESRP1 | 0.691046 | 10 | 0 | 9 |
| SDC1 | GGCT | 0.689981 | 6 | 0 | 6 |
| SDC1 | S100A2 | 0.687164 | 9 | 0 | 8 |
| SDC1 | CDH1 | 0.685429 | 13 | 0 | 10 |
| SDC1 | GJB2 | 0.685382 | 6 | 0 | 5 |
| SDC1 | DSC3 | 0.682374 | 10 | 0 | 8 |
| SDC1 | PKP3 | 0.680922 | 10 | 0 | 10 |
| SDC1 | PRRG4 | 0.678891 | 10 | 0 | 9 |
For details and further investigation, click here
