WT1

 

Full name: WT1 transcription factor Alias Symbol: WAGR|WIT-2|AWT1|NPHS4
Type: protein-coding gene Cytoband: 11p13
Entrez ID: 7490 HGNC ID: HGNC:12796 Ensembl Gene: ENSG00000184937 OMIM ID: 607102
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of WT1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 WT1 7490 216953_s_at -0.0991 0.6928
GSE20347 WT1 7490 216953_s_at 0.0379 0.6159
GSE23400 WT1 7490 216953_s_at -0.1021 0.0163
GSE26886 WT1 7490 206067_s_at 0.6343 0.0020
GSE29001 WT1 7490 216953_s_at -0.0513 0.7380
GSE38129 WT1 7490 216953_s_at -0.0197 0.8231
GSE45670 WT1 7490 216953_s_at 0.0532 0.6981
GSE53622 WT1 7490 124668 0.9929 0.0002
GSE53624 WT1 7490 124668 2.3267 0.0000
GSE63941 WT1 7490 206067_s_at 1.5734 0.1630
GSE77861 WT1 7490 206067_s_at 0.0356 0.7908
TCGA WT1 7490 RNAseq 2.2121 0.0030

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by WT1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of WT1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 WT1 7490 1 8 21
GSE20123 WT1 7490 1 7 22
GSE43470 WT1 7490 3 4 36
GSE46452 WT1 7490 8 5 46
GSE47630 WT1 7490 3 10 27
GSE54993 WT1 7490 3 0 67
GSE54994 WT1 7490 4 10 39
GSE60625 WT1 7490 0 0 11
GSE74703 WT1 7490 3 2 31
GSE74704 WT1 7490 0 6 14
TCGA WT1 7490 12 23 61

Total number of gains: 38; Total number of losses: 75; Total Number of normals: 375.  

 

Somatic mutations of WT1:

 

Generating mutation plots.

 

Highly correlated genes for WT1:

 

Showing top 20/390 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
WT1MED240.719637404
WT1ATOH10.691558404
WT1ZNF3580.673959303
WT1GP90.672127504
WT1PALM30.660582303
WT1SLC10A10.654419505
WT1GYG20.653556303
WT1HHLA10.649803404
WT1GP20.648681504
WT1FGF30.646982303
WT1C1orf680.646403303
WT1CYP2D60.645099404
WT1GRIN10.638989505
WT1FOLR30.638439303
WT1AGER0.638037303
WT1SARDH0.636248605
WT1PRSS500.631266403
WT1EDA2R0.62585605
WT1CCR40.625586403
WT1MEPE0.621721404

For details and further investigation, click here