| Full name: integrin subunit beta 7 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 3695 | HGNC ID: HGNC:6162 | Ensembl Gene: ENSG00000139626 | OMIM ID: 147559 |
| Drug and gene relationship at DGIdb | |||
ITGB7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of ITGB7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITGB7 | 3695 | 205718_at | -0.1796 | 0.7625 | |
| GSE20347 | ITGB7 | 3695 | 205718_at | -0.2942 | 0.0020 | |
| GSE23400 | ITGB7 | 3695 | 205718_at | -0.3268 | 0.0000 | |
| GSE26886 | ITGB7 | 3695 | 205718_at | -0.5830 | 0.0004 | |
| GSE29001 | ITGB7 | 3695 | 205718_at | -0.4415 | 0.0037 | |
| GSE38129 | ITGB7 | 3695 | 205718_at | -0.2558 | 0.0406 | |
| GSE45670 | ITGB7 | 3695 | 205718_at | -0.0999 | 0.4833 | |
| GSE63941 | ITGB7 | 3695 | 205718_at | 0.6585 | 0.0005 | |
| GSE77861 | ITGB7 | 3695 | 205718_at | -0.2348 | 0.2406 | |
| GSE97050 | ITGB7 | 3695 | A_23_P76529 | 0.6065 | 0.2709 | |
| SRP007169 | ITGB7 | 3695 | RNAseq | -1.0493 | 0.0755 | |
| SRP064894 | ITGB7 | 3695 | RNAseq | -0.7283 | 0.0007 | |
| SRP133303 | ITGB7 | 3695 | RNAseq | -0.5928 | 0.1019 | |
| SRP159526 | ITGB7 | 3695 | RNAseq | -1.3098 | 0.0865 | |
| SRP193095 | ITGB7 | 3695 | RNAseq | -0.7708 | 0.0001 | |
| SRP219564 | ITGB7 | 3695 | RNAseq | -0.0745 | 0.9324 | |
| TCGA | ITGB7 | 3695 | RNAseq | 0.1033 | 0.5227 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ITGB7 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ITGB7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITGB7 | 3695 | 8 | 1 | 21 | |
| GSE20123 | ITGB7 | 3695 | 8 | 1 | 21 | |
| GSE43470 | ITGB7 | 3695 | 3 | 0 | 40 | |
| GSE46452 | ITGB7 | 3695 | 7 | 1 | 51 | |
| GSE47630 | ITGB7 | 3695 | 10 | 2 | 28 | |
| GSE54993 | ITGB7 | 3695 | 0 | 5 | 65 | |
| GSE54994 | ITGB7 | 3695 | 4 | 1 | 48 | |
| GSE60625 | ITGB7 | 3695 | 0 | 0 | 11 | |
| GSE74703 | ITGB7 | 3695 | 3 | 0 | 33 | |
| GSE74704 | ITGB7 | 3695 | 5 | 1 | 14 | |
| TCGA | ITGB7 | 3695 | 13 | 11 | 72 |
Total number of gains: 61; Total number of losses: 23; Total Number of normals: 404.
Somatic mutations of ITGB7:
Generating mutation plots.
Highly correlated genes for ITGB7:
Showing top 20/866 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITGB7 | AP1G2 | 0.700752 | 3 | 0 | 3 |
| ITGB7 | ST7-AS2 | 0.695586 | 3 | 0 | 3 |
| ITGB7 | DMKN | 0.681954 | 4 | 0 | 4 |
| ITGB7 | PRRG2 | 0.669582 | 6 | 0 | 6 |
| ITGB7 | APOA4 | 0.669094 | 5 | 0 | 5 |
| ITGB7 | IRX3 | 0.667707 | 3 | 0 | 3 |
| ITGB7 | MYCL | 0.666383 | 3 | 0 | 3 |
| ITGB7 | PRDM12 | 0.663292 | 5 | 0 | 4 |
| ITGB7 | NFYC | 0.661196 | 4 | 0 | 4 |
| ITGB7 | LINC01215 | 0.659906 | 3 | 0 | 3 |
| ITGB7 | TESC | 0.659854 | 3 | 0 | 3 |
| ITGB7 | POU2F2 | 0.656897 | 7 | 0 | 6 |
| ITGB7 | RECQL5 | 0.655511 | 9 | 0 | 7 |
| ITGB7 | TMEM45B | 0.654493 | 3 | 0 | 3 |
| ITGB7 | TYSND1 | 0.653984 | 3 | 0 | 3 |
| ITGB7 | ZNF296 | 0.653701 | 5 | 0 | 4 |
| ITGB7 | ARHGAP4 | 0.65144 | 3 | 0 | 3 |
| ITGB7 | LLGL2 | 0.648785 | 9 | 0 | 8 |
| ITGB7 | UBE2D2 | 0.648742 | 3 | 0 | 3 |
| ITGB7 | PARVG | 0.645661 | 3 | 0 | 3 |
For details and further investigation, click here
