MCM5

 

Full name: minichromosome maintenance complex component 5 Alias Symbol: 
Type: protein-coding gene Cytoband: 22q12.3
Entrez ID: 4174 HGNC ID: HGNC:6948 Ensembl Gene: ENSG00000100297 OMIM ID: 602696
Drug and gene relationship at DGIdb

 

MCM5 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle

 

Expression of MCM5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MCM5 4174 216237_s_at 1.1854 0.0305
GSE20347 MCM5 4174 216237_s_at 1.0014 0.0000
GSE23400 MCM5 4174 216237_s_at 1.3015 0.0000
GSE26886 MCM5 4174 216237_s_at 1.1562 0.0005
GSE29001 MCM5 4174 216237_s_at 1.2524 0.0004
GSE38129 MCM5 4174 216237_s_at 1.1821 0.0000
GSE45670 MCM5 4174 216237_s_at 0.8356 0.0001
GSE53622 MCM5 4174 90680 1.2560 0.0000
GSE53624 MCM5 4174 78715 0.3152 0.0000
GSE63941 MCM5 4174 216237_s_at 2.9175 0.0002
GSE77861 MCM5 4174 216237_s_at 1.1456 0.0060
GSE97050 MCM5 4174 A_23_P132277 1.0373 0.1403
SRP007169 MCM5 4174 RNAseq 1.6078 0.0016
SRP008496 MCM5 4174 RNAseq 1.0998 0.0014
SRP064894 MCM5 4174 RNAseq 1.7255 0.0000
SRP133303 MCM5 4174 RNAseq 0.9696 0.0000
SRP159526 MCM5 4174 RNAseq 1.3354 0.0001
SRP193095 MCM5 4174 RNAseq 1.0272 0.0000
SRP219564 MCM5 4174 RNAseq 1.6503 0.0006
TCGA MCM5 4174 RNAseq 0.5588 0.0000

Upregulated datasets: 15; Downregulated datasets: 0.  

 

Survival by MCM5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MCM5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MCM5 4174 4 6 20
GSE20123 MCM5 4174 4 5 21
GSE43470 MCM5 4174 4 7 32
GSE46452 MCM5 4174 31 1 27
GSE47630 MCM5 4174 8 5 27
GSE54993 MCM5 4174 3 6 61
GSE54994 MCM5 4174 9 9 35
GSE60625 MCM5 4174 5 0 6
GSE74703 MCM5 4174 4 5 27
GSE74704 MCM5 4174 1 2 17
TCGA MCM5 4174 27 15 54

Total number of gains: 100; Total number of losses: 61; Total Number of normals: 327.  

 

Somatic mutations of MCM5:

 

Generating mutation plots.

 

Highly correlated genes for MCM5:

 

Showing top 20/1594 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MCM5MCM20.85120812012
MCM5GINS20.83820811011
MCM5CDC450.82789511011
MCM5TK10.80867812012
MCM5RAD51AP10.80664311011
MCM5BUB1B0.80640810010
MCM5NCAPH0.803009909
MCM5ZNF3170.799743303
MCM5KIF18B0.79460211011
MCM5BUB10.79397808
MCM5KIF2C0.79151211011
MCM5CDCA30.78881610010
MCM5TIMELESS0.78789111011
MCM5FOXM10.78737312011
MCM5FEN10.78676711011
MCM5MYBL20.78424212011
MCM5GINS10.78216610010
MCM5NUSAP10.78021810010
MCM5CENPF0.77766411011
MCM5CENPM0.77652312010

For details and further investigation, click here