| Full name: zona pellucida like domain containing 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q12.3 | ||
| Entrez ID: 131368 | HGNC ID: HGNC:27022 | Ensembl Gene: ENSG00000170044 | OMIM ID: 615915 |
| Drug and gene relationship at DGIdb | |||
Expression of ZPLD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZPLD1 | 131368 | 1561969_at | 0.1762 | 0.3586 | |
| GSE26886 | ZPLD1 | 131368 | 1561969_at | 0.2333 | 0.1278 | |
| GSE45670 | ZPLD1 | 131368 | 1569777_a_at | 0.1488 | 0.0637 | |
| GSE53622 | ZPLD1 | 131368 | 18472 | 1.3943 | 0.0000 | |
| GSE53624 | ZPLD1 | 131368 | 18472 | 1.7830 | 0.0000 | |
| GSE63941 | ZPLD1 | 131368 | 1561969_at | 0.1109 | 0.9238 | |
| GSE77861 | ZPLD1 | 131368 | 1561969_at | 0.0026 | 0.9777 | |
| TCGA | ZPLD1 | 131368 | RNAseq | 2.3681 | 0.0001 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by ZPLD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZPLD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZPLD1 | 131368 | 18 | 1 | 11 | |
| GSE20123 | ZPLD1 | 131368 | 17 | 1 | 12 | |
| GSE43470 | ZPLD1 | 131368 | 17 | 1 | 25 | |
| GSE46452 | ZPLD1 | 131368 | 12 | 6 | 41 | |
| GSE47630 | ZPLD1 | 131368 | 16 | 6 | 18 | |
| GSE54993 | ZPLD1 | 131368 | 2 | 5 | 63 | |
| GSE54994 | ZPLD1 | 131368 | 27 | 5 | 21 | |
| GSE60625 | ZPLD1 | 131368 | 0 | 6 | 5 | |
| GSE74703 | ZPLD1 | 131368 | 14 | 1 | 21 | |
| GSE74704 | ZPLD1 | 131368 | 14 | 1 | 5 | |
| TCGA | ZPLD1 | 131368 | 48 | 10 | 38 |
Total number of gains: 185; Total number of losses: 43; Total Number of normals: 260.
Somatic mutations of ZPLD1:
Generating mutation plots.
Highly correlated genes for ZPLD1:
Showing top 20/29 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZPLD1 | KIF26B | 0.629579 | 3 | 0 | 3 |
| ZPLD1 | COL5A2 | 0.603502 | 3 | 0 | 3 |
| ZPLD1 | RNF2 | 0.593877 | 3 | 0 | 3 |
| ZPLD1 | COL5A1 | 0.592865 | 3 | 0 | 3 |
| ZPLD1 | INHBA | 0.581292 | 3 | 0 | 3 |
| ZPLD1 | MFAP2 | 0.580563 | 3 | 0 | 3 |
| ZPLD1 | C11orf65 | 0.571253 | 3 | 0 | 3 |
| ZPLD1 | LAMP5 | 0.565005 | 4 | 0 | 3 |
| ZPLD1 | DCSTAMP | 0.564659 | 3 | 0 | 3 |
| ZPLD1 | MMD | 0.562053 | 3 | 0 | 3 |
| ZPLD1 | LAMC2 | 0.561659 | 3 | 0 | 3 |
| ZPLD1 | SHC1 | 0.560814 | 3 | 0 | 3 |
| ZPLD1 | WNT2 | 0.556497 | 4 | 0 | 3 |
| ZPLD1 | PANX1 | 0.553491 | 3 | 0 | 3 |
| ZPLD1 | MASTL | 0.552421 | 4 | 0 | 3 |
| ZPLD1 | BGN | 0.551524 | 3 | 0 | 3 |
| ZPLD1 | NEDD1 | 0.550804 | 4 | 0 | 3 |
| ZPLD1 | ZNF281 | 0.548179 | 4 | 0 | 3 |
| ZPLD1 | ZNF469 | 0.547019 | 3 | 0 | 3 |
| ZPLD1 | ZNFX1 | 0.535637 | 4 | 0 | 4 |
For details and further investigation, click here
