| Full name: ATP binding cassette subfamily B member 8 | Alias Symbol: EST328128|M-ABC1|MABC1 | ||
| Type: protein-coding gene | Cytoband: 7q36.1 | ||
| Entrez ID: 11194 | HGNC ID: HGNC:49 | Ensembl Gene: ENSG00000197150 | OMIM ID: 605464 |
| Drug and gene relationship at DGIdb | |||
Expression of ABCB8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABCB8 | 11194 | 229539_at | 0.2563 | 0.2917 | |
| GSE20347 | ABCB8 | 11194 | 206317_s_at | -0.1534 | 0.1086 | |
| GSE23400 | ABCB8 | 11194 | 206317_s_at | -0.0840 | 0.0244 | |
| GSE26886 | ABCB8 | 11194 | 229539_at | -0.0571 | 0.7347 | |
| GSE29001 | ABCB8 | 11194 | 206317_s_at | -0.0996 | 0.5157 | |
| GSE38129 | ABCB8 | 11194 | 206317_s_at | -0.1077 | 0.2279 | |
| GSE45670 | ABCB8 | 11194 | 229539_at | 0.2395 | 0.0146 | |
| GSE53622 | ABCB8 | 11194 | 41057 | -0.2650 | 0.0109 | |
| GSE53624 | ABCB8 | 11194 | 41057 | -0.1608 | 0.0274 | |
| GSE63941 | ABCB8 | 11194 | 229539_at | -0.7151 | 0.0027 | |
| GSE77861 | ABCB8 | 11194 | 229539_at | -0.0125 | 0.9314 | |
| GSE97050 | ABCB8 | 11194 | A_23_P82249 | 0.1368 | 0.4983 | |
| SRP007169 | ABCB8 | 11194 | RNAseq | -0.6889 | 0.1691 | |
| SRP008496 | ABCB8 | 11194 | RNAseq | -1.0406 | 0.0018 | |
| SRP064894 | ABCB8 | 11194 | RNAseq | 0.3221 | 0.1441 | |
| SRP133303 | ABCB8 | 11194 | RNAseq | -0.2061 | 0.2312 | |
| SRP159526 | ABCB8 | 11194 | RNAseq | -0.1639 | 0.4179 | |
| SRP193095 | ABCB8 | 11194 | RNAseq | -0.1199 | 0.2945 | |
| SRP219564 | ABCB8 | 11194 | RNAseq | 0.4151 | 0.2560 | |
| TCGA | ABCB8 | 11194 | RNAseq | -0.0441 | 0.4015 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ABCB8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABCB8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABCB8 | 11194 | 2 | 4 | 24 | |
| GSE20123 | ABCB8 | 11194 | 2 | 4 | 24 | |
| GSE43470 | ABCB8 | 11194 | 2 | 5 | 36 | |
| GSE46452 | ABCB8 | 11194 | 7 | 2 | 50 | |
| GSE47630 | ABCB8 | 11194 | 5 | 9 | 26 | |
| GSE54993 | ABCB8 | 11194 | 3 | 3 | 64 | |
| GSE54994 | ABCB8 | 11194 | 5 | 8 | 40 | |
| GSE60625 | ABCB8 | 11194 | 0 | 0 | 11 | |
| GSE74703 | ABCB8 | 11194 | 2 | 4 | 30 | |
| GSE74704 | ABCB8 | 11194 | 1 | 4 | 15 | |
| TCGA | ABCB8 | 11194 | 26 | 25 | 45 |
Total number of gains: 55; Total number of losses: 68; Total Number of normals: 365.
Somatic mutations of ABCB8:
Generating mutation plots.
Highly correlated genes for ABCB8:
Showing top 20/84 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABCB8 | C19orf18 | 0.698928 | 3 | 0 | 3 |
| ABCB8 | HBD | 0.664676 | 3 | 0 | 3 |
| ABCB8 | IP6K1 | 0.647065 | 4 | 0 | 3 |
| ABCB8 | ADAM21 | 0.647056 | 3 | 0 | 3 |
| ABCB8 | PTPN23 | 0.642261 | 3 | 0 | 3 |
| ABCB8 | KLHL18 | 0.637152 | 3 | 0 | 3 |
| ABCB8 | CCDC170 | 0.636101 | 3 | 0 | 3 |
| ABCB8 | FZR1 | 0.634269 | 5 | 0 | 4 |
| ABCB8 | KIAA0513 | 0.628451 | 3 | 0 | 3 |
| ABCB8 | CTIF | 0.62706 | 3 | 0 | 3 |
| ABCB8 | SNPH | 0.621401 | 3 | 0 | 3 |
| ABCB8 | HDAC7 | 0.614173 | 4 | 0 | 3 |
| ABCB8 | TBX6 | 0.610264 | 3 | 0 | 3 |
| ABCB8 | MPV17L2 | 0.607079 | 3 | 0 | 3 |
| ABCB8 | ATF6B | 0.606277 | 4 | 0 | 3 |
| ABCB8 | POLL | 0.597584 | 3 | 0 | 3 |
| ABCB8 | PRSS53 | 0.590735 | 3 | 0 | 3 |
| ABCB8 | MAPK8IP3 | 0.588876 | 3 | 0 | 3 |
| ABCB8 | LIMD1 | 0.588587 | 3 | 0 | 3 |
| ABCB8 | SPTB | 0.585831 | 4 | 0 | 4 |
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