| Full name: serine protease 53 | Alias Symbol: POL3S | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 339105 | HGNC ID: HGNC:34407 | Ensembl Gene: ENSG00000151006 | OMIM ID: 610561 |
| Drug and gene relationship at DGIdb | |||
Expression of PRSS53:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRSS53 | 339105 | 214226_at | 0.1635 | 0.4751 | |
| GSE20347 | PRSS53 | 339105 | 214226_at | 0.0050 | 0.9670 | |
| GSE23400 | PRSS53 | 339105 | 214226_at | 0.0895 | 0.1072 | |
| GSE26886 | PRSS53 | 339105 | 214226_at | 0.0583 | 0.7280 | |
| GSE29001 | PRSS53 | 339105 | 214226_at | -0.0992 | 0.7115 | |
| GSE38129 | PRSS53 | 339105 | 214226_at | -0.0525 | 0.5470 | |
| GSE45670 | PRSS53 | 339105 | 214226_at | 0.2898 | 0.0202 | |
| GSE63941 | PRSS53 | 339105 | 214226_at | -0.0591 | 0.7818 | |
| GSE77861 | PRSS53 | 339105 | 214226_at | 0.1735 | 0.1990 | |
| GSE97050 | PRSS53 | 339105 | A_33_P3340565 | 0.1400 | 0.4989 | |
| SRP064894 | PRSS53 | 339105 | RNAseq | 1.1349 | 0.0000 | |
| SRP133303 | PRSS53 | 339105 | RNAseq | 0.7078 | 0.0016 | |
| SRP159526 | PRSS53 | 339105 | RNAseq | 1.1988 | 0.0908 | |
| SRP193095 | PRSS53 | 339105 | RNAseq | 0.9035 | 0.0000 | |
| SRP219564 | PRSS53 | 339105 | RNAseq | 0.4348 | 0.2126 | |
| TCGA | PRSS53 | 339105 | RNAseq | 0.4518 | 0.0031 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PRSS53 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PRSS53:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRSS53 | 339105 | 5 | 5 | 20 | |
| GSE20123 | PRSS53 | 339105 | 5 | 4 | 21 | |
| GSE43470 | PRSS53 | 339105 | 3 | 3 | 37 | |
| GSE46452 | PRSS53 | 339105 | 38 | 1 | 20 | |
| GSE47630 | PRSS53 | 339105 | 11 | 7 | 22 | |
| GSE54993 | PRSS53 | 339105 | 2 | 5 | 63 | |
| GSE54994 | PRSS53 | 339105 | 5 | 9 | 39 | |
| GSE60625 | PRSS53 | 339105 | 4 | 0 | 7 | |
| GSE74703 | PRSS53 | 339105 | 3 | 2 | 31 | |
| GSE74704 | PRSS53 | 339105 | 3 | 2 | 15 | |
| TCGA | PRSS53 | 339105 | 20 | 10 | 66 |
Total number of gains: 99; Total number of losses: 48; Total Number of normals: 341.
Somatic mutations of PRSS53:
Generating mutation plots.
Highly correlated genes for PRSS53:
Showing top 20/403 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRSS53 | BMF | 0.698664 | 3 | 0 | 3 |
| PRSS53 | GPSM3 | 0.695148 | 3 | 0 | 3 |
| PRSS53 | IGFLR1 | 0.686728 | 3 | 0 | 3 |
| PRSS53 | NEUROD4 | 0.686686 | 4 | 0 | 4 |
| PRSS53 | RHBDF2 | 0.681923 | 3 | 0 | 3 |
| PRSS53 | AIP | 0.681399 | 3 | 0 | 3 |
| PRSS53 | ABCC2 | 0.681363 | 4 | 0 | 4 |
| PRSS53 | FAM160B2 | 0.679739 | 5 | 0 | 5 |
| PRSS53 | VENTX | 0.675453 | 3 | 0 | 3 |
| PRSS53 | PRODH2 | 0.675186 | 5 | 0 | 5 |
| PRSS53 | GPD1 | 0.674259 | 3 | 0 | 3 |
| PRSS53 | CLCN6 | 0.666526 | 3 | 0 | 3 |
| PRSS53 | HCRTR1 | 0.666461 | 5 | 0 | 4 |
| PRSS53 | CA9 | 0.665687 | 3 | 0 | 3 |
| PRSS53 | CD320 | 0.665053 | 4 | 0 | 3 |
| PRSS53 | IQCA1 | 0.662956 | 3 | 0 | 3 |
| PRSS53 | MAS1 | 0.656217 | 4 | 0 | 3 |
| PRSS53 | PRKAR1B | 0.653619 | 3 | 0 | 3 |
| PRSS53 | ARVCF | 0.653307 | 8 | 0 | 7 |
| PRSS53 | KCNJ13 | 0.653275 | 3 | 0 | 3 |
For details and further investigation, click here
