| Full name: spindle and kinetochore associated complex subunit 2 | Alias Symbol: FLJ12758 | ||
| Type: protein-coding gene | Cytoband: 17q23.2 | ||
| Entrez ID: 348235 | HGNC ID: HGNC:28006 | Ensembl Gene: ENSG00000182628 | OMIM ID: 616674 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SKA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SKA2 | 348235 | 225684_at | 0.1250 | 0.7944 | |
| GSE26886 | SKA2 | 348235 | 225684_at | 0.1384 | 0.6822 | |
| GSE45670 | SKA2 | 348235 | 225684_at | 0.0646 | 0.7351 | |
| GSE53622 | SKA2 | 348235 | 2788 | 0.2854 | 0.0000 | |
| GSE53624 | SKA2 | 348235 | 38861 | 0.4574 | 0.0000 | |
| GSE63941 | SKA2 | 348235 | 225684_at | 0.9547 | 0.0294 | |
| GSE77861 | SKA2 | 348235 | 225684_at | 0.0971 | 0.8027 | |
| GSE97050 | SKA2 | 348235 | A_32_P55860 | -0.0258 | 0.9425 | |
| SRP007169 | SKA2 | 348235 | RNAseq | -0.1950 | 0.5945 | |
| SRP008496 | SKA2 | 348235 | RNAseq | -0.1365 | 0.5990 | |
| SRP064894 | SKA2 | 348235 | RNAseq | 0.4886 | 0.0136 | |
| SRP133303 | SKA2 | 348235 | RNAseq | 0.8204 | 0.0006 | |
| SRP159526 | SKA2 | 348235 | RNAseq | 0.7280 | 0.0434 | |
| SRP193095 | SKA2 | 348235 | RNAseq | 0.0873 | 0.5276 | |
| SRP219564 | SKA2 | 348235 | RNAseq | 0.1592 | 0.6371 | |
| TCGA | SKA2 | 348235 | RNAseq | 0.2890 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SKA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SKA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SKA2 | 348235 | 6 | 1 | 23 | |
| GSE20123 | SKA2 | 348235 | 6 | 1 | 23 | |
| GSE43470 | SKA2 | 348235 | 3 | 0 | 40 | |
| GSE46452 | SKA2 | 348235 | 32 | 0 | 27 | |
| GSE47630 | SKA2 | 348235 | 7 | 1 | 32 | |
| GSE54993 | SKA2 | 348235 | 2 | 5 | 63 | |
| GSE54994 | SKA2 | 348235 | 9 | 5 | 39 | |
| GSE60625 | SKA2 | 348235 | 4 | 0 | 7 | |
| GSE74703 | SKA2 | 348235 | 3 | 0 | 33 | |
| GSE74704 | SKA2 | 348235 | 5 | 1 | 14 | |
| TCGA | SKA2 | 348235 | 26 | 7 | 63 |
Total number of gains: 103; Total number of losses: 21; Total Number of normals: 364.
Somatic mutations of SKA2:
Generating mutation plots.
Highly correlated genes for SKA2:
Showing top 20/213 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SKA2 | GNAI1 | 0.7431 | 3 | 0 | 3 |
| SKA2 | PAAF1 | 0.732964 | 3 | 0 | 3 |
| SKA2 | PPP1R21 | 0.726004 | 3 | 0 | 3 |
| SKA2 | ELP3 | 0.709419 | 3 | 0 | 3 |
| SKA2 | CORO1C | 0.706338 | 3 | 0 | 3 |
| SKA2 | RPS6KB1 | 0.70324 | 3 | 0 | 3 |
| SKA2 | EPAS1 | 0.701405 | 3 | 0 | 3 |
| SKA2 | JDP2 | 0.70123 | 3 | 0 | 3 |
| SKA2 | ACER3 | 0.701153 | 3 | 0 | 3 |
| SKA2 | SNRPA | 0.69001 | 4 | 0 | 4 |
| SKA2 | MRPL17 | 0.679263 | 3 | 0 | 3 |
| SKA2 | C17orf67 | 0.67691 | 3 | 0 | 3 |
| SKA2 | RTN4R | 0.674495 | 3 | 0 | 3 |
| SKA2 | BORA | 0.673241 | 4 | 0 | 4 |
| SKA2 | CLSPN | 0.667846 | 4 | 0 | 4 |
| SKA2 | PTPMT1 | 0.666762 | 3 | 0 | 3 |
| SKA2 | GPSM2 | 0.664894 | 4 | 0 | 3 |
| SKA2 | SUPT7L | 0.661413 | 5 | 0 | 3 |
| SKA2 | MICALCL | 0.659345 | 3 | 0 | 3 |
| SKA2 | RAB30 | 0.656916 | 3 | 0 | 3 |
For details and further investigation, click here
