| Full name: sperm antigen with calponin homology and coiled-coil domains 1 | Alias Symbol: HCMOGT-1|FLJ36955|NSP | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 92521 | HGNC ID: HGNC:30615 | Ensembl Gene: ENSG00000128487 | OMIM ID: 608793 |
| Drug and gene relationship at DGIdb | |||
Expression of SPECC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPECC1 | 92521 | 228900_at | 0.0536 | 0.9394 | |
| GSE26886 | SPECC1 | 92521 | 223498_at | -0.2436 | 0.2049 | |
| GSE45670 | SPECC1 | 92521 | 228900_at | -0.0895 | 0.7500 | |
| GSE53622 | SPECC1 | 92521 | 126404 | -0.0190 | 0.8981 | |
| GSE53624 | SPECC1 | 92521 | 126404 | -0.1938 | 0.0478 | |
| GSE63941 | SPECC1 | 92521 | 228900_at | -0.2285 | 0.7635 | |
| GSE77861 | SPECC1 | 92521 | 228900_at | -0.0148 | 0.9202 | |
| GSE97050 | SPECC1 | 92521 | A_24_P943095 | 0.0018 | 0.9975 | |
| SRP007169 | SPECC1 | 92521 | RNAseq | -1.1625 | 0.0942 | |
| SRP008496 | SPECC1 | 92521 | RNAseq | -0.9932 | 0.0072 | |
| SRP064894 | SPECC1 | 92521 | RNAseq | -0.5884 | 0.0429 | |
| SRP133303 | SPECC1 | 92521 | RNAseq | 0.2978 | 0.1276 | |
| SRP159526 | SPECC1 | 92521 | RNAseq | -0.7822 | 0.0001 | |
| SRP193095 | SPECC1 | 92521 | RNAseq | -0.3200 | 0.0660 | |
| SRP219564 | SPECC1 | 92521 | RNAseq | -0.1920 | 0.7217 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPECC1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SPECC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPECC1 | 92521 | 4 | 3 | 23 | |
| GSE20123 | SPECC1 | 92521 | 4 | 4 | 22 | |
| GSE43470 | SPECC1 | 92521 | 1 | 5 | 37 | |
| GSE46452 | SPECC1 | 92521 | 34 | 1 | 24 | |
| GSE47630 | SPECC1 | 92521 | 7 | 1 | 32 | |
| GSE54993 | SPECC1 | 92521 | 3 | 3 | 64 | |
| GSE54994 | SPECC1 | 92521 | 6 | 6 | 41 | |
| GSE60625 | SPECC1 | 92521 | 4 | 0 | 7 | |
| GSE74703 | SPECC1 | 92521 | 1 | 2 | 33 | |
| GSE74704 | SPECC1 | 92521 | 2 | 1 | 17 | |
| TCGA | SPECC1 | 92521 | 18 | 25 | 53 |
Total number of gains: 84; Total number of losses: 51; Total Number of normals: 353.
Somatic mutations of SPECC1:
Generating mutation plots.
Highly correlated genes for SPECC1:
Showing top 20/78 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPECC1 | ACER3 | 0.741122 | 3 | 0 | 3 |
| SPECC1 | KLF7 | 0.715237 | 3 | 0 | 3 |
| SPECC1 | CDH13 | 0.713059 | 3 | 0 | 3 |
| SPECC1 | LIMA1 | 0.702829 | 4 | 0 | 4 |
| SPECC1 | TGFB2 | 0.702017 | 4 | 0 | 4 |
| SPECC1 | RBMS2 | 0.694815 | 4 | 0 | 4 |
| SPECC1 | ANXA5 | 0.692406 | 3 | 0 | 3 |
| SPECC1 | DNTTIP2 | 0.687192 | 3 | 0 | 3 |
| SPECC1 | EFNB2 | 0.68384 | 3 | 0 | 3 |
| SPECC1 | TNP2 | 0.679468 | 3 | 0 | 3 |
| SPECC1 | AMIGO2 | 0.678629 | 4 | 0 | 3 |
| SPECC1 | CAV1 | 0.672564 | 3 | 0 | 3 |
| SPECC1 | PCSK5 | 0.668602 | 3 | 0 | 3 |
| SPECC1 | DUSP6 | 0.665336 | 3 | 0 | 3 |
| SPECC1 | RPE | 0.662529 | 3 | 0 | 3 |
| SPECC1 | KCNJ15 | 0.658565 | 3 | 0 | 3 |
| SPECC1 | ALDH1A3 | 0.658 | 3 | 0 | 3 |
| SPECC1 | EGFR | 0.652901 | 3 | 0 | 3 |
| SPECC1 | RPF1 | 0.651244 | 3 | 0 | 3 |
| SPECC1 | ESR2 | 0.648344 | 3 | 0 | 3 |
For details and further investigation, click here
