| Full name: acyl-CoA oxidase 2 | Alias Symbol: BRCACOX|BRCOX|THCCox | ||
| Type: protein-coding gene | Cytoband: 3p14.3 | ||
| Entrez ID: 8309 | HGNC ID: HGNC:120 | Ensembl Gene: ENSG00000168306 | OMIM ID: 601641 |
| Drug and gene relationship at DGIdb | |||
ACOX2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway |
Expression of ACOX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACOX2 | 8309 | 205364_at | -1.3951 | 0.0285 | |
| GSE20347 | ACOX2 | 8309 | 205364_at | -0.8642 | 0.0000 | |
| GSE23400 | ACOX2 | 8309 | 205364_at | -0.4410 | 0.0000 | |
| GSE26886 | ACOX2 | 8309 | 205364_at | -0.4462 | 0.0165 | |
| GSE29001 | ACOX2 | 8309 | 205364_at | -0.8494 | 0.0003 | |
| GSE38129 | ACOX2 | 8309 | 205364_at | -1.2223 | 0.0000 | |
| GSE45670 | ACOX2 | 8309 | 205364_at | -1.7449 | 0.0000 | |
| GSE53622 | ACOX2 | 8309 | 33657 | -1.1503 | 0.0000 | |
| GSE53624 | ACOX2 | 8309 | 33657 | -1.4597 | 0.0000 | |
| GSE63941 | ACOX2 | 8309 | 205364_at | -2.5657 | 0.0004 | |
| GSE77861 | ACOX2 | 8309 | 205364_at | -0.6259 | 0.0007 | |
| GSE97050 | ACOX2 | 8309 | A_23_P10182 | -0.5466 | 0.2684 | |
| SRP064894 | ACOX2 | 8309 | RNAseq | -1.3602 | 0.0001 | |
| SRP133303 | ACOX2 | 8309 | RNAseq | -1.7602 | 0.0000 | |
| SRP159526 | ACOX2 | 8309 | RNAseq | -2.1203 | 0.0001 | |
| SRP193095 | ACOX2 | 8309 | RNAseq | -1.6780 | 0.0000 | |
| SRP219564 | ACOX2 | 8309 | RNAseq | -1.1348 | 0.2241 | |
| TCGA | ACOX2 | 8309 | RNAseq | -1.0579 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by ACOX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACOX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACOX2 | 8309 | 0 | 17 | 13 | |
| GSE20123 | ACOX2 | 8309 | 0 | 18 | 12 | |
| GSE43470 | ACOX2 | 8309 | 0 | 17 | 26 | |
| GSE46452 | ACOX2 | 8309 | 2 | 17 | 40 | |
| GSE47630 | ACOX2 | 8309 | 1 | 24 | 15 | |
| GSE54993 | ACOX2 | 8309 | 6 | 2 | 62 | |
| GSE54994 | ACOX2 | 8309 | 0 | 32 | 21 | |
| GSE60625 | ACOX2 | 8309 | 5 | 0 | 6 | |
| GSE74703 | ACOX2 | 8309 | 0 | 14 | 22 | |
| GSE74704 | ACOX2 | 8309 | 0 | 11 | 9 | |
| TCGA | ACOX2 | 8309 | 0 | 79 | 17 |
Total number of gains: 14; Total number of losses: 231; Total Number of normals: 243.
Somatic mutations of ACOX2:
Generating mutation plots.
Highly correlated genes for ACOX2:
Showing top 20/1544 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACOX2 | NEGR1 | 0.830635 | 6 | 0 | 6 |
| ACOX2 | CYP21A2 | 0.823385 | 3 | 0 | 3 |
| ACOX2 | FXYD1 | 0.810614 | 6 | 0 | 6 |
| ACOX2 | SORCS1 | 0.807571 | 4 | 0 | 4 |
| ACOX2 | RBFOX3 | 0.805899 | 3 | 0 | 3 |
| ACOX2 | CLEC3B | 0.789453 | 3 | 0 | 3 |
| ACOX2 | ABCA8 | 0.782536 | 10 | 0 | 10 |
| ACOX2 | XKR4 | 0.778022 | 5 | 0 | 5 |
| ACOX2 | MRVI1 | 0.776395 | 6 | 0 | 6 |
| ACOX2 | LINC01082 | 0.771516 | 5 | 0 | 5 |
| ACOX2 | GFRA1 | 0.767149 | 6 | 0 | 6 |
| ACOX2 | SCN7A | 0.767005 | 8 | 0 | 8 |
| ACOX2 | PHYHD1 | 0.758878 | 6 | 0 | 6 |
| ACOX2 | CDH19 | 0.757982 | 8 | 0 | 8 |
| ACOX2 | VIT | 0.75685 | 6 | 0 | 6 |
| ACOX2 | CCDC69 | 0.752418 | 12 | 0 | 11 |
| ACOX2 | KLHDC8B | 0.752225 | 5 | 0 | 5 |
| ACOX2 | RCAN2 | 0.750726 | 10 | 0 | 9 |
| ACOX2 | MAGI2-AS3 | 0.750049 | 5 | 0 | 5 |
| ACOX2 | SMDT1 | 0.749121 | 3 | 0 | 3 |
For details and further investigation, click here
