Full name: actin beta	Alias Symbol:
Type: protein-coding gene	Cytoband: 7p22.1
Entrez ID: 60	HGNC ID: HGNC:132	Ensembl Gene: ENSG00000075624	OMIM ID: 102630
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 153/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

---

 

ACTB involved pathways:

KEGG pathway	Description	View
hsa04015	Rap1 signaling pathway	View
hsa04210	Apoptosis	View
hsa04390	Hippo signaling pathway	View
hsa04510	Focal adhesion	View
hsa04520	Adherens junction	View
hsa04530	Tight junction	View
hsa04611	Platelet activation	View
hsa04670	Leukocyte transendothelial migration	View
hsa04810	Regulation of actin cytoskeleton	View
hsa04919	Thyroid hormone signaling pathway	View
hsa04921	Oxytocin signaling pathway	View
hsa04971	Gastric acid secretion	View
hsa05100	Bacterial invasion of epithelial cells	View
hsa05110	Vibrio cholerae infection	View
hsa05130	Pathogenic Escherichia coli infection	View
hsa05132	Salmonella infection	View
hsa05205	Proteoglycans in cancer	View

---

 

Expression of ACTB:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	ACTB	60	224594_x_at	0.0390	0.8753	Show
GSE20347	ACTB	60	200801_x_at	0.0584	0.4903	Show
GSE23400	ACTB	60	213867_x_at	-0.0521	0.1446	Show
GSE26886	ACTB	60	213867_x_at	-1.2040	0.0000	Show
GSE29001	ACTB	60	213867_x_at	-0.0926	0.5622	Show
GSE38129	ACTB	60	200801_x_at	-0.0240	0.7719	Show
GSE45670	ACTB	60	200801_x_at	0.0020	0.9867	Show
GSE53622	ACTB	60	41051	0.8449	0.0000	Show
GSE53624	ACTB	60	41051	0.4281	0.0000	Show
GSE63941	ACTB	60	200801_x_at	0.1479	0.6790	Show
GSE77861	ACTB	60	200801_x_at	0.0209	0.8429	Show
GSE97050	ACTB	60	A_23_P135769	-0.0478	0.8190	Show
SRP007169	ACTB	60	RNAseq	-1.1081	0.0090	Show
SRP008496	ACTB	60	RNAseq	-0.8458	0.0041	Show
SRP064894	ACTB	60	RNAseq	-0.1651	0.4373	Show
SRP133303	ACTB	60	RNAseq	0.2055	0.1574	Show
SRP159526	ACTB	60	RNAseq	-0.3149	0.3283	Show
SRP193095	ACTB	60	RNAseq	-0.0269	0.8535	Show
SRP219564	ACTB	60	RNAseq	-0.2356	0.5753	Show
TCGA	ACTB	60	RNAseq	0.0504	0.1411	Show

Upregulated datasets: 0; Downregulated datasets: 2.  Download Data

---

 

Survival by ACTB expression:

 

---

Copy number change of ACTB:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	ACTB	60	14	1	15	Show
GSE20123	ACTB	60	14	1	15	Show
GSE43470	ACTB	60	6	1	36	Show
GSE46452	ACTB	60	13	1	45	Show
GSE47630	ACTB	60	9	1	30	Show
GSE54993	ACTB	60	0	6	64	Show
GSE54994	ACTB	60	22	1	30	Show
GSE60625	ACTB	60	0	0	11	Show
GSE74703	ACTB	60	6	0	30	Show
GSE74704	ACTB	60	9	0	11	Show
TCGA	ACTB	60	56	5	35	Show

Total number of gains: 149; Total number of losses: 17; Total Number of normals: 322.  Download Data

---

 

Somatic mutations of ACTB:

 

---

 

Highly correlated genes for ACTB:

 

Showing top 20/162 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
ACTB	RBM5	0.712713	3	0	3
ACTB	JOSD2	0.711793	3	0	3
ACTB	CTF1	0.711371	3	0	3
ACTB	UBAP1	0.705289	3	0	3
ACTB	TPD52L2	0.703143	3	0	3
ACTB	APEH	0.700433	3	0	3
ACTB	CLIP3	0.699551	3	0	3
ACTB	AKT1S1	0.696395	3	0	3
ACTB	TMEM150A	0.689713	3	0	3
ACTB	NR4A2	0.687264	3	0	3
ACTB	PORCN	0.680006	3	0	3
ACTB	SNX17	0.678117	3	0	3
ACTB	POTEF	0.662626	4	0	4
ACTB	XRRA1	0.655513	3	0	3
ACTB	DNAH11	0.648715	3	0	3
ACTB	RND3	0.641479	4	0	3
ACTB	LATS2	0.640917	4	0	3
ACTB	RHOG	0.638403	4	0	3
ACTB	ANO8	0.636194	3	0	3
ACTB	DDR2	0.633962	4	0	3

For details and further investigation, click here