| Full name: epiregulin | Alias Symbol: ER | ||
| Type: protein-coding gene | Cytoband: 4q13.3 | ||
| Entrez ID: 2069 | HGNC ID: HGNC:3443 | Ensembl Gene: ENSG00000124882 | OMIM ID: 602061 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
EREG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04012 | ErbB signaling pathway |
Expression of EREG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EREG | 2069 | 205767_at | -1.5140 | 0.6282 | |
| GSE20347 | EREG | 2069 | 205767_at | -4.1967 | 0.0000 | |
| GSE23400 | EREG | 2069 | 205767_at | -1.9668 | 0.0000 | |
| GSE26886 | EREG | 2069 | 205767_at | -3.3956 | 0.0002 | |
| GSE29001 | EREG | 2069 | 205767_at | -2.6383 | 0.0106 | |
| GSE38129 | EREG | 2069 | 205767_at | -3.0779 | 0.0000 | |
| GSE45670 | EREG | 2069 | 205767_at | -0.1297 | 0.8750 | |
| GSE53622 | EREG | 2069 | 43498 | -1.5598 | 0.0000 | |
| GSE53624 | EREG | 2069 | 43498 | -1.9204 | 0.0000 | |
| GSE63941 | EREG | 2069 | 205767_at | -0.2254 | 0.9223 | |
| GSE77861 | EREG | 2069 | 205767_at | -2.5375 | 0.0114 | |
| GSE97050 | EREG | 2069 | A_23_P41344 | 0.5443 | 0.2620 | |
| SRP007169 | EREG | 2069 | RNAseq | -5.1189 | 0.0000 | |
| SRP008496 | EREG | 2069 | RNAseq | -2.6910 | 0.0176 | |
| SRP064894 | EREG | 2069 | RNAseq | -0.4482 | 0.4484 | |
| SRP133303 | EREG | 2069 | RNAseq | -0.5107 | 0.3069 | |
| SRP159526 | EREG | 2069 | RNAseq | -3.3863 | 0.0000 | |
| SRP193095 | EREG | 2069 | RNAseq | -0.7013 | 0.0865 | |
| SRP219564 | EREG | 2069 | RNAseq | -1.4223 | 0.1115 | |
| TCGA | EREG | 2069 | RNAseq | 0.6366 | 0.0846 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by EREG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EREG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EREG | 2069 | 2 | 9 | 19 | |
| GSE20123 | EREG | 2069 | 2 | 9 | 19 | |
| GSE43470 | EREG | 2069 | 0 | 13 | 30 | |
| GSE46452 | EREG | 2069 | 3 | 34 | 22 | |
| GSE47630 | EREG | 2069 | 1 | 19 | 20 | |
| GSE54993 | EREG | 2069 | 7 | 0 | 63 | |
| GSE54994 | EREG | 2069 | 1 | 9 | 43 | |
| GSE60625 | EREG | 2069 | 0 | 0 | 11 | |
| GSE74703 | EREG | 2069 | 0 | 11 | 25 | |
| GSE74704 | EREG | 2069 | 2 | 5 | 13 | |
| TCGA | EREG | 2069 | 19 | 28 | 49 |
Total number of gains: 37; Total number of losses: 137; Total Number of normals: 314.
Somatic mutations of EREG:
Generating mutation plots.
Highly correlated genes for EREG:
Showing top 20/615 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EREG | CDA | 0.766317 | 10 | 0 | 10 |
| EREG | CWH43 | 0.752551 | 10 | 0 | 10 |
| EREG | AREG | 0.718822 | 10 | 0 | 10 |
| EREG | GYS2 | 0.714467 | 9 | 0 | 8 |
| EREG | CES2 | 0.713906 | 7 | 0 | 7 |
| EREG | ECM1 | 0.713198 | 10 | 0 | 9 |
| EREG | ENDOU | 0.712305 | 10 | 0 | 9 |
| EREG | EPHA2 | 0.698398 | 10 | 0 | 10 |
| EREG | TGM1 | 0.695223 | 11 | 0 | 9 |
| EREG | CRISP3 | 0.69351 | 9 | 0 | 8 |
| EREG | DUSP5 | 0.689863 | 10 | 0 | 9 |
| EREG | PTK6 | 0.681625 | 12 | 0 | 10 |
| EREG | TMOD3 | 0.680342 | 11 | 0 | 9 |
| EREG | CRCT1 | 0.679688 | 12 | 0 | 11 |
| EREG | PHLDA1 | 0.679634 | 11 | 0 | 10 |
| EREG | EPB41L4A | 0.678517 | 7 | 0 | 6 |
| EREG | CLIC3 | 0.677399 | 9 | 0 | 7 |
| EREG | PPL | 0.676285 | 9 | 0 | 9 |
| EREG | SERPINB1 | 0.676095 | 11 | 0 | 9 |
| EREG | RANBP9 | 0.67437 | 9 | 0 | 8 |
For details and further investigation, click here
