| Full name: chitinase 3 like 1 | Alias Symbol: GP39|YKL40|YK-40 | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 1116 | HGNC ID: HGNC:1932 | Ensembl Gene: ENSG00000133048 | OMIM ID: 601525 |
| Drug and gene relationship at DGIdb | |||
Expression of CHI3L1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHI3L1 | 1116 | 209395_at | 1.4894 | 0.4284 | |
| GSE20347 | CHI3L1 | 1116 | 209396_s_at | 0.1270 | 0.8199 | |
| GSE23400 | CHI3L1 | 1116 | 216546_s_at | -0.0152 | 0.7568 | |
| GSE26886 | CHI3L1 | 1116 | 209395_at | -0.2205 | 0.8083 | |
| GSE29001 | CHI3L1 | 1116 | 209395_at | 0.1526 | 0.7991 | |
| GSE38129 | CHI3L1 | 1116 | 209395_at | 1.4825 | 0.0016 | |
| GSE45670 | CHI3L1 | 1116 | 209395_at | 1.0389 | 0.0467 | |
| GSE53622 | CHI3L1 | 1116 | 15478 | 2.1254 | 0.0000 | |
| GSE53624 | CHI3L1 | 1116 | 15478 | 1.5357 | 0.0000 | |
| GSE63941 | CHI3L1 | 1116 | 209395_at | -3.2011 | 0.0218 | |
| GSE77861 | CHI3L1 | 1116 | 209396_s_at | 0.0418 | 0.9278 | |
| GSE97050 | CHI3L1 | 1116 | A_23_P137665 | 2.7303 | 0.0684 | |
| SRP007169 | CHI3L1 | 1116 | RNAseq | 3.5680 | 0.0006 | |
| SRP008496 | CHI3L1 | 1116 | RNAseq | 1.9101 | 0.0470 | |
| SRP064894 | CHI3L1 | 1116 | RNAseq | 3.3760 | 0.0000 | |
| SRP133303 | CHI3L1 | 1116 | RNAseq | 2.4322 | 0.0000 | |
| SRP159526 | CHI3L1 | 1116 | RNAseq | 2.6573 | 0.0000 | |
| SRP193095 | CHI3L1 | 1116 | RNAseq | 1.7947 | 0.0000 | |
| SRP219564 | CHI3L1 | 1116 | RNAseq | 2.1683 | 0.0107 | |
| TCGA | CHI3L1 | 1116 | RNAseq | 1.1142 | 0.0000 |
Upregulated datasets: 12; Downregulated datasets: 1.
Survival by CHI3L1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHI3L1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHI3L1 | 1116 | 11 | 0 | 19 | |
| GSE20123 | CHI3L1 | 1116 | 11 | 0 | 19 | |
| GSE43470 | CHI3L1 | 1116 | 6 | 0 | 37 | |
| GSE46452 | CHI3L1 | 1116 | 3 | 1 | 55 | |
| GSE47630 | CHI3L1 | 1116 | 14 | 0 | 26 | |
| GSE54993 | CHI3L1 | 1116 | 0 | 6 | 64 | |
| GSE54994 | CHI3L1 | 1116 | 15 | 0 | 38 | |
| GSE60625 | CHI3L1 | 1116 | 0 | 0 | 11 | |
| GSE74703 | CHI3L1 | 1116 | 6 | 0 | 30 | |
| GSE74704 | CHI3L1 | 1116 | 5 | 0 | 15 | |
| TCGA | CHI3L1 | 1116 | 44 | 4 | 48 |
Total number of gains: 115; Total number of losses: 11; Total Number of normals: 362.
Somatic mutations of CHI3L1:
Generating mutation plots.
Highly correlated genes for CHI3L1:
Showing top 20/176 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHI3L1 | PLXNC1 | 0.690937 | 3 | 0 | 3 |
| CHI3L1 | GTSE1 | 0.674759 | 3 | 0 | 3 |
| CHI3L1 | A1BG | 0.673657 | 3 | 0 | 3 |
| CHI3L1 | PALM2 | 0.654454 | 3 | 0 | 3 |
| CHI3L1 | MGAT1 | 0.64862 | 3 | 0 | 3 |
| CHI3L1 | ADAM12 | 0.648477 | 5 | 0 | 4 |
| CHI3L1 | BGN | 0.642287 | 6 | 0 | 5 |
| CHI3L1 | SPHK1 | 0.641517 | 5 | 0 | 5 |
| CHI3L1 | PF4V1 | 0.638846 | 3 | 0 | 3 |
| CHI3L1 | SLC38A4 | 0.625069 | 3 | 0 | 3 |
| CHI3L1 | DCBLD1 | 0.623798 | 5 | 0 | 4 |
| CHI3L1 | PDIA5 | 0.6187 | 3 | 0 | 3 |
| CHI3L1 | RCN3 | 0.616163 | 7 | 0 | 6 |
| CHI3L1 | CDH11 | 0.615863 | 6 | 0 | 5 |
| CHI3L1 | COL5A1 | 0.615326 | 6 | 0 | 5 |
| CHI3L1 | CXorf65 | 0.612403 | 3 | 0 | 3 |
| CHI3L1 | ADAMTS2 | 0.610534 | 5 | 0 | 4 |
| CHI3L1 | CTSC | 0.607825 | 5 | 0 | 4 |
| CHI3L1 | SULF1 | 0.60556 | 5 | 0 | 4 |
| CHI3L1 | FANCB | 0.602288 | 3 | 0 | 3 |
For details and further investigation, click here
