| Full name: RUNX family transcription factor 1 | Alias Symbol: PEBP2A2|AMLCR1 | ||
| Type: protein-coding gene | Cytoband: 21q22.12 | ||
| Entrez ID: 861 | HGNC ID: HGNC:10471 | Ensembl Gene: ENSG00000159216 | OMIM ID: 151385 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
RUNX1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05220 | Chronic myeloid leukemia | |
| hsa05221 | Acute myeloid leukemia |
Expression of RUNX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | RUNX1 | 861 | 35821 | 1.6531 | 0.0000 | |
| GSE53624 | RUNX1 | 861 | 35821 | 0.4061 | 0.0000 | |
| GSE97050 | RUNX1 | 861 | A_33_P3211809 | 1.7360 | 0.0976 | |
| SRP007169 | RUNX1 | 861 | RNAseq | 1.9310 | 0.0000 | |
| SRP008496 | RUNX1 | 861 | RNAseq | 2.4013 | 0.0000 | |
| SRP064894 | RUNX1 | 861 | RNAseq | 1.7975 | 0.0000 | |
| SRP133303 | RUNX1 | 861 | RNAseq | 1.4227 | 0.0000 | |
| SRP159526 | RUNX1 | 861 | RNAseq | 1.4515 | 0.0000 | |
| SRP193095 | RUNX1 | 861 | RNAseq | 1.4013 | 0.0000 | |
| SRP219564 | RUNX1 | 861 | RNAseq | 1.8356 | 0.0000 | |
| TCGA | RUNX1 | 861 | RNAseq | 0.2813 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by RUNX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RUNX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RUNX1 | 861 | 2 | 8 | 20 | |
| GSE20123 | RUNX1 | 861 | 2 | 8 | 20 | |
| GSE43470 | RUNX1 | 861 | 1 | 11 | 31 | |
| GSE46452 | RUNX1 | 861 | 1 | 21 | 37 | |
| GSE47630 | RUNX1 | 861 | 6 | 17 | 17 | |
| GSE54993 | RUNX1 | 861 | 9 | 1 | 60 | |
| GSE54994 | RUNX1 | 861 | 1 | 9 | 43 | |
| GSE60625 | RUNX1 | 861 | 0 | 0 | 11 | |
| GSE74703 | RUNX1 | 861 | 1 | 8 | 27 | |
| GSE74704 | RUNX1 | 861 | 1 | 5 | 14 | |
| TCGA | RUNX1 | 861 | 10 | 39 | 47 |
Total number of gains: 34; Total number of losses: 127; Total Number of normals: 327.
Somatic mutations of RUNX1:
Generating mutation plots.
Highly correlated genes for RUNX1:
Showing top 20/36 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RUNX1 | LAMC2 | 0.760192 | 3 | 0 | 3 |
| RUNX1 | ITGA6 | 0.751139 | 3 | 0 | 3 |
| RUNX1 | ADAM12 | 0.719534 | 3 | 0 | 3 |
| RUNX1 | CTHRC1 | 0.714366 | 4 | 0 | 4 |
| RUNX1 | ADAMTS12 | 0.705689 | 3 | 0 | 3 |
| RUNX1 | POSTN | 0.67658 | 4 | 0 | 3 |
| RUNX1 | COL1A1 | 0.670836 | 4 | 0 | 3 |
| RUNX1 | PLAU | 0.670754 | 3 | 0 | 3 |
| RUNX1 | MMP11 | 0.668477 | 4 | 0 | 3 |
| RUNX1 | COL10A1 | 0.664084 | 4 | 0 | 4 |
| RUNX1 | COL5A2 | 0.655219 | 4 | 0 | 4 |
| RUNX1 | TGFBI | 0.654345 | 3 | 0 | 3 |
| RUNX1 | MFAP2 | 0.645786 | 4 | 0 | 3 |
| RUNX1 | SULF1 | 0.645723 | 4 | 0 | 4 |
| RUNX1 | COL3A1 | 0.641398 | 4 | 0 | 3 |
| RUNX1 | RCN3 | 0.637226 | 3 | 0 | 3 |
| RUNX1 | VCAN | 0.637045 | 4 | 0 | 4 |
| RUNX1 | CDH11 | 0.637017 | 4 | 0 | 3 |
| RUNX1 | LOXL2 | 0.621735 | 3 | 0 | 3 |
| RUNX1 | ZNF469 | 0.619262 | 4 | 0 | 3 |
For details and further investigation, click here
