| Full name: SPOC domain containing 1 | Alias Symbol: FLJ25348|PPP1R146 | ||
| Type: protein-coding gene | Cytoband: 1p35.2 | ||
| Entrez ID: 90853 | HGNC ID: HGNC:26338 | Ensembl Gene: ENSG00000134668 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of SPOCD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPOCD1 | 90853 | 235417_at | 0.3436 | 0.2130 | |
| GSE26886 | SPOCD1 | 90853 | 235417_at | 0.4695 | 0.0028 | |
| GSE45670 | SPOCD1 | 90853 | 235417_at | 0.3048 | 0.1336 | |
| GSE53622 | SPOCD1 | 90853 | 73752 | 1.5367 | 0.0000 | |
| GSE53624 | SPOCD1 | 90853 | 73752 | 2.4277 | 0.0000 | |
| GSE63941 | SPOCD1 | 90853 | 235417_at | -1.5258 | 0.0478 | |
| GSE77861 | SPOCD1 | 90853 | 235417_at | 0.0857 | 0.4881 | |
| SRP064894 | SPOCD1 | 90853 | RNAseq | 3.5827 | 0.0000 | |
| SRP133303 | SPOCD1 | 90853 | RNAseq | 3.6561 | 0.0000 | |
| SRP159526 | SPOCD1 | 90853 | RNAseq | 2.7743 | 0.0019 | |
| TCGA | SPOCD1 | 90853 | RNAseq | 1.1272 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 1.
Survival by SPOCD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPOCD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPOCD1 | 90853 | 1 | 5 | 24 | |
| GSE20123 | SPOCD1 | 90853 | 1 | 4 | 25 | |
| GSE43470 | SPOCD1 | 90853 | 6 | 4 | 33 | |
| GSE46452 | SPOCD1 | 90853 | 5 | 1 | 53 | |
| GSE47630 | SPOCD1 | 90853 | 8 | 3 | 29 | |
| GSE54993 | SPOCD1 | 90853 | 1 | 1 | 68 | |
| GSE54994 | SPOCD1 | 90853 | 11 | 2 | 40 | |
| GSE60625 | SPOCD1 | 90853 | 0 | 0 | 11 | |
| GSE74703 | SPOCD1 | 90853 | 4 | 3 | 29 | |
| GSE74704 | SPOCD1 | 90853 | 0 | 0 | 20 | |
| TCGA | SPOCD1 | 90853 | 13 | 19 | 64 |
Total number of gains: 50; Total number of losses: 42; Total Number of normals: 396.
Somatic mutations of SPOCD1:
Generating mutation plots.
Highly correlated genes for SPOCD1:
Showing top 20/607 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPOCD1 | RUNX1-IT1 | 0.71782 | 3 | 0 | 3 |
| SPOCD1 | ADAMTS6 | 0.705558 | 5 | 0 | 4 |
| SPOCD1 | LOXL2 | 0.704695 | 6 | 0 | 6 |
| SPOCD1 | SLC4A1AP | 0.701826 | 3 | 0 | 3 |
| SPOCD1 | WDR54 | 0.70056 | 5 | 0 | 5 |
| SPOCD1 | HOMER3 | 0.69987 | 6 | 0 | 6 |
| SPOCD1 | ZNF469 | 0.694883 | 7 | 0 | 6 |
| SPOCD1 | SERPINE1 | 0.688933 | 7 | 0 | 6 |
| SPOCD1 | OSMR | 0.68562 | 5 | 0 | 5 |
| SPOCD1 | USB1 | 0.684966 | 7 | 0 | 7 |
| SPOCD1 | PTHLH | 0.682412 | 5 | 0 | 4 |
| SPOCD1 | CLEC11A | 0.682386 | 4 | 0 | 4 |
| SPOCD1 | COL5A3 | 0.680895 | 7 | 0 | 7 |
| SPOCD1 | INHBA | 0.680117 | 6 | 0 | 6 |
| SPOCD1 | SH2D5 | 0.679689 | 7 | 0 | 6 |
| SPOCD1 | LAMC2 | 0.677003 | 6 | 0 | 6 |
| SPOCD1 | ADAMTS12 | 0.671264 | 6 | 0 | 5 |
| SPOCD1 | TNFRSF12A | 0.67126 | 7 | 0 | 6 |
| SPOCD1 | HYAL2 | 0.668378 | 3 | 0 | 3 |
| SPOCD1 | MMP1 | 0.668088 | 7 | 0 | 6 |
For details and further investigation, click here
