Full name: membrane metalloendopeptidase	Alias Symbol: CALLA|CD10|NEP
Type: protein-coding gene	Cytoband: 3q25.2
Entrez ID: 4311	HGNC ID: HGNC:7154	Ensembl Gene: ENSG00000196549	OMIM ID: 120520
Drug and gene relationship at DGIdb

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Expression of MME:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	MME	4311	203435_s_at	0.9976	0.0900	Show
GSE20347	MME	4311	203435_s_at	0.4177	0.0007	Show
GSE23400	MME	4311	203435_s_at	0.0692	0.4603	Show
GSE26886	MME	4311	203435_s_at	0.2588	0.2440	Show
GSE29001	MME	4311	203435_s_at	0.2367	0.4270	Show
GSE38129	MME	4311	203435_s_at	0.2830	0.2647	Show
GSE45670	MME	4311	203435_s_at	0.4940	0.1006	Show
GSE53622	MME	4311	117619	1.6392	0.0000	Show
GSE53624	MME	4311	64763	1.6301	0.0000	Show
GSE63941	MME	4311	203435_s_at	-3.0187	0.0018	Show
GSE77861	MME	4311	203435_s_at	0.0445	0.7730	Show
GSE97050	MME	4311	A_33_P3370094	-0.0256	0.9648	Show
SRP007169	MME	4311	RNAseq	3.2654	0.0000	Show
SRP008496	MME	4311	RNAseq	3.7891	0.0000	Show
SRP064894	MME	4311	RNAseq	2.2959	0.0000	Show
SRP133303	MME	4311	RNAseq	4.2219	0.0000	Show
SRP159526	MME	4311	RNAseq	1.6946	0.0486	Show
SRP193095	MME	4311	RNAseq	1.6033	0.0000	Show
SRP219564	MME	4311	RNAseq	1.5631	0.0277	Show
TCGA	MME	4311	RNAseq	0.6336	0.0060	Show

Upregulated datasets: 9; Downregulated datasets: 1.  Download Data

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Survival by MME expression:

 

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Copy number change of MME:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	MME	4311	21	1	8	Show
GSE20123	MME	4311	21	1	8	Show
GSE43470	MME	4311	23	0	20	Show
GSE46452	MME	4311	18	2	39	Show
GSE47630	MME	4311	19	3	18	Show
GSE54993	MME	4311	1	11	58	Show
GSE54994	MME	4311	38	1	14	Show
GSE60625	MME	4311	0	6	5	Show
GSE74703	MME	4311	20	0	16	Show
GSE74704	MME	4311	14	0	6	Show
TCGA	MME	4311	73	1	22	Show

Total number of gains: 248; Total number of losses: 26; Total Number of normals: 214.  Download Data

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Somatic mutations of MME:

 

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Highly correlated genes for MME:

 

Showing top 20/417 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
MME	TBX5	0.712379	3	0	3
MME	KIR3DL3	0.711246	3	0	3
MME	MMP3	0.708621	6	0	6
MME	PAG1	0.683503	4	0	4
MME	C1QTNF6	0.675602	5	0	4
MME	SH3PXD2B	0.674123	5	0	5
MME	ADAMTS12	0.665959	7	0	5
MME	ZC3H7B	0.661576	3	0	3
MME	GLIS3	0.656888	6	0	5
MME	MMP1	0.6565	7	0	5
MME	TMEM174	0.65254	4	0	4
MME	P4HA3	0.644995	7	0	6
MME	ADAM12	0.642967	5	0	4
MME	LINC01094	0.642496	3	0	3
MME	HAGHL	0.637758	4	0	4
MME	A1BG	0.636211	4	0	3
MME	PLOD1	0.63491	6	0	5
MME	TTYH3	0.633138	6	0	5
MME	CHST11	0.630957	7	0	6
MME	GPRIN1	0.6297	4	0	3

For details and further investigation, click here