Full name: serine dehydratase	Alias Symbol: SDH
Type: protein-coding gene	Cytoband: 12q24.13
Entrez ID: 10993	HGNC ID: HGNC:10691	Ensembl Gene: ENSG00000135094	OMIM ID: 182128
Drug and gene relationship at DGIdb

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Expression of SDS:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	SDS	10993	205695_at	0.7010	0.1259	Show
GSE20347	SDS	10993	205695_at	0.2064	0.0051	Show
GSE23400	SDS	10993	205695_at	0.1903	0.0037	Show
GSE26886	SDS	10993	205695_at	0.3614	0.0316	Show
GSE29001	SDS	10993	205695_at	0.5627	0.0502	Show
GSE38129	SDS	10993	205695_at	0.3997	0.0000	Show
GSE45670	SDS	10993	205695_at	0.3285	0.0067	Show
GSE53622	SDS	10993	67794	1.9922	0.0000	Show
GSE53624	SDS	10993	67794	2.2040	0.0000	Show
GSE63941	SDS	10993	205695_at	-0.0719	0.7073	Show
GSE77861	SDS	10993	205695_at	0.0499	0.6904	Show
GSE97050	SDS	10993	A_23_P2645	0.7466	0.1337	Show
SRP007169	SDS	10993	RNAseq	4.7161	0.0001	Show
SRP008496	SDS	10993	RNAseq	4.8129	0.0000	Show
SRP064894	SDS	10993	RNAseq	2.5819	0.0000	Show
SRP133303	SDS	10993	RNAseq	3.1359	0.0000	Show
SRP159526	SDS	10993	RNAseq	2.9895	0.0001	Show
SRP219564	SDS	10993	RNAseq	3.0761	0.0004	Show
TCGA	SDS	10993	RNAseq	1.6428	0.0000	Show

Upregulated datasets: 9; Downregulated datasets: 0.  Download Data

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Survival by SDS expression:

 

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Copy number change of SDS:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	SDS	10993	4	3	23	Show
GSE20123	SDS	10993	4	3	23	Show
GSE43470	SDS	10993	2	0	41	Show
GSE46452	SDS	10993	9	1	49	Show
GSE47630	SDS	10993	9	3	28	Show
GSE54993	SDS	10993	0	5	65	Show
GSE54994	SDS	10993	4	2	47	Show
GSE60625	SDS	10993	0	0	11	Show
GSE74703	SDS	10993	2	0	34	Show
GSE74704	SDS	10993	2	2	16	Show
TCGA	SDS	10993	22	11	63	Show

Total number of gains: 58; Total number of losses: 30; Total Number of normals: 400.  Download Data

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Somatic mutations of SDS:

 

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Highly correlated genes for SDS:

 

Showing top 20/562 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
SDS	SUCNR1	0.688161	3	0	3
SDS	LRR1	0.685671	4	0	4
SDS	CD300LF	0.679039	6	0	5
SDS	CD300E	0.675487	3	0	3
SDS	HOXC9	0.673174	3	0	3
SDS	ULBP1	0.671686	3	0	3
SDS	SDK1	0.669479	4	0	4
SDS	XRN2	0.667301	4	0	4
SDS	PDIA4	0.664421	7	0	7
SDS	ST20	0.664179	3	0	3
SDS	CMTM3	0.663483	4	0	3
SDS	RIMS4	0.657831	3	0	3
SDS	ADAMTS12	0.656801	6	0	4
SDS	LRWD1	0.653476	3	0	3
SDS	RENBP	0.652934	6	0	5
SDS	CDCA5	0.652313	6	0	6
SDS	SNAI1	0.650896	5	0	5
SDS	ADAM12	0.647722	5	0	4
SDS	RCN3	0.647499	7	0	6
SDS	XPR1	0.644913	5	0	4

For details and further investigation, click here