Full name: serine dehydratase | Alias Symbol: SDH | ||
Type: protein-coding gene | Cytoband: 12q24.13 | ||
Entrez ID: 10993 | HGNC ID: HGNC:10691 | Ensembl Gene: ENSG00000135094 | OMIM ID: 182128 |
Drug and gene relationship at DGIdb |
Expression of SDS:
Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
---|---|---|---|---|---|---|
GSE17351 | SDS | 10993 | 205695_at | 0.7010 | 0.1259 | |
GSE20347 | SDS | 10993 | 205695_at | 0.2064 | 0.0051 | |
GSE23400 | SDS | 10993 | 205695_at | 0.1903 | 0.0037 | |
GSE26886 | SDS | 10993 | 205695_at | 0.3614 | 0.0316 | |
GSE29001 | SDS | 10993 | 205695_at | 0.5627 | 0.0502 | |
GSE38129 | SDS | 10993 | 205695_at | 0.3997 | 0.0000 | |
GSE45670 | SDS | 10993 | 205695_at | 0.3285 | 0.0067 | |
GSE53622 | SDS | 10993 | 67794 | 1.9922 | 0.0000 | |
GSE53624 | SDS | 10993 | 67794 | 2.2040 | 0.0000 | |
GSE63941 | SDS | 10993 | 205695_at | -0.0719 | 0.7073 | |
GSE77861 | SDS | 10993 | 205695_at | 0.0499 | 0.6904 | |
GSE97050 | SDS | 10993 | A_23_P2645 | 0.7466 | 0.1337 | |
SRP007169 | SDS | 10993 | RNAseq | 4.7161 | 0.0001 | |
SRP008496 | SDS | 10993 | RNAseq | 4.8129 | 0.0000 | |
SRP064894 | SDS | 10993 | RNAseq | 2.5819 | 0.0000 | |
SRP133303 | SDS | 10993 | RNAseq | 3.1359 | 0.0000 | |
SRP159526 | SDS | 10993 | RNAseq | 2.9895 | 0.0001 | |
SRP219564 | SDS | 10993 | RNAseq | 3.0761 | 0.0004 | |
TCGA | SDS | 10993 | RNAseq | 1.6428 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by SDS expression:
Note: Click image to view full size file.
Copy number change of SDS:
Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
---|---|---|---|---|---|---|
GSE15526 | SDS | 10993 | 4 | 3 | 23 | |
GSE20123 | SDS | 10993 | 4 | 3 | 23 | |
GSE43470 | SDS | 10993 | 2 | 0 | 41 | |
GSE46452 | SDS | 10993 | 9 | 1 | 49 | |
GSE47630 | SDS | 10993 | 9 | 3 | 28 | |
GSE54993 | SDS | 10993 | 0 | 5 | 65 | |
GSE54994 | SDS | 10993 | 4 | 2 | 47 | |
GSE60625 | SDS | 10993 | 0 | 0 | 11 | |
GSE74703 | SDS | 10993 | 2 | 0 | 34 | |
GSE74704 | SDS | 10993 | 2 | 2 | 16 | |
TCGA | SDS | 10993 | 22 | 11 | 63 |
Total number of gains: 58; Total number of losses: 30; Total Number of normals: 400.
Somatic mutations of SDS:
Generating mutation plots.
Highly correlated genes for SDS:
Showing top 20/562 corelated genes with mean PCC>0.5.
Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
---|---|---|---|---|---|
SDS | SUCNR1 | 0.688161 | 3 | 0 | 3 |
SDS | LRR1 | 0.685671 | 4 | 0 | 4 |
SDS | CD300LF | 0.679039 | 6 | 0 | 5 |
SDS | CD300E | 0.675487 | 3 | 0 | 3 |
SDS | HOXC9 | 0.673174 | 3 | 0 | 3 |
SDS | ULBP1 | 0.671686 | 3 | 0 | 3 |
SDS | SDK1 | 0.669479 | 4 | 0 | 4 |
SDS | XRN2 | 0.667301 | 4 | 0 | 4 |
SDS | PDIA4 | 0.664421 | 7 | 0 | 7 |
SDS | ST20 | 0.664179 | 3 | 0 | 3 |
SDS | CMTM3 | 0.663483 | 4 | 0 | 3 |
SDS | RIMS4 | 0.657831 | 3 | 0 | 3 |
SDS | ADAMTS12 | 0.656801 | 6 | 0 | 4 |
SDS | LRWD1 | 0.653476 | 3 | 0 | 3 |
SDS | RENBP | 0.652934 | 6 | 0 | 5 |
SDS | CDCA5 | 0.652313 | 6 | 0 | 6 |
SDS | SNAI1 | 0.650896 | 5 | 0 | 5 |
SDS | ADAM12 | 0.647722 | 5 | 0 | 4 |
SDS | RCN3 | 0.647499 | 7 | 0 | 6 |
SDS | XPR1 | 0.644913 | 5 | 0 | 4 |
For details and further investigation, click here