SDS

 

Full name: serine dehydratase Alias Symbol: SDH
Type: protein-coding gene Cytoband: 12q24.13
Entrez ID: 10993 HGNC ID: HGNC:10691 Ensembl Gene: ENSG00000135094 OMIM ID: 182128
Drug and gene relationship at DGIdb

 

Expression of SDS:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SDS 10993 205695_at 0.7010 0.1259
GSE20347 SDS 10993 205695_at 0.2064 0.0051
GSE23400 SDS 10993 205695_at 0.1903 0.0037
GSE26886 SDS 10993 205695_at 0.3614 0.0316
GSE29001 SDS 10993 205695_at 0.5627 0.0502
GSE38129 SDS 10993 205695_at 0.3997 0.0000
GSE45670 SDS 10993 205695_at 0.3285 0.0067
GSE53622 SDS 10993 67794 1.9922 0.0000
GSE53624 SDS 10993 67794 2.2040 0.0000
GSE63941 SDS 10993 205695_at -0.0719 0.7073
GSE77861 SDS 10993 205695_at 0.0499 0.6904
GSE97050 SDS 10993 A_23_P2645 0.7466 0.1337
SRP007169 SDS 10993 RNAseq 4.7161 0.0001
SRP008496 SDS 10993 RNAseq 4.8129 0.0000
SRP064894 SDS 10993 RNAseq 2.5819 0.0000
SRP133303 SDS 10993 RNAseq 3.1359 0.0000
SRP159526 SDS 10993 RNAseq 2.9895 0.0001
SRP219564 SDS 10993 RNAseq 3.0761 0.0004
TCGA SDS 10993 RNAseq 1.6428 0.0000

Upregulated datasets: 9; Downregulated datasets: 0.  


 

Survival by SDS expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of SDS:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SDS 10993 4 3 23
GSE20123 SDS 10993 4 3 23
GSE43470 SDS 10993 2 0 41
GSE46452 SDS 10993 9 1 49
GSE47630 SDS 10993 9 3 28
GSE54993 SDS 10993 0 5 65
GSE54994 SDS 10993 4 2 47
GSE60625 SDS 10993 0 0 11
GSE74703 SDS 10993 2 0 34
GSE74704 SDS 10993 2 2 16
TCGA SDS 10993 22 11 63

Total number of gains: 58; Total number of losses: 30; Total Number of normals: 400.  


 

Somatic mutations of SDS:

 

Generating mutation plots.

 

Highly correlated genes for SDS:

 

Showing top 20/562 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SDSSUCNR10.688161303
SDSLRR10.685671404
SDSCD300LF0.679039605
SDSCD300E0.675487303
SDSHOXC90.673174303
SDSULBP10.671686303
SDSSDK10.669479404
SDSXRN20.667301404
SDSPDIA40.664421707
SDSST200.664179303
SDSCMTM30.663483403
SDSRIMS40.657831303
SDSADAMTS120.656801604
SDSLRWD10.653476303
SDSRENBP0.652934605
SDSCDCA50.652313606
SDSSNAI10.650896505
SDSADAM120.647722504
SDSRCN30.647499706
SDSXPR10.644913504

For details and further investigation, click here