| Full name: ZW10 interacting kinetochore protein | Alias Symbol: KNTC2AP|SIP30|Zwint1 | ||
| Type: protein-coding gene | Cytoband: 10q21.1 | ||
| Entrez ID: 11130 | HGNC ID: HGNC:13195 | Ensembl Gene: ENSG00000122952 | OMIM ID: 609177 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ZWINT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZWINT | 11130 | 204026_s_at | 1.0232 | 0.0900 | |
| GSE20347 | ZWINT | 11130 | 204026_s_at | 1.1067 | 0.0000 | |
| GSE23400 | ZWINT | 11130 | 204026_s_at | 1.2691 | 0.0000 | |
| GSE26886 | ZWINT | 11130 | 204026_s_at | -0.0327 | 0.9078 | |
| GSE29001 | ZWINT | 11130 | 204026_s_at | 0.9858 | 0.0012 | |
| GSE38129 | ZWINT | 11130 | 204026_s_at | 1.5718 | 0.0000 | |
| GSE45670 | ZWINT | 11130 | 204026_s_at | 1.0130 | 0.0000 | |
| GSE53622 | ZWINT | 11130 | 139638 | 0.6242 | 0.0000 | |
| GSE53624 | ZWINT | 11130 | 139638 | 0.9561 | 0.0000 | |
| GSE63941 | ZWINT | 11130 | 204026_s_at | 2.7689 | 0.0003 | |
| GSE77861 | ZWINT | 11130 | 204026_s_at | 0.4388 | 0.2952 | |
| GSE97050 | ZWINT | 11130 | A_33_P3212994 | 0.5913 | 0.1657 | |
| SRP007169 | ZWINT | 11130 | RNAseq | 2.0172 | 0.0003 | |
| SRP008496 | ZWINT | 11130 | RNAseq | 1.6004 | 0.0000 | |
| SRP064894 | ZWINT | 11130 | RNAseq | 1.0872 | 0.0001 | |
| SRP133303 | ZWINT | 11130 | RNAseq | 1.2970 | 0.0000 | |
| SRP159526 | ZWINT | 11130 | RNAseq | 0.8460 | 0.0448 | |
| SRP193095 | ZWINT | 11130 | RNAseq | 0.4893 | 0.0019 | |
| SRP219564 | ZWINT | 11130 | RNAseq | 1.1087 | 0.0825 | |
| TCGA | ZWINT | 11130 | RNAseq | 0.6903 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by ZWINT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZWINT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZWINT | 11130 | 3 | 8 | 19 | |
| GSE20123 | ZWINT | 11130 | 3 | 8 | 19 | |
| GSE43470 | ZWINT | 11130 | 2 | 5 | 36 | |
| GSE46452 | ZWINT | 11130 | 0 | 13 | 46 | |
| GSE47630 | ZWINT | 11130 | 4 | 12 | 24 | |
| GSE54993 | ZWINT | 11130 | 9 | 0 | 61 | |
| GSE54994 | ZWINT | 11130 | 2 | 11 | 40 | |
| GSE60625 | ZWINT | 11130 | 0 | 0 | 11 | |
| GSE74703 | ZWINT | 11130 | 2 | 3 | 31 | |
| GSE74704 | ZWINT | 11130 | 1 | 5 | 14 | |
| TCGA | ZWINT | 11130 | 11 | 22 | 63 |
Total number of gains: 37; Total number of losses: 87; Total Number of normals: 364.
Somatic mutations of ZWINT:
Generating mutation plots.
Highly correlated genes for ZWINT:
Showing top 20/667 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZWINT | CENPF | 0.823231 | 10 | 0 | 10 |
| ZWINT | CDK1 | 0.809755 | 12 | 0 | 11 |
| ZWINT | BUB1B | 0.807331 | 11 | 0 | 10 |
| ZWINT | CDC20 | 0.79649 | 12 | 0 | 12 |
| ZWINT | NEK2 | 0.791925 | 12 | 0 | 11 |
| ZWINT | CEP55 | 0.79155 | 12 | 0 | 11 |
| ZWINT | KIF11 | 0.791187 | 12 | 0 | 12 |
| ZWINT | CENPW | 0.786034 | 6 | 0 | 6 |
| ZWINT | CDCA8 | 0.783587 | 12 | 0 | 12 |
| ZWINT | KIF2C | 0.777859 | 12 | 0 | 11 |
| ZWINT | KNSTRN | 0.775254 | 6 | 0 | 6 |
| ZWINT | MELK | 0.773725 | 12 | 0 | 11 |
| ZWINT | CKS1B | 0.77091 | 11 | 0 | 11 |
| ZWINT | FANCG | 0.769387 | 10 | 0 | 10 |
| ZWINT | UBE2T | 0.767042 | 7 | 0 | 6 |
| ZWINT | MCM2 | 0.76636 | 13 | 0 | 13 |
| ZWINT | FEN1 | 0.766132 | 10 | 0 | 10 |
| ZWINT | PRC1 | 0.765135 | 12 | 0 | 11 |
| ZWINT | CCNA2 | 0.764736 | 12 | 0 | 11 |
| ZWINT | ADAM21 | 0.764584 | 3 | 0 | 3 |
For details and further investigation, click here
